THE EFFECT OF TAURINE ON REPRODUCTIVE EFFICIENCY IN MALE RATS FED HIGH CHOLESTEROL DIET

2013 ◽  
Vol 12 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Nameer A.Kareem Alzubaidi Mohammed Ali Al Diwan
Keyword(s):  
Male Rats ◽  
Reproductive Efficiency ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL

Biomedika ◽  
2013 ◽  
Vol 5 (2) ◽  
Author(s):  
. Muhtadi ◽  
. Haryoto ◽  
Tanti Azizah Sujono ◽  
Peni Indaryudha ◽  
Andi Suhendi
Keyword(s):  
Ethanolic Extract ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Hypolipidemic Effect ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Control Group Design ◽  
Group I ◽  
Nephelium Lappaceum

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet

scholarly journals Effects of anthocyanin-rich purple potato flakes on antioxidant status in F344 rats fed a cholesterol-rich diet

2007 ◽  
Vol 98 (5) ◽  
pp. 914-921 ◽  
Author(s):  
Kyu-Ho Han ◽  
Asami Matsumoto ◽  
Ken-ichiro Shimada ◽  
Mitsuo Sekikawa ◽  
Michihiro Fukushima
Keyword(s):  
Solanum Tuberosum ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Antioxidant Enzyme Activities ◽  
Thiobarbituric Acid Reactive Substance ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Potato Flake ◽  
Hepatic Glutathione

We examined the antioxidant effects of polyphenol/anthocyanin-rich potato (Solanum tuberosum cv. Shadow-Queen) flakes in male rats fed a high-cholesterol diet. The rats were served either a high-cholesterol (0·5 % cholesterol plus 0·125 % sodium cholate) diet, or a high-cholesterol diet containing a mixture of 243 g α-maize starch/kg supplemented with one of the following (per kg diet): 300 g medium purple potato (Shadow-Queen), 300 g white potato (Solanum tuberosum cv. Toyoshiro) or 300 g dark purple sweet potato (Ipomoea batatas cv. Ayamurasaki) flakes for 28 d. We analysed thiobarbituric acid reactive substance (TBARS) levels in the serum and liver, and antioxidant enzyme activities in the liver. At this dosage, TBARS levels in the serum and liver of the Shadow-Queen and Ayamurasaki groups were significantly lower than those in the control and Toyoshiro groups. The serum urate levels in all the flake groups were significantly lower than that in the control group. The hepatic glutathione levels in the Shadow-Queen and Ayamurasaki groups were significantly higher than in the control and Toyoshiro groups. The activities of hepatic glutathione reductase and glutathione S-transferase in the Shadow-Queen and Ayamurasaki groups were significantly greater than those in the control group. These results show that modulation of antioxidant enzymes and oxidative status in the serum and liver by the purple potato flake diet (Shadow-Queen) containing polyphenols/anthocyanins may play an important role in the protection against adverse effects related to oxidative damage in rats fed a high-cholesterol diet.

scholarly journals Decreasing serum homocysteine and hypocholesterolemic effects of bovine lactoferrin in male rat fed with high-cholesterol diet

2018 ◽  
Vol 10 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Samira Nozari ◽  
Nazila Fathi Maroufi ◽  
Mohammad Nouri ◽  
Mirhamid Paytakhti Oskouei ◽  
Javad Shiralizade ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Male Rat ◽  
High Cholesterol Diet ◽  
Bovine Lactoferrin ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Serum Homocysteine

Introduction: Lipid metabolism disorder or hyperlipidemia is known as a risk factor for cardiovascular disease, the increase in serum homocysteine and leptin are associated with atherosclerotic disease. The purpose of the present study was to examine the effects of bovine lactoferrin (bLF) on serum homocysteine (Hcy), apolipoproteinA-I (ApoA-I) and B (ApoB), leptin and lipid profile changes in high-cholesterol-diet (HCD) fed rats. Methods: The Healthy Adult Sprague-Dawley (SD) male rats were randomly assigned into three experimental groups. Each group consisted of eleven male rats including control group, HCD rats and hypercholesterolemic rats, which were treated with bLF (HCD+bLF). bLF was given by gavage (200 mg/kg/d). After 4 weeks of feeding and overnight fasting, total blood samples were collected. Results: The results showed the elevated level of Hcy, leptin, total cholesterol, low density lipoprotein cholesterol (LDL-C), ApoB and decrease in ApoA-I in non-treated HCD group compared to the control rats. Administration of bLF significantly ameliorated the Hcy and leptin levels with decrease in LDL-C and total cholesterol in rats fed with a high-cholesterol diet. bLF also tended to increase low serum concentration of ApoA-I and high density lipoprotein cholesterol (HDL-C) in HCD rats. Meanwhile, upon bLF-treated rats, there was a significant decrease in ApoB in HCD group. Conclusion: The findings indicated that bLF can improve the alteration of serum Hcy, leptin, apolipproteins and lipid changes in male rats fed with high-cholesterol diet. So, bLF can counteract with HCD elicited hyper-homocysteinemia and hyper-leptinemia, suggesting it to have the useful therapeutic potential in patients with atherosclerosis and lipid disorder.

scholarly journals Potential of Lactobacillus casei Shirota Strain Probiotic Toward Total Cholesterol Levels and Sod Activity in Rat with High Cholesterol Diet

Molekul ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. 153
Author(s):  
Kiswanti Surya Utami ◽  
Aulanni'am Aulanni’am ◽  
Chanif Mahdi
Keyword(s):  
Total Cholesterol ◽  
Lactobacillus Casei ◽  
Positive Control ◽  
Male Rats ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Sod Activity ◽  
Lactobacillus Casei Shirota

Probiotic of Lactobacillus casei Shirota strain is lactic acid bacteria that have benefits to enhance immunity system, as an antioxidant and has the ability to decrease the cholesterol level. The aim of this study was to determine the potential of Lactobacillus casei Shirota strain probiotic toward total cholesterol decreasing and SOD activity increasing in rats’ aorta with a high-cholesterol diet. This study used 25 male rats of Rattus novergicus Wistar strain that will be divided into 5 groups. The 1st group as the negative control, and the 2nd group as positive control. The positive control group was induced by high-cholesterol diet contained quail egg yolk, pure cholesterol, cholic acid and waste oil that were given for 3 weeks. The 3rd, 4th and 5th group were treated by probiotic Lactobacillus casei Shirota strain with variation dose of 3.6 x 107, 7.3 x 107 and 10.9 x 107 cells/kg bodyweight/day. The results showed that probiotic of Lactobacillus casei Shirota strain therapy dose of 10.9 x 107 cells/kg bodyweight/day can decrease the total blood cholesterol of rats’ serum that were given with high-cholesterol diet of about 32.0%. In addition, the probiotic of Lactobacillus casei Shirota strain therapy also increase the activity of SOD about 50.70%.

scholarly journals Antioxidant and Hypolipidemic Effects of Ipomoea batatas L and Pandanus conoideus Lam Combination on Rats Fed with High Cholesterol Diet

2021 ◽  
Vol 9 (A) ◽  
pp. 473-476
Author(s):  
A. A. Ngurah Subawa ◽  
I Wayan Putu Sutirta Yasa ◽  
I Made Jawi ◽  
Agung Nova Mahendra
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Ipomoea Batatas ◽  
Single Agent ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

BACKGROUND: Chronic hypercholesterolemia is an important predisposing factor of cardiovascular diseases. The underlying process is commonly associated with oxidative stress. AIM: This study aimed to evaluate the effects of Ipomoea batatas (IB) L tablet and Pandanus conoideus (PC) Lam extract against oxidative stress and lipid profile in rats. METHODS: This study used a pre- and post-test control group design. Wistar male rats were randomized into four groups consisting of seven rats each. The groups were control group, PC Lam extract 0.4 cc/rat/day (PC group), IB L tablet 200 mg/rat/day (IB group), and PC 0.2 cc+IB 200 mg/rat/day (PC+IB group). All groups were received high cholesterol diet for 4 weeks. The blood samples at baseline and the end of this study were used for the lipid profile, superoxide dismutase (SOD), and malondialdehyde (MDA) examination. The result was then analyzed with an Analysis of Variance test. RESULTS: There were significant differences in changes of total cholesterol, Low-density lipoprotein, triglycerides, high-density lipoprotein, MDA, and SOD in the treatment group (PC, IB, PC+IB) compared to the control (p < 0.001). The decrease of MDA and increase of SOD were mainly found in the PC+IB group compared to the PC group and IB group (p < 0.05). The changes in lipid profiles were mainly found in the PC+IB group and PC group compared to the IB group (p < 0.05). CONCLUSION: Administration of PC and IB combination is an effective hypolipidemic agent. This combination has superior antioxidant activity compared to the single-agent (PC or IB) and control.

scholarly journals Effects of cholesterol and Lactobacillus acidophilus on testicular function

2021 ◽  
Vol 48 (3) ◽  
pp. 229-235
Author(s):  
Gülay Çiftci ◽  
Elif Tuna
Keyword(s):  
Lactobacillus Acidophilus ◽  
Testicular Tissue ◽  
Male Rats ◽  
Wall Structure ◽  
Enzyme Linked Immunosorbent Assay ◽  
High Cholesterol Diet ◽  
Standard Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Androgen Binding

Objective: In this study, the effects of Lactobacillus acidophilus on testosterone (TES), follicle-stimulating hormone (FSH), luteinizing hormone (LH), androgen-binding protein (ABP), factor-associated apoptosis (FAS), and total cholesterol (TC), as well as histopathological changes, were investigated in male rats fed a high-cholesterol diet. Methods: The study included three groups. The control (C) group was fed standard-diet for 8 weeks. The hypercholesterolemia (HC) group was fed a 2% cholesterol-diet for 8 weeks. The therapeutic group (HCL) was fed a 2% cholesterol-diet for 8 weeks and administered L. acidophilus for the last 4 weeks. FSH, TES, and FAS levels in testicular tissue were determined using an enzyme-linked immunosorbent assay (ELISA), while another sample was examined histopathologically. LH and ABP levels were determined using ELISA, and serum TC levels were assessed via an autoanalyzer. Results: In the HC group, the TC levels were significantly higher and the LH levels were lower (p<0.05) than in the C group. The ABP levels were lower (p>0.05). In the HCL group, the LH and ABP levels were higher (p>0.05) and the TC level significantly lower (p<0.05) than in the HC group. The TES and FSH levels were lower, and the FAS levels were higher, in the HC than in the C group (p<0.05). In the HCL group, levels of all 3 resembled control levels. Histologically, in the testicular tissue of the HC group, the cells in the tubular wall exhibited atrophy, vacuolization, and reduced wall structure integrity. However, in the HCL group, these deteriorations were largely reversed.Conclusion: Supplementary dietary administration of an L. acidophilus to hypercholesterolemic male rats positively impacted testicular tissue and male fertility hormone levels.

Bovine lactoferrin ameliorates antioxidant esterase activity and 8-isoprostane levels in high-cholesterol-diet fed rats

2017 ◽  
Vol 87 (3-4) ◽  
pp. 201-206 ◽  
Author(s):  
Yousef Faridvand ◽  
Samira Nozari ◽  
Abbas Asoudeh-Fard ◽  
Mohammad-Ali Karimi ◽  
Masoud Pezeshkian ◽  
...  
Keyword(s):  
Normal Diet ◽  
Atherogenic Index ◽  
Male Rats ◽  
Pon1 Activity ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Bovine Lactoferrin ◽  
Cholesterol Diet ◽  
Sprague Dawley ◽  
High Cholesterol

Abstract. The main aim of the present study was to show the effect of bovineLactoferrin (bLF), an 80 kD iron-binding glycoprotein, its application on antioxidant esterase activities and 8-isoprostane changes in high-cholesterol-diet fed (HCD-Fed) rats. The 44 adult Sprague-Dawley male rats were randomly assigned into four experimental groups. They were randomly assigned into four equivalent groups (n = 11). The groups included the control group which was fed with normal diet, bLF group, the third group which were made hypercholesterolemia by being fed with high cholesterol diet, and the last group which consisted of hypercholesterolemia rats treated with bLF (HCD + bLF) for 4 weeks (200 mg.kg−1 per day wt. dissolved in 0.9% normal saline).After 4 weeks, the serum Paraoxonase1 (PON1), Arylesterase (ARE) activity and 8-isoprostane with lipid profile were measured. Upon treatment with the bLF, the decrease in LDL-Cholesterol (LDL-C), Glucoses, Triglyceride (TG) and Total-Cholesterol (TC) levels and an increase in HDL-Cholesterol (HDL-C) level were observed. The co-administration of bLf for 4 weeks had decreased the 8-isoprostane levels significantly (P < 0.001) (86.36 ± 7.1 vs 117.18 ± 8.62) when compared to hypercholesterolemia-induced rats. Also, the Atherogenic Index (AI) in HCD + bLF group showed a significant decrease as compared to the HCD group (P < 0.001) (0.37 ± 0.07 vs 0.57 ± 0.09). The results indicated that bLF was effective against oxidative stress by its ability to increase PON1 activity and reduce the lipid peroxidation in high-cholesterol-fed rats.

scholarly journals LIPID PROFILE;

2017 ◽  
Vol 24 (11) ◽  
pp. 1702-1707
Author(s):  
Ambreen Javed ◽  
Shakir Khan ◽  
Faizania Shabbir ◽  
Tausif Ahmed Rajput ◽  
Abdul Khaliq Naveed
Keyword(s):  
Lipid Profiles ◽  
Male Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Army Medical ◽  
Medical College ◽  
Rat Offspring ◽  
Normal Rat

Objectives: To study the effect of maternal high-fat, high-cholesterol diet on thelipid profiles of rat offspring. Study Design: Randomized control trial (RCT). Place and durationof study: Department of Biochemistry, Army Medical College, Rawalpindi in collaborationwith Chemical Pathology Laboratory (CPL), Army Medical College, Rawalpindi and NationalInstitute of Health (NIH), Islamabad. The study was completed in six months. Material andMethods: Sixty adult female albino rats of Sprague-Dawley strain were divided into two groupsof 30 each. Male rats of the same strain were used for breeding. Ten days before expectedmating experimental group was shifted to a high-fat, high-cholesterol diet, keeping the controlgroup on normal rat diet. Lipid profiles of pregnant dams of both groups were done at day20 of gestation. Offspring of both groups from weaning onwards were fed the normal rat diet.One male and one female offspring from each litter of both groups (30 male and 30 femalesfrom each group) were selected and their lipid profiles were evaluated at post-weaning andadult stage. Results: At day 20 of gestation, high-fat and cholesterol fed dams showed highlysignificant increase in TC, LDL-c, HDL-c and LDL-c / HDL-c ratio than the control dams (p <0.01). Maternal high-fat, high- cholesterol diet was found to raise some parameters of lipidprofiles of the offspring. Conclusions: Maternal high fat and cholesterol diet in pregnancy andlactation causes hyperlipidaemia in the rat offspring.

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