scholarly journals The COSEVAST Study: Unravelling the role of Arterial Stiffness in COVID-19 Disease severity

2020 ◽  
Author(s):  
Sanjeev Kumar ◽  
Neeraj Kumar ◽  
Abhyuday Kumar ◽  
Divendu Bhushan ◽  
Amarjeet Kumar ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Disease Severity ◽  
Pulse Wave ◽  
Cardiovascular Complications ◽  
Endothelial Damage ◽  
Specific Marker ◽  
Non Invasive ◽  
Independent Marker ◽  
Invasive Measurement

AbstractBackgroundBased on the detailed review of available research and case studies reported in reputed international journals, it can be concluded that endothelial damage (En-dotheliitis) both in small and large arteries may be an important factor of morbidity and mortality in COVID-19 patients. Arterial stiffness due to Endothelial Dysfunction has been established as an independent and specific marker of various chronic cardiovascular diseases.ObjectiveOur objective was to examine functional impairment of the arteries in COVID-19 disease and establish the non-invasive measurement of Arterial Stiffness as an independent marker of disease severity.MethodsWe recorded the Arterial Stiffness of 23 Mild, 21 Moderate and 20 Severe COVID-19 patients grouped on latest NIH severity criteria. We observed Arterial Stiffness of COVID-19 patients with standard parameters like non-invasive Carotid-Femoral Pulse Wave velocity (cfPWV), Age-Normalized increase in cfPWV (ANI_cfPWV).ResultsModerate and Severe COVID-19 patients have extremely elevated arterial stiffness than Mild patients. In Mild patients, cfPWV (829.1 ± 139.2 cm/s) was extremely significantly lower than both Moderate (1067 ± 152.5 cm/s, P< 0.0001) and Severe (1416 ± 253.9 cm/s, P < 0.0001) patients. ANI_cfPWV in Moderate and Severe patients was significantly higher than Mild patients. (Mild: 101.2 ± 126.1 cm/s; Moderate: 279 ± 114.4 cm/s; Severe: 580.1 ± 216.4 cm/s; intergroup P <0.0001). Conclusion: Our findings strongly suggest that arterial stiffness can be an independent and accurate marker for objective risk stratification and therapeutic alleviation of the acute cardiovascular complications like MODS in COVID-19.

Markers of arterial stiffness in peripheral arterial disease

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Marc Husmann ◽  
Vincenzo Jacomella ◽  
Christoph Thalhammer ◽  
Beatrice R. Amann-Vesti
Keyword(s):  
Arterial Stiffness ◽  
Peripheral Arterial Disease ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Arterial Disease ◽  
Care Physician ◽  
Additional Information ◽  
Non Invasive ◽  
Assessment Techniques ◽  
Peripheral Arterial

Abstract. Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

scholarly journals Feasibility of non‐invasive measurement of central blood pressure and arterial stiffness in shock

2021 ◽  
Author(s):  
Konstantinos Markakis ◽  
Nikolaos Pagonas ◽  
Eleni Georgianou ◽  
Panagiota Zgoura ◽  
Benjamin J. Rohn ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Central Blood Pressure ◽  
Non Invasive ◽  
Invasive Measurement

NON-INVASIVE MEASUREMENT OF HEART-FEMORAL PULSE WAVE VELOCITY

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e224
Author(s):  
C. Magistri ◽  
F.U.S. Mattace Raso ◽  
F. Battista ◽  
F. Anastasio ◽  
G. Pucci
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Non Invasive ◽  
Invasive Measurement

Detection of Arteries by Using Diffuse Reflectance Photoplethysmography

2010 ◽  
Author(s):  
Shinichiro Ota ◽  
Toshitaka Yasuda ◽  
Takashi Saito
Keyword(s):  
Light Scattering ◽  
Diffuse Reflectance ◽  
Pulse Wave ◽  
Arterial Pulse ◽  
Measurement Condition ◽  
Non Invasive ◽  
Arterial Pulse Wave ◽  
Light Scattering Intensity ◽  
The Difference ◽  
Invasive Measurement

Non-invasive measurement of the arterial pulse wave can be carried out by means of an optical sensor placed at the center of the artery. In this paper, we explore the possibility of using diffuse reflectance photoplethysmography (PPG) for the detection of arteries, a method that allows for the timely detection of changes in the blood pressure. It is believed that the light scattering intensity is affected by the presence of veins in the light path. The purpose of the present study is to elucidate the influence of veins on the accuracy of PPG. In this study, we used light scattering measurements to investigate the difference observed in the performance of PPG (wavelength: 810 and 530 nm) due to the presence of veins. On the basis of these results, we concluded that PPG at a wavelength of 810 nm is more susceptible to the presence of veins than at 530 nm. However, the influence of veins can be reduced by the measurement condition that surrounding veins are being crushed at a wavelength of 810 nm.

Limitations and pitfalls of non-invasive measurement of arterial pressure wave reflections and pulse wave velocity

2009 ◽  
Vol 3 (2) ◽  
pp. 79 ◽  
Author(s):  
Patrick Segers ◽  
Jan Kips ◽  
Bram Trachet ◽  
Abigail Swillens ◽  
Sebastian Vermeersch ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pressure Wave ◽  
Pulse Wave ◽  
Wave Reflections ◽  
Non Invasive ◽  
Invasive Measurement

scholarly journals The increasing of arterial vascular resistance is a primary factor of development isolated systolic hypertensions

2007 ◽  
Vol 13 (1) ◽  
pp. 7-13
Author(s):  
A. A. Sokolov ◽  
M. V. Soldatenko
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Arterial Hypertension ◽  
Vascular Resistance ◽  
Vascular Tone ◽  
Arterial Wall ◽  
Pulse Wave ◽  
Vascular Wall ◽  
Non Invasive ◽  
Modern Methods

In the submitted review value of increase of vascular resistance and a vascular tone in development of an isolated arterial hypertension has been shown. Parameters of elasticity of the arteries, used for the characteristic of properties of a vascular wall are discussed. In the review modern methods non invasive study of the properties of the arterial wall was described. The special attention has been given study of the pulse wave velocity, value of parameters of resistance and arterial stiffness for an estimation of the forecast was shown.

scholarly journals Vascular stiffness in patients with arterial hypertension: possible antihypertensive therapy

2016 ◽  
Vol 13 (2) ◽  
pp. 17-23
Author(s):  
O D Ostroumova ◽  
A I Kochetkov ◽  
M V Lopukhina
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Pulse Wave ◽  
Antihypertensive Drugs ◽  
Vascular Wall ◽  
Cardiovascular Complications ◽  
Increased Risk ◽  
Pharmacokinetic Properties ◽  
Complications And Mortality

The article discusses the factors that increase the arterial stiffness: the blood pressure, atherosclerosis, smoking, diabetes, age. Given evidence that pulse wave velocity and a number of other indicators that reflect the state of the vascular wall, are markers for increased risk of cardiovascular complications and mortality. The influence of antihypertensive drugs of different groups on the stiffness of the vascular wall, with particular attention paid to the effects of drugs from group of diuretics. We discuss possible mechanisms of the influence of indapamide retard on the elastic properties of vessels. It is emphasized that the influence on the stiffness of the arteries of different antigipertenzivny medicines, even belong to the same class, is different, due to differences in pharmacokinetic properties.

scholarly journals The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis

2021 ◽  
Vol 97 (2) ◽  
pp. 16-22
Author(s):  
Zarema R. Khismatullina ◽  
Ksenia M. Koreshkova
Keyword(s):  
Psoriatic Arthritis ◽  
Vascular Wall ◽  
Cardiovascular Complications ◽  
Endothelial Damage ◽  
Very Low Density Lipoproteins ◽  
Cardiovascular Pathology ◽  
Immune Mediated ◽  
Increased Risk ◽  
Complications And Mortality

An increased risk of cardiovascular events has now been identified in patients with psoriatic arthritis. The chronic immune-mediated inflammation underlying psoriatic arthritis (PA) leads to the development of dyslipidemia, atherosclerosis and its complications, in particular, a high risk of cardiovascular complications. For PA, dyslipidemias are most characteristic, manifested by an increased level of low and very low density lipoproteins, triglycerides and total cholesterol, which correlates with the activity of the disease. The literature review studied the pathogenesis of dyslipidemias and vascular wall lesions in psoriatic arthritis, analyzed the literature on cardiovascular complications and mortality among patients with PA, studied the issues of total cardiovascular risk, presented the results of numerous clinical studies that allow PA to be considered a disease associated with increased the risk of cardiovascular complications. Considering the role of proinflammatory cytokines in the pathogenesis of psoriatic arthritis, early detection of endothelial lesions represents the most promising direction in the prevention of cardiovascular diseases, which are the main cause of mortality in this group of patients.

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