scholarly journals The trends in maternal age distribution and the estimated live birth and population prevalence of Down’s syndrome in China: 1985-2012

2021 ◽  
Author(s):  
Jing Kang ◽  
Jianhua Wu
Keyword(s):  
Live Birth ◽  
Maternal Age ◽  
National Level ◽  
Down's Syndrome ◽  
Age Distribution ◽  
Down’S Syndrome ◽  
Birth Prevalence ◽  
Live Births ◽  
The Past ◽  
Population Prevalence

ABSTRACTThis study aims to investigate the trends in maternal age distribution and estimate the live birth and population prevalence of Down’s syndrome in China.Using population survey data, we demonstrated the change of maternal age over the past three decades and its effect on the live birth prevalence of Down’s syndrome. We also integrated the live birth prevalence and the survival rate to estimate the population prevalence of Down’s syndrome. Chi-square test was used to compare the maternal age distributions across survey years.The results show that the maternal age has been rising over the past 30 years in China at national level. The proportion of mothers aged 35 and over increased from 3.62% in 1985 to 14.40% in 2010. The estimated live birth prevalence of Down’s syndrome has mirrored the same increase of the maternal age from 1.07 per 1000 live births in 1985 to 2.36 per 1000 live births in 2010. At City level, the change of maternal age and live birth prevalence of Down’s syndrome were more significant than at Town and County levels. The proportion of mothers aged 35 and over increased from 2.17% in 1995 to about 16% in 2010 at City level, while it increased from 2.03% to 13.65% at County level. The total estimated number of people with Down’s syndrome who were still alive in 2012 and aged below 27 was 611,053, and the estimated population prevalence is 0.45 per 1000.To conclude, this study provides a clear message about the rising trend in maternal age in both urban and rural areas in China since 1985 and its effect on the estimated birth prevalence with Down’s syndrome. The regional differences should be taken into account for planning population policy and allocating medical resources to reduce the burden of family with Down’s syndrome.

scholarly journals Reliability of Statistics on Down's Syndrome Notifications

1997 ◽  
Vol 4 (2) ◽  
pp. 95-97 ◽  
Author(s):  
T Huang ◽  
H C Watt ◽  
N J Wald ◽  
J K Morris ◽  
D Mutton ◽  
...  
Keyword(s):  
Maternal Age ◽  
Antenatal Diagnosis ◽  
Down's Syndrome ◽  
Age Distribution ◽  
Down’S Syndrome ◽  
England And Wales ◽  
Birth Prevalence ◽  
Live Births ◽  
National Statistics ◽  
Using Data

Objectives— To evaluate the completeness of notifications of Down's syndrome live births and terminations to the Office for National Statistics (ONS) using data from the National Down Syndrome Cytogenetic Register (NDSCR). To examine the agreement of observed birth prevalence of Down's syndrome with the expected birth prevalence derived from published maternal age specific rates. Methods— The number of live births (adjusted to allow for the estimated under-ascertainment) and the number of terminations due to fetal Down's syndrome from NDSCR were compared with those figures reported to the ONS. Subsequently, using the NDSCR figures, the live birth prevalence of Down's syndrome that would have occurred in the absence of antenatal diagnosis and selective termination was calculated in England and Wales in the years 1990–1993. These figures were compared with those derived by applying published age specific prevalences to the maternal age distribution in England and Wales. Results— It is estimated that only 48% and 46% respectively of Down's syndrome live births and terminations of pregnancy were notified to ONS between 1990 and 1993. The annual expected birth prevalences of Down's syndrome obtained by applying maternal age specific prevalences to the maternal age distribution were in close agreement with observed rates from NDSCR. Conclusions— There is considerable underreporting of Down's syndrome births and terminations to ONS. The NDSCR data are more complete and therefore the effects of screening should be monitored using data from this source, or using estimates derived from the age specific rates of Down's syndrome.

Corrections to maternal age-specific live birth prevalence of Down's syndrome

2005 ◽  
Vol 12 (4) ◽  
pp. 202-202 ◽  
Author(s):  
Joan Morris ◽  
David Mutton ◽  
Eva Alberman
Keyword(s):  
Live Birth ◽  
Maternal Age ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Birth Prevalence

The incidence of Down's syndrome and progress towards its reduction

1988 ◽  
Vol 319 (1194) ◽  
pp. 315-324 ◽  
Keyword(s):  
Maternal Age ◽  
Down's Syndrome ◽  
Age Groups ◽  
Down’S Syndrome ◽  
Close Relation ◽  
High Rate ◽  
Age Group ◽  
Birth Prevalence ◽  
Considerable Impact ◽  
Exogenous Factors

Down’s syndrome is the most common autosomal aberration and single cause of mental retardation in man. There is a close relation between advanced maternal age and Down’s syndrome. The limitation of family size has made a considerable impact on the incidence of Down’s syndrome. In Denmark in the 1950s, 50% of Down’s syndrome cases were born to mothers over the age of 35. The percentage went down to 25% in the 1970s and was reduced by prenatal diagnosis to 8 % in the 1980s. For the period 1980-85 we followed the birth prevalence closely for the different maternal age groups. The birth prevalence was lowered for the age group over 35, but there was a steady rise for the age groups below 35. Early diagnosis, high rate of survival of light-for-date babies and babies with congenital heart defect, and, possibly, exogenous factors working on gametogenesis might be an explanation. To achieve a reduction in incidence, maternal x-fetoprotein (AFP)-serum screening for low values may be a possibility. So far, avoidance, but not primary prevention, of Down’s syndrome is available.

scholarly journals Maternal Age-Associated Congenital Anomalies Among Newborns: A Retrospective Study in Latvia

Medicina ◽  
2013 ◽  
Vol 49 (1) ◽  
pp. 6 ◽  
Author(s):  
Irisa Zīle ◽  
Anita Villeruša
Keyword(s):  
Retrospective Study ◽  
Live Birth ◽  
Congenital Anomalies ◽  
Prevalence Rate ◽  
Maternal Age ◽  
Birth Prevalence ◽  
Live Births ◽  
Medical Birth Register ◽  
Study Results ◽  
The Mean

Background and Objective. In Latvia, the mean age of women giving birth increased from 27.3 in 2000 to 29.0 years in 2010 during the last 11 years. The aim of this study was to report on major congenital anomalies of newborns at birth by the maternal age and to compare the mean maternal age by different diagnosis subgroups and maternal and neonatal characteristics. Material and Methods. A cross-sectional retrospective study with the data from the Medical Birth Register (2000–2010) was carried out. The live birth prevalence rate was calculated for the subgroups of major congenital anomalies per 10 000 live births by the maternal age. Results. The live birth prevalence rate of major congenital anomalies during the period 2000– 2010 was 211.4 per 10 000 live births. The prevalence rate increased depending on the maternal age. Congenital heart defects, limb defects, and urinary system anomalies were the most common anomalies. The study results showed an age-related risk of abdominal wall defects, orofacial clefts, and chromosomal anomalies. There were significantly higher proportions of preterm births, newborns with low birth weight, and complications during pregnancy among mothers aged 35 years and more. Conclusions. The data on congenital anomalies from the Latvian Medical Birth Register can be used for the assessment of epidemiology of congenital anomalies. The results of this retrospective study showed a decrease in the live birth prevalence rate of major congenital anomalies despite an increase in the mean age of mothers in Latvia.

scholarly journals Prevalence of Down's Syndrome in England, 1998–2013

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
James C Doidge ◽  
Joan K Morris ◽  
Katie L Harron ◽  
Sarah Stevens ◽  
Ruth Gilbert
Keyword(s):  
Data Quality ◽  
Linked Data ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Time Data ◽  
Bias Analysis ◽  
Birth Prevalence ◽  
Live Births ◽  
Quantitative Bias Analysis ◽  
Over Time

IntroductionDisease registers and electronic health records are valuable resources for disease surveillance and research but can be limited by variation in data quality over time. Quality may be limited in terms of the accuracy of clinical information, of the 'internal linkage' that supports person-based analysis of most administrative datasets, or by errors in linkage between multiple datasets. ObjectivesBy linking the National Down Syndrome Cytogenetic Register (NDSCR) to Hospital Episode Statistics for England (HES), we aimed to assess the quality of each and establish a consistent approach for analysis of trends in prevalence of Down’s syndrome among live births in England. MethodsProbabilistic record linkage of NDSCR to HES for the period 1998–2013, supported by linkage of babies to mothers within HES. Comparison of prevalence estimates in England using NDSCR only, HES data only, and linked data. Capture-recapture analysis and quantitative bias analysis were used to account for potential errors, including false positive diagnostic codes, unrecorded diagnoses, and linkage error. ResultsAnalyses of single-source data indicated increasing live birth prevalence of Down’s Syndrome, particularly analysis of HES. Linked data indicated a contrastingly stable prevalence of 12.3 (plausible range: 11.6–12.7) cases per 10 000 live births. ConclusionsCase ascertainment in NDSCR improved slightly over time, creating a picture of slowly increasing prevalence. The emerging epidemic suggested by HES primarily reflects improving linkage within HES (assignment of unique patient identifiers to hospital episodes). Administrative data are valuable but trends should be interpreted with caution, and with assessment of data quality over time. Data linkage with quantitative bias analysis can provide more robust estimation and, in this case, reassurance that prevalence is not increasing. Routine linkage of administrative and register data can enhance the value of each.

Incidence of Down's Syndrome by Maternal Age of Asian Population

2020 ◽  
Author(s):  
Song Yi ◽  
Jieping Song ◽  
Feng Liu ◽  
Xu Liu ◽  
Chengcheng Zhang ◽  
...  
Keyword(s):  
Maternal Age ◽  
Down's Syndrome ◽  
Asian Population ◽  
Down’S Syndrome
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