scholarly journals Predicting arterial age using carotid ultrasound images, pulse wave analysis records, cardiovascular biomarkers and deep learning

2021 ◽  
Author(s):  
Alan Le Goallec ◽  
Sasha Collin ◽  
Samuel Diai ◽  
Theo Vincent ◽  
Chirag J Patel
Keyword(s):  
Blood Pressure ◽  
Deep Learning ◽  
Pulse Wave ◽  
Pulse Wave Analysis ◽  
Arterial System ◽  
Ultrasound Images ◽  
Carotid Ultrasound ◽  
Wave Analysis ◽  
Age Related ◽  
Arterial Aging

Cardiovascular disease --an age-related disease-- is the leading cause of death worldwide. We built an arterial age predictor by training deep learning models to predict age from 233,388 pulse wave analysis records, 8,279 carotid ultrasound images and arterial health biomarkers (e.g blood pressure) collected from 502,000 UKB participants. We predicted age with a R-Squared of 67.1+/-0.6% and a root mean squared error of 4.29+/-0.04 years. Attention maps for carotid ultrasound images suggest that the predictions are driven by vascular features, for the largest part. Accelerated arterial aging is 32.6+/-7.3% GWAS-heritable, and we identified 192 single nucleotide polymorphisms in 109 genes (e.g NPR3, involved in blood volume and pressure) significantly associated with this phenotype. Similarly, we identified biomarkers (e.g electrocardiogram features), clinical phenotypes (e.g chest pain), diseases (e.g hypertension), environmental (e.g smoking) and socioeconomic (e.g income and education) variables associated with accelerated arterial aging. Finally, carotid ultrasound images, pulse wave analysis records and blood pressure biomarkers capture different facets of arterial aging. For example, carotid ultrasound-measured and pulse wave analysis-measured accelerated arterial aging phenotypes are only .164+/-.009 correlated. In conclusion, our predictor suggests potential lifestyle and therapeutic interventions to slow arterial aging, and could be used to assess the efficiency of emerging rejuvenating therapies on the arterial system.

scholarly journals Associations between Intrinsic Heart Rate, P Wave and QT Interval Durations and Pulse Wave Analysis in Patients with Hypertension and High Normal Blood Pressure

2020 ◽  
Vol 17 (12) ◽  
pp. 4350
Author(s):  
Ioana Mozos ◽  
Cristina Gug ◽  
Costin Mozos ◽  
Dana Stoian ◽  
Marius Pricop ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Qt Interval ◽  
Pulse Wave ◽  
Pulse Wave Analysis ◽  
P Wave ◽  
Normal Blood Pressure ◽  
Wave Analysis ◽  
Wave Duration ◽  
P Wave Duration

The present study aimed to explore the relationship between electrocardiographic (ECG) and pulse wave analysis variables in patients with hypertension (HT) and high normal blood pressure (HNBP). A total of 56 consecutive, middle-aged hypertensive and HNBP patients underwent pulse wave analysis and standard 12-lead ECG. Pulse wave velocity (PWV), heart rate, intrinsic heart rate (IHR), P wave and QT interval durations were as follows: 7.26 ± 0.69 m/s, 69 ± 11 beats/minute, 91 ± 3 beats/minute, 105 ± 22 mm and 409 ± 64 mm, respectively. Significant correlations were obtained between PWV and IHR and P wave duration, respectively, between early vascular aging (EVA) and P wave and QT interval durations, respectively. Linear regression analysis revealed significant associations between ECG and pulse wave analysis variables but multiple regression analysis revealed only IHR as an independent predictor of PWV, even after adjusting for blood pressure variables and therapy. Receiver-operating characteristic (ROC) curve analysis revealed P wave duration (area under curve (AUC) = 0.731; 95% CI: 0.569–0.893) as a predictor of pathological PWV, and P wave and QT interval durations were found as sensitive and specific predictors of EVA. ECG provides information about PWV and EVA in patients with HT and HNBP. IHR and P wave durations are independent predictors of PWV, and P wave and QT interval may predict EVA.

scholarly journals The Effect of Dipping Tobacco on Pulse Wave Analysis among Adult Males

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Areeg E. Elemam ◽  
Nisreen D. Omer ◽  
Neima M. Ibrahim ◽  
Ahmed B. Ali
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Pulse Wave ◽  
Pulse Wave Analysis ◽  
Control Group ◽  
Study Group ◽  
Adult Males ◽  
Wave Analysis ◽  
Increased Risk ◽  
Wall Stiffness

Background. The current study investigated the effect of dipping tobacco (DT) use on arterial wall stiffness which is a known marker of increased risk of cardiovascular events. Methods. A case-control study which included 101 adult males was carried out in Al-Shaab Teaching Hospital. Blood pressure and pulse wave analysis parameters were recorded in 51 DT users (study group) before and after 30 minutes of placing tobacco and in 50 nontobacco users (control group). Anthropometric measurements were collected using data collection sheet. Data were entered into a computer and analyzed by using the software Statistical Package for the Social Sciences (SPSS) version 20 (SPSS Inc., Chicago, IL, USA). Results. At baseline measurements, heart rate (HR) was significantly lower in the study group compared to the control group ( 66.15 ± 9.21 vs. 72.87 ± 10.13 beats/min; P value ≤ 0.001). Subendocardial viability ratio (SEVR) was significantly higher in the study group compared to the control group ( 203.44 ± 30.34 vs. 179.11 ± 30.51 % ; P value ≤ 0.001). Acute effects of DT compared to pretobacco dipping showed significant increase in HR ( 72.50 ± 10.89 vs. 66.15 ± 9.21 beats/min; P value ≤ 0.001) and significant decrease in augmentation pressure (AP) (4.30 (2.30-8.00) vs. 3.30 (0.60-6.3) mmHg; P value ≤ 0.001), ejection duration (ED) ( 271.65 ± 19.42 vs. 279.53 ± 20.47   ms ; P value ≤ 0.001), and SEVR ( 187.11 ± 29.81 vs. 203.44 ± 30.34 ; P value ≤ 0.001). Linear regression analysis for AP predictor showed that only HR and AIx@75 affect and predict the values of AP ( Beta ± SE ; − 0.242 ± 0.019 , P value ≤ 0.001; 0.685 ± 0.014 , P value ≤ 0.001). Conclusions. Long-term use of DT was not associated with permanent changes in heart rate and blood pressure. Acute tobacco dipping caused an acute increase in heart rate and oxygen demands of myocardium.

Evaluation of arterial stiffness and central blood pressure by oscillometric method in normotensive offspring of hypertensive parents

2021 ◽  
pp. 1-8
Author(s):  
Cansu Sivrikaya Yildirim ◽  
Pelin Kosger ◽  
Tugcem Akin ◽  
Birsen Ucar
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Diastolic Blood Pressure ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Pulse Wave Analysis ◽  
Control Group ◽  
Study Group ◽  
Wave Analysis

Abstract Children with a family history of hypertension have higher blood pressure and hypertensive pathophysiological changes begin before clinical findings. Here, the presence of arterial stiffness was investigated using central blood pressure measurement and pulse wave analysis in normotensive children with at least one parent with essential hypertension. Twenty-four-hour ambulatory pulse wave analysis monitoring was performed by oscillometric method in a study group of 112 normotensive children of hypertensive parents aged between 7 and 18 comparing with a control group of 101 age- and gender-matched normotensive children of normotensive parents. Pulse wave velocity, central systolic and diastolic blood pressure, systolic, diastolic and mean arterial blood pressure values were higher in the study group than the control group (p < 0.001, p = 0.002, p = 0.008, p = 0.001, p = 0.005, p = 0.001, p = 0.001, respectively). In all age groups (7–10, 11–14, and 15–18 years), pulse wave velocity was higher in the study group than the control group (p < 0.001). Pulse wave velocity was higher in children whose both parents are hypertensive compared to the children whose only mothers are hypertensive (p = 0.011). Pulse wave velocity values were positively correlated with age, weight, height, and body mass index (p < 0.05). Higher pulse wave velocity, central systolic and diastolic blood pressure values detected in the study group can be considered as early signs of hypertensive vascular changes. Pulse wave analysis can be a reliable, non-invasive, and reproducible method that can allow taking necessary precautions regarding lifestyle to prevent disease and target organ damage by detecting early hypertensive changes in genetically risky children.

Automated non-invasive central blood pressure measurements by oscillometric radial pulse wave analysis – results of the MEASURE-cBP validation studies

2020 ◽  
Author(s):  
Frederik Trinkmann ◽  
Urs Benck ◽  
Julian Halder ◽  
Alexandra Semmelweis ◽  
Joachim Saur ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulse Wave ◽  
Applanation Tonometry ◽  
Pulse Wave Analysis ◽  
Central Blood Pressure ◽  
Diabetic Patients ◽  
Radial Pulse ◽  
Wave Analysis ◽  
Operator Training ◽  
Non Invasive

Abstract Background Central blood pressure becomes increasingly accepted as an important diagnostic and therapeutic parameter in the management of cardiovascular disease. This led to development of several non-invasive techniques most commonly based on peripheral pulse wave analysis. Accuracy of widespread applanation tonometry can be affected by calibration and operator training. To overcome this, we aimed to evaluate a novel device (VascAssist 2) using automated oscillometric radial pulse wave analysis and a refined multi-compartment model of the arterial tree. Methods 225 patients were prospectively enrolled. Invasive aortic root measurements served as reference in MEASURE-cBP 1 (n=106) whereas an applanation tonometry device (SphygmoCor) was used in MEASURE-cBP 2 (n=119). Results In MEASURE-cBP 1, we found a mean overestimation for systolic values of 4±12 mmHg (3±10%) and 6±10 mmHg (9±14%) for diastolic values. Diabetes mellitus and low blood pressure were associated with larger variation. In MEASURE-cBP 2, mean overestimation of systolic values was 4±4 mmHg (4±4%) and 1±4 mmHg (1±7%) of diastolic values. Arrhythmia was significantly more frequent in invalid measurements (61 vs. 18%, p&lt;0.0001) which were most often due to a low quality index of SphygmoCor. Accuracy did not differ between patients with arrhythmia and sinus rhythm in MEASURE-cBP 1. Conclusions Central blood pressure estimates using VascAssist 2 can be considered at least as accurate as available techniques, even including diabetic patients. In direct comparison, automated measurement considerably facilitates application not requiring operator training and can be reliably applied even in patients with arrhythmias.

Arterial stiffness assessed by pulse wave analysis in essential hypertension: relation to 24-h blood pressure profile

2005 ◽  
Vol 102 (3) ◽  
pp. 391-395 ◽  
Author(s):  
John P. Lekakis ◽  
Nikos A. Zakopoulos ◽  
Athanasios D. Protogerou ◽  
Theodoros G. Papaioannou ◽  
Vassilios Th. Kotsis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Arterial Stiffness ◽  
Pulse Wave ◽  
Pressure Profile ◽  
Pulse Wave Analysis ◽  
Wave Analysis ◽  
Blood Pressure Profile
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