Evaluation of peripheral enhancement on contrast-enhanced CT and corresponding pathological findings in colorectal liver metastases after preoperative chemotherapy

Objective: To correlate peripheral enhancement on contrast-enhanced computed tomography (CE-CT) of post-chemotherapy colorectal liver metastases (CRLM) patients with the pathological findings. Methods: Forty-four patients with CRLM who underwent hepatic resection after preoperative chemotherapy between 2008 and 2013 were included. Two radiologists blinded to the histopathology findings performed a consensus categorization of the marginal contrast effects of CRLM on CE-CT as follows: Group 1, smooth margin without enhancement; Group 2, smooth margin with an enhanced rim; and Group 3, fuzzy margin with/without an enhanced rim. The Kruskal-Wallis test was used to compare the imaging findings with the histological findings. Results: The percentage of infarct-like necrosis was significantly higher in CRLM with smooth margins than in those with fuzzy margins (p<0.001, r=0.62). The percentage of viable cells was lowest in CRLM with smooth margins without enhancement (p<0.001, r=0.60). Conclusions: Our findings suggest that the type of necrosis is related to the nature of the margins, and the presence of residual cells are related to peripheral enhancement.

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Usefulness of Contrast-Enhanced Intraoperative Ultrasonography (CE-IOUS) in Patients with Colorectal Liver Metastases after Preoperative Chemotherapy

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-012-2043-y ◽

2012 ◽

Vol 17 (2) ◽

pp. 281-287 ◽

Cited By ~ 27

Author(s):

Andrea Ruzzenente ◽

Simone Conci ◽

Calogero Iacono ◽

Alessandro Valdegamberi ◽

Tommaso Campagnaro ◽

...

Keyword(s):

Liver Metastases ◽

Preoperative Chemotherapy ◽

Colorectal Liver Metastases ◽

Intraoperative Ultrasonography ◽

Contrast Enhanced

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Re: Diagnostic performance of contrast-enhanced CT-scan in sinusoidal obstruction syndrome induced by chemotherapy of colorectal liver metastases: Radio-pathological correlation

European Journal of Radiology ◽

10.1016/j.ejrad.2017.12.016 ◽

2018 ◽

Vol 100 ◽

pp. 154 ◽

Cited By ~ 1

Author(s):

Zhuo-qun Huang ◽

Hai-fang Yang ◽

Weilong Lin ◽

Li Xu

Keyword(s):

Liver Metastases ◽

Ct Scan ◽

Colorectal Liver Metastases ◽

Diagnostic Performance ◽

Sinusoidal Obstruction Syndrome ◽

Pathological Correlation ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct

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Diagnostic performance of contrast-enhanced CT-scan in sinusoidal obstruction syndrome induced by chemotherapy of colorectal liver metastases: Radio-pathological correlation

European Journal of Radiology ◽

10.1016/j.ejrad.2017.06.025 ◽

2017 ◽

Vol 94 ◽

pp. 180-190 ◽

Cited By ~ 10

Author(s):

Sophie Cayet ◽

Jeremy Pasco ◽

Fanny Dujardin ◽

Marie Besson ◽

Isabelle Orain ◽

...

Keyword(s):

Liver Metastases ◽

Ct Scan ◽

Colorectal Liver Metastases ◽

Diagnostic Performance ◽

Sinusoidal Obstruction Syndrome ◽

Pathological Correlation ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct

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Contrast Enhanced Ultrasound in the Diagnosis and Evaluation of the Efficiency of Chemotherapy in Patients with Colorectal Liver Metastases

Journal of radiology and nuclear medicine ◽

10.20862/0042-4676-2020-101-6-324-332 ◽

2021 ◽

Vol 101 (6) ◽

pp. 324-332

Author(s):

E. V. Kovaleva ◽

G. T. Sinyukova ◽

T. Yu. Danzanova ◽

P. I. Lepedatu ◽

E. A. Gudilina ◽

...

Keyword(s):

Contrast Agent ◽

Liver Metastases ◽

Colorectal Liver Metastases ◽

Arterial Phase ◽

Contrast Enhanced Ultrasound ◽

Time Curve ◽

Entire Volume ◽

Contrast Enhanced ◽

Group 2 ◽

Group 1

Objective: to determine the possibilities of contrast-enhanced ultrasound (CEUS) in identifying and evaluating the efficiency of chemotherapy in patients with colorectal liver metastases (CLM).Material and methods. The investigation enrolled 28 patients with CLM. The patients were divided into two groups: Group 1 – 15 pretreatment patients; Group 2 – 13 posttreatment patients with process stabilization. All the patients underwent standard B-mode ultrasound of the liver and that using the contrast agent SonoVue ® (Bracco, Italy), by recording and estimating the parameters of the intensity-time curve (CIV). Liver CEUS assesses the nature of contrasting metastases in three phases (arterial, venous, and delay ones).Results. The investigators identified three types of contrast agent accumulation in CLM in the arterial phase: along the periphery of the lesions (in 60% of the patients of Group 1, in 76.9% in Group 2), homogeneously over the entire volume (in 26.7% in Group 1 and in 0.08% in Group 2), in parallel with intact liver parenchyma (13.3% in Group 1 and 23.02% in Group 2). In the delay phase, more metastases were detected in 4 cases (14.3%). Estimation of CIV parameters showed a difference at the beginning of contrast enhancement stages between the patients in both groups. Group 1 exhibited the early contrasting of liver metastases (19.3 sec); Group 2 displayed the late washout of a contrast agent (65.9 sec).Conclusion. CEUS versus B-mode ultrasound improves the imaging of liver metastases. The change in the vascular architectonics and hemodynamics in CLM after chemotherapy is reflected in the alteration of the rate of contrast accumulation and washout from the metastases, which allows CEUS to be used in the evaluation of the efficiency of this treatment.

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