scholarly journals Contrast Enhanced Ultrasound in the Diagnosis and Evaluation of the Efficiency of Chemotherapy in Patients with Colorectal Liver Metastases

2021 ◽  
Vol 101 (6) ◽  
pp. 324-332
Author(s):  
E. V. Kovaleva ◽  
G. T. Sinyukova ◽  
T. Yu. Danzanova ◽  
P. I. Lepedatu ◽  
E. A. Gudilina ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Arterial Phase ◽  
Contrast Enhanced Ultrasound ◽  
Time Curve ◽  
Entire Volume ◽  
Contrast Enhanced ◽  
Group 2 ◽  
Group 1

Objective: to determine the possibilities of contrast-enhanced ultrasound (CEUS) in identifying and evaluating the efficiency of chemotherapy in patients with colorectal liver metastases (CLM).Material and methods. The investigation enrolled 28 patients with CLM. The patients were divided into two groups: Group 1 – 15 pretreatment patients; Group 2 – 13 posttreatment patients with process stabilization. All the patients underwent standard B-mode ultrasound of the liver and that using the contrast agent SonoVue ® (Bracco, Italy), by recording and estimating the parameters of the intensity-time curve (CIV). Liver CEUS assesses the nature of contrasting metastases in three phases (arterial, venous, and delay ones).Results. The investigators identified three types of contrast agent accumulation in CLM in the arterial phase: along the periphery of the lesions (in 60% of the patients of Group 1, in 76.9% in Group 2), homogeneously over the entire volume (in 26.7% in Group 1 and in 0.08% in Group 2), in parallel with intact liver parenchyma (13.3% in Group 1 and 23.02% in Group 2). In the delay phase, more metastases were detected in 4 cases (14.3%). Estimation of CIV parameters showed a difference at the beginning of contrast enhancement stages between the patients in both groups. Group 1 exhibited the early contrasting of liver metastases (19.3 sec); Group 2 displayed the late washout of a contrast agent (65.9 sec).Conclusion. CEUS versus B-mode ultrasound improves the imaging of liver metastases. The change in the vascular architectonics and hemodynamics in CLM after chemotherapy is reflected in the alteration of the rate of contrast accumulation and washout from the metastases, which allows CEUS to be used in the evaluation of the efficiency of this treatment.

scholarly journals Contrast-enhanced ultrasound of kidneys in patients with type 2 diabetes and chronic pyelonephritis: a new dosage of the contrast-enhanced agent

2021 ◽  
Author(s):  
A.V. Borsukov ◽  
S.B. Krukovskiy ◽  
L.N. Markelova ◽  
O.A. Gorbatenko ◽  
D.Yu. Venidiktova
Keyword(s):  
Contrast Agent ◽  
Ultrasound Examination ◽  
Chronic Pyelonephritis ◽  
Contrast Enhanced Ultrasound ◽  
Diagnostic Efficacy ◽  
Contrast Enhanced ◽  
Group 2 ◽  
Improved Technique ◽  
Medical University ◽  
Group 1

Objective. To evaluate the diagnostic efficacy of the contrast-enhanced ultrasound examination of kidneys in patients with chronic pyelonephritis with a dose of injected contrast agent – 1.0 ml. Materials and methods. In 2020, 20 patients with chronic pyelonephritis were examined on the basis of the Fundamental research laboratory “Diagnostic Researches and Minimally Invasive Technologies”, Smolensk State Medical University. All patients underwent ultrasound examination Doppler mapping mode of the kidneys and the. Also, all patients underwent contrast-enhanced ultrasound examination of the kidneys for the diagnosis of angionephrosclerosis. Results. Using the improved technique in patients of group 2 compared with patients in group 1, the quality of the images obtained was preserved. In patients of group 1 with chronic pyelonephritis, the quantitative indicators correspond to the initial manifestations of angionephrosclerosis. Conclusion. Thus, the improved CEUS technique with the use of 1.0 ml of contrast agent showed good possibilities in the diagnosis of angionephrosclerosis in patients with chronic pyelonephritis.

Liver Resection or Resection plus Intraoperative Echo-Guided Ablation in the Treatment of Colorectal Metastases: We are Evaluating Their Effect for Cure

2018 ◽  
Vol 84 (9) ◽  
pp. 1509-1517
Author(s):  
Antonio Chiappa ◽  
Diego Foschi ◽  
Gabriella Pravettoni ◽  
Federico Ambrogi ◽  
Nicola Fazio ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Hepatic Resection ◽  
Colorectal Liver Metastases ◽  
Disease Free Survival ◽  
Oncologic Outcome ◽  
Colorectal Metastases ◽  
Multiple Metastases ◽  
Group 2 ◽  
Group 1

This study determines the oncologic outcome of the combined resection and ablation strategy for colorectal liver metastases. Between January 1994 and December 2015, 373 patients underwent surgery for colorectal liver metastases. There were 284 patients who underwent hepatic resection only (Group 1) and 83 hepatic resection plus ablation (Group 2). Group 2 patients had a higher incidence of multiple metastases (100% in Group 2 vs 28.2% in Group 1; P < 0.001) and bilobar involvement (76.5% in Group 2 vs 12.9% in Group 1; P < 0.001) than Group 1 cases. Perioperative mortality was nil in either group, with a higher postoperative complication rate among Group 1 versus Group 2 cases (18 vs 0, respectively). The median follow-up was 90 months (range, 1–180), with a five-year overall survival for Group 1 and Group 2 of 51 per cent and 80 per cent, respectively (P = 0.193). Mean disease-free survival for patients with R0 resection was 55 per cent, 40 per cent, and 37 per cent at one, two, and three years, respectively, and remained steadily higher (at 50%) in those patients treated with resection combined with ablation up to five years (P = 0.069). The only intraoperative ablation failure was for a large lesion (≥5 cm). Our data support the use of intraoperative ablation when complete hepatic resection cannot be achieved.

Conventional and contrast-enhanced ultrasound features in sclerosing adenosis and correlation with pathology

2020 ◽  
pp. 1-9
Author(s):  
Sihui Shao ◽  
Minghua Yao ◽  
Xin Li ◽  
Chunxiao Li ◽  
Jing Chen ◽  
...  
Keyword(s):  
Imaging Features ◽  
Contrast Enhanced Ultrasound ◽  
Exact Test ◽  
Contrast Enhanced ◽  
Chi Squared ◽  
Group 2 ◽  
Student’S T ◽  
Sensitivity Specificity ◽  
Sclerosing Adenosis ◽  
Group 1

OBJECTIVES: To evaluate the efficacy of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in differential diagnosis of sclerosing adenosis (SA) from malignance and investigate the correlated features with pathology. METHODS: We retrospectively enrolled 103 pathologically confirmed SA. All lesions were evaluated with conventional US while 31 lesions with CEUS. Lesions were divided into SA with or without benign lesions (Group 1, n = 81) and SA with malignancy (Group 2, n = 22). Performance of two methods were analyzed. The ultrasonographic characteristics were compared between two groups with Student’s t-test for measurement and chi-squared or Fisher’s exact test for count data. RESULTS: There were 22 lesions complicated with malignancy, and the mean age of Group 2 was higher than Group 1 (55.27 vs. 41.57, p <  0.001). The sensitivity, specificity and accuracy of conventional US and CEUS were 95.45%, 46.91%, 57.28% and 100%, 62.5%, 70.97%. Angularity (p <  0.001), spicules (p = 0.023), calcification (p = 0.026) and enlarged scope (p = 0.012) or crab claw-like enhancement (p = 0.008) in CEUS were more frequent detected in SA with malignancy. CONCLUSIONS: Though CEUS showed an improved accuracy, the performance of ultrasound in the diagnosis of SA was limited. Awareness and careful review of the histopathologically related imaging features can be helpful in the diagnosis of SA.

scholarly journals Contrast-Enhanced Ultrasound in Residual Tumor of Hepatocellular Carcinoma following Transarterial Chemoembolization: Is It Helpful for Tumor Response?

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Tian’an Jiang ◽  
Qiyu Zhao ◽  
Min Huang ◽  
Junhui Sun ◽  
Guo Tian
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rise Time ◽  
Transarterial Chemoembolization ◽  
Residual Tumor ◽  
Arterial Phase ◽  
Peak Time ◽  
Enhancement Pattern ◽  
Contrast Enhanced ◽  
Group 2 ◽  
Group 1

Aim. To investigate the enhancement pattern of residual tumor on contrast-enhanced ultrasonography (CEUS) in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE).Methods. Our study initially included 76 patients with HCC, 73 of which were finally allocated into two groups: group 1 (43 patients, post-TACE group) and group 2 (30 patients, untreated HCC group). All patients were performed with CEUS using SonoVue, and qualitative and quantitative enhancement characteristics (rise time, peak time, and washout time) were evaluated for the residual tumors. T test orχ2test was used to estimate for differences between two groups.Results. In group 1, the mean rise time, peak time, and washout times in group 1 were 16.1±2.7 sec, 31.3±3.1 sec, and 191.0±31.3 sec, respectively. In group 2, these were 15.1±3.5 sec, 30.9±3.2 sec, and 142.6±16.1 sec, respectively. The differences in rise time and peak time were not statistically significant (P=0.09 and 0.30, respectively), but the washout time was significantly prolonged in group 1 (P<0.01). The enhanced pattern in arterial phase was inhomogeneous (n=11), regular homogeneous (n=11), partial (n=12), peripheral (n=7), and peripheral rim-like (n=2) in group 1. The average of the longest tumor size of the whole lesion in the 5 types was 4.7±1.3cm, 2.9±1.0cm, 3.1±1.7cm, 2.5±0.6cm, and 2.1 cm.Conclusion. It suggested that the washout time of post-TACE residual lesions was prolonged compared with untreated HCC nodules on CEUS imaging. Combined with the triple-phase enhancement pattern seen on CEUS, the washout time may provide additional information to guide further treatment for residual tumors.

scholarly journals Detection of neuroendocrine tumours in the small intestines using contrast-enhanced multiphase Ga-68 DOTATOC PET/CT: the potential role of arterial hyperperfusion

2014 ◽  
Vol 48 (2) ◽  
pp. 120-126 ◽  
Author(s):  
Nils F. Schreiter ◽  
Martin Maurer ◽  
Ulrich-Frank Pape ◽  
Bernd Hamm ◽  
Winfried Brenner ◽  
...  
Keyword(s):  
Ct Scan ◽  
False Positive ◽  
Neuroendocrine Tumours ◽  
Arterial Phase ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Medicine Physician ◽  
Group 2 ◽  
Group 1

Abstract Background. Interpretation of small intestinal neuroendocrine tumours (NETs) by Ga-68 DOTATOC PET/CT can be difficult. The potential benefit of arterial hyperperfusion for the detection of NETs was evaluated. Methods. Between 2006 and 2009, 320 consecutive Ga-68 DOTATOC PET/CT examinations, performed for NETs, revealed 40 lesions suggesting intestinal NETs in 25 patients. Two groups of lesions were distinguished: epigastric lesions evaluable in the arterial and venous CT scan (Group 1) and hypogastrial lesions evaluable in the venous CT scan only (Group 2). Lesions were jointly rated by two radiologists and a nuclear medicine physician. Maximum standard uptake values (SUVmax) of lesions and background were assessed. The reference standard was histology (available for 28 lesions) or follow-up (for a mean of 22.9 months). Results. PET detected all suspicious lesions but was false positive in 3 lesions. In Group 1 the arterial scan performed significantly better than the venous scan (p = 0.008). Diagnostic performance was better in Group 1 than in Group 2 (p < 0.001). SUVmax of true positive lesions were significantly higher than background SUVmax (p < 0.001) and SUVmax of false positive lesions (p = 0.005). Conclusions. The arterial phase of multiphase Ga-68 DOTATOC PET/CT might improve the localization of intestinal NETs and, thereby, improve the overall diagnostic accuracy of this modality in the assessment of intestinal NETs by adding information about lesion perfusion not available when only venous CT is performed

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