scholarly journals Cingulate dependent social risk assessment in rats

2018 ◽  
Author(s):  
Yingying Han ◽  
Rune Bruls ◽  
Rajat Mani Thomas ◽  
Vasiliki Pentaraki ◽  
Naomi Jelinek ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Granger Causality ◽  
Bayesian Model ◽  
Information Transfer ◽  
Model Comparison ◽  
Social Transmission ◽  
Anterior Cingulate ◽  
Social Risk ◽  
Similar Extent ◽  
Bayesian Model Comparison

AbstractSocial transmission of distress has been conceived of as a one-way phenomenon in which an observer catches the emotions of another. Here we use a paradigm in which an observer rat witnesses another receive electro-shocks. Bayesian model comparison and Granger causality argue against this one-way vision in favor of bidirectional information transfer: how the observer reacts to the demonstrator’s distress influences the behavior of the demonstrator. Intriguingly, this was true to a similar extent across highly familiar and entirely unfamiliar rats. Injecting muscimol in the anterior cingulate of observers reduced freezing in the observers and in the demonstrators receiving the shocks. That rats share the distress of unfamiliar strains is at odds with evolutionary thinking that empathy should be biased towards close individuals. Using simulations, we support the complementary notion that distress transmission could be selected to more efficiently detect dangers in a group.

Bayesian model comparison

2014 ◽  
pp. 101-117
Author(s):  
Michael D. Lee ◽  
Eric-Jan Wagenmakers
Keyword(s):  
Bayesian Model ◽  
Model Comparison ◽  
Bayesian Model Comparison

scholarly journals A Bayesian model comparison approach to test the specificity of visual integration impairment in schizophrenia or psychosis

2018 ◽  
Vol 265 ◽  
pp. 271-278 ◽  
Author(s):  
Tyler B. Grove ◽  
Beier Yao ◽  
Savanna A. Mueller ◽  
Merranda McLaughlin ◽  
Vicki L. Ellingrod ◽  
...  
Keyword(s):  
Bayesian Model ◽  
Model Comparison ◽  
Visual Integration ◽  
Bayesian Model Comparison ◽  
Comparison Approach

Uncertainty of prior and posterior model probability: Implications for interpreting Bayes factors

2021 ◽  
Author(s):  
John K. Kruschke
Keyword(s):  
Posterior Distribution ◽  
Bayesian Model ◽  
Model Comparison ◽  
Bayes Factor ◽  
Bayes Factors ◽  
Prior Model ◽  
Bayesian Hypothesis Testing ◽  
Bayesian Model Comparison ◽  
Posterior Model Probability ◽  
Model Probability

In most applications of Bayesian model comparison or Bayesian hypothesis testing, the results are reported in terms of the Bayes factor only, not in terms of the posterior probabilities of the models. Posterior model probabilities are not reported because researchers are reluctant to declare prior model probabilities, which in turn stems from uncertainty in the prior. Fortunately, Bayesian formalisms are designed to embrace prior uncertainty, not ignore it. This article provides a novel derivation of the posterior distribution of model probability, and shows many examples. The posterior distribution is useful for making decisions taking into account the uncertainty of the posterior model probability. Benchmark Bayes factors are provided for a spectrum of priors on model probability. R code is posted at https://osf.io/36527/. This framework and tools will improve interpretation and usefulness of Bayes factors in all their applications.

Combined-chain nested sampling for efficient Bayesian model comparison

2017 ◽  
Vol 70 ◽  
pp. 84-93 ◽  
Author(s):  
R. Wesley Henderson ◽  
Paul M. Goggans ◽  
Lei Cao
Keyword(s):  
Bayesian Model ◽  
Model Comparison ◽  
Nested Sampling ◽  
Bayesian Model Comparison

scholarly journals Capturing Ordinal Theoretical Constraint in Psychological Science

2018 ◽  
Author(s):  
Julia M. Haaf ◽  
Fayette Klaassen ◽  
Jeffrey Rouder
Keyword(s):  
Social Sciences ◽  
Linear Model ◽  
Bayesian Model ◽  
Model Comparison ◽  
Social Scientists ◽  
Psychological Science ◽  
Bayesian Model Comparison ◽  
Comparison Approach ◽  
The Social ◽  
Ordinal Level

Most theories in the social sciences are verbal and provide ordinal-level predictions for data. For example, a theory might predict that performance is better in one condition than another, but not by how much. One way of gaining additional specificity is to posit many ordinal constraints that hold simultaneously. For example a theory might predict an effect in one condition, a larger effect in another, and none in a third. We show how common theoretical positions naturally lead to multiple ordinal constraints. To assess whether multiple ordinal constraints hold in data, we adopt a Bayesian model comparison approach. The result is an inferential system that is custom-tuned for the way social scientists conceptualize theory, and that is more intuitive and informative than current linear-model approaches.

scholarly journals Intermittent Hormone Therapy Models Analysis and Bayesian Model Comparison for Prostate Cancer

2021 ◽  
Vol 84 (1) ◽  
Author(s):  
S. Pasetto ◽  
H. Enderling ◽  
R. A. Gatenby ◽  
R. Brady-Nicholls
Keyword(s):  
Prostate Cancer ◽  
Bayesian Model ◽  
Model Comparison ◽  
Locally Advanced ◽  
Basin Of Attraction ◽  
Specific Antigen ◽  
Resistance Mechanisms ◽  
Patient Specific ◽  
Response Dynamics ◽  
Bayesian Model Comparison

AbstractThe prostate is an exocrine gland of the male reproductive system dependent on androgens (testosterone and dihydrotestosterone) for development and maintenance. First-line therapy for prostate cancer includes androgen deprivation therapy (ADT), depriving both the normal and malignant prostate cells of androgens required for proliferation and survival. A significant problem with continuous ADT at the maximum tolerable dose is the insurgence of cancer cell resistance. In recent years, intermittent ADT has been proposed as an alternative to continuous ADT, limiting toxicities and delaying time-to-progression. Several mathematical models with different biological resistance mechanisms have been considered to simulate intermittent ADT response dynamics. We present a comparison between 13 of these intermittent dynamical models and assess their ability to describe prostate-specific antigen (PSA) dynamics. The models are calibrated to longitudinal PSA data from the Canadian Prospective Phase II Trial of intermittent ADT for locally advanced prostate cancer. We perform Bayesian inference and model analysis over the models’ space of parameters on- and off-treatment to determine each model’s strength and weakness in describing the patient-specific PSA dynamics. Additionally, we carry out a classical Bayesian model comparison on the models’ evidence to determine the models with the highest likelihood to simulate the clinically observed dynamics. Our analysis identifies several models with critical abilities to disentangle between relapsing and not relapsing patients, together with parameter intervals where the critical points’ basin of attraction might be exploited for clinical purposes. Finally, within the Bayesian model comparison framework, we identify the most compelling models in the description of the clinical data.

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