scholarly journals Region-specific expression of young small-scale duplications in the human central nervous system

2019 ◽  
Author(s):  
Solène Brohard-Julien ◽  
Vincent Frouin ◽  
Vincent Meyer ◽  
Smahane Chalabi ◽  
Jean-François Deleuze ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Evolution ◽  
Tissue Expression ◽  
Small Scale ◽  
Human Central Nervous System ◽  
Specific Expression ◽  
Regional Specialization ◽  
Genome Duplications

ABSTRACTBackgroundThe duplication of genes is one of the main genetic mechanisms that led to the gain in complexity of biological tissue. Although the implication of duplicated gene expression in brain evolution was extensively studied through comparisons between organs, their role in the regional specialization of the adult human central nervous system has not yet been well described.ResultsOur work explored intra-organ expression properties of paralogs through multiple territories of the human central nervous system (CNS) using transcriptome data generated by the Genotype-Tissue Expression (GTEx) consortium. Interestingly, we found that paralogs were associated with region-specific expression in CNS, suggesting their involvement in the differentiation of these territories. Beside the influence of gene expression level on region-specificity, we observed the contribution of both duplication age and duplication type to the CNS region-specificity of paralogs. Indeed, we found that small scale duplicated genes (SSDs) and in particular ySSDs (SSDs younger than the 2 rounds of whole genome duplications) were more CNS region-specific than other paralogs. Next, by studying the two paralogs of ySSD pairs, we observed that when they were region-specific, they tend to be specific to the same region more often than for other paralogs, showing the high co-expression of ySSD pairs. Extension of this analysis to families of paralogs showed that the families with co-expressed gene members (i.e. homogeneous families) were enriched in ySSDs. Furthermore, these homogeneous families tended to be region-specific families, where the majority of their gene members were specifically expressed in the same region.ConclusionsOverall, our study suggests the major involvement of ySSDs in the differentiation of human central nervous system territories. Therefore, we show the relevance of exploring region-specific expression of paralogs at the intra-organ level.

scholarly journals Region-specific expression of young small-scale duplications in the human central nervous system

2020 ◽  
Author(s):  
Solène Brohard ◽  
Vincent Frouin ◽  
Vincent Meyer ◽  
Smahane Chalabi ◽  
Jean-François Deleuze ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Evolution ◽  
Tissue Expression ◽  
Small Scale ◽  
Human Central Nervous System ◽  
Specific Expression ◽  
Regional Specialization ◽  
Genome Duplications

Abstract Background: The duplication of genes is one of the main genetic mechanisms that led to the gain in complexity of biological tissue. Although the implication of duplicated gene expression in brain evolution was extensively studied through comparisons between organs, their role in the regional specialization of the adult human central nervous system has not yet been well described. Results: Our work explored intra-organ expression properties of paralogs through multiple territories of the human central nervous system (CNS) using transcriptome data generated by the Genotype-Tissue Expression (GTEx) consortium. Interestingly, we found that paralogs were associated with region-specific expression in CNS, suggesting their involvement in the differentiation of these territories. Beside the influence of gene expression level on region-specificity, we observed the contribution of both duplication age and duplication type to the CNS region-specificity of paralogs. Indeed, we found that small scale duplicated genes (SSDs) and in particular ySSDs ( SSDs younger than the 2 rounds of whole genome duplications ) were more CNS region-specific than other paralogs. Next, by studying the two paralogs of ySSD pairs, we observed that when they were region-specific, they tend to be specific to the same region more often than for other paralogs, showing the high co-expression of ySSD pairs. Extension of this analysis to families of paralogs showed that the families with co-expressed gene members (i.e. homogeneous families) were enriched in ySSDs. Furthermore, these homogeneous families tended to be region-specific families, where the majority of their gene members were specifically expressed in the same region. Conclusions: Overall, our study suggests the major involvement of ySSDs in the differentiation of human central nervous system territories. Therefore, we show the relevance of exploring region-specific expression of paralogs at the intra-organ level.

scholarly journals Region-specific expression of young small-scale duplications in the human central nervous system

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Solène Brohard-Julien ◽  
Vincent Frouin ◽  
Vincent Meyer ◽  
Smahane Chalabi ◽  
Jean-François Deleuze ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Evolution ◽  
Tissue Expression ◽  
Small Scale ◽  
Human Central Nervous System ◽  
Specific Expression ◽  
Regional Specialization ◽  
Genome Duplications

Abstract Background The duplication of genes is one of the main genetic mechanisms that led to the gain in complexity of biological tissue. Although the implication of duplicated gene expression in brain evolution was extensively studied through comparisons between organs, their role in the regional specialization of the adult human central nervous system has not yet been well described. Results Our work explored intra-organ expression properties of paralogs through multiple territories of the human central nervous system (CNS) using transcriptome data generated by the Genotype-Tissue Expression (GTEx) consortium. Interestingly, we found that paralogs were associated with region-specific expression in CNS, suggesting their involvement in the differentiation of these territories. Beside the influence of gene expression level on region-specificity, we observed the contribution of both duplication age and duplication type to the CNS region-specificity of paralogs. Indeed, we found that small scale duplicated genes (SSDs) and in particular ySSDs (SSDs younger than the 2 rounds of whole genome duplications) were more CNS region-specific than other paralogs. Next, by studying the two paralogs of ySSD pairs, we observed that when they were region-specific, they tend to be specific to the same region more often than for other paralogs, showing the high co-expression of ySSD pairs. The extension of this analysis to families of paralogs showed that the families with co-expressed gene members (i.e. homogeneous families) were enriched in ySSDs. Furthermore, these homogeneous families tended to be region-specific families, where the majority of their gene members were specifically expressed in the same region. Conclusions Overall, our study suggests the involvement of ySSDs in the differentiation of human central nervous system territories. Therefore, we show the relevance of exploring region-specific expression of paralogs at the intra-organ level.

Thrombopoietin gene expression in the developing human central nervous system

2003 ◽  
Vol 143 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Christof Dame ◽  
Eva-Maria Wolber ◽  
Patricia Freitag ◽  
Dietmar Hofmann ◽  
Peter Bartmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Human Central Nervous System

scholarly journals Modulation of Gene Expression in Human Central Nervous System Tumors under Methionine Deprivation-induced Stress

2004 ◽  
Vol 64 (20) ◽  
pp. 7513-7525 ◽  
Author(s):  
Demetrius M. Kokkinakis ◽  
Xiaoyan Liu ◽  
Sunil Chada ◽  
Mansoor M. Ahmed ◽  
Mohammed M. Shareef ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumors ◽  
Human Central Nervous System ◽  
Nervous System Tumors ◽  
Induced Stress ◽  
Modulation Of Gene Expression

scholarly journals Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Martin M. Johansson ◽  
Elin Lundin ◽  
Xiaoyan Qian ◽  
Mohammadreza Mirzazadeh ◽  
Jonatan Halvardson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Sexual Dimorphism ◽  
Human Central Nervous System ◽  
Male Development

Erythropoietin gene expression in different areas of the developing human central nervous system

2000 ◽  
Vol 125 (1-2) ◽  
pp. 69-74 ◽  
Author(s):  
Christof Dame ◽  
Peter Bartmann ◽  
Eva-Maria Wolber ◽  
Hubert Fahnenstich ◽  
Dietmar Hofmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Human Central Nervous System

scholarly journals Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System

mBio ◽  
2021 ◽  
Author(s):  
Chen-Hsin Yu ◽  
Poppy Sephton-Clark ◽  
Jennifer L. Tenor ◽  
Dena L. Toffaletti ◽  
Charles Giamberardino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Human Central Nervous System ◽  
Content Type ◽  
The Central Nervous System

Cryptococcus is the most common fungus causing high-morbidity and -mortality human meningitis. This encapsulated yeast has a unique propensity to travel to the central nervous system to produce disease.

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