scholarly journals Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

1996 ◽  
Vol 10 (12) ◽  
pp. 1467-1478 ◽  
Author(s):  
V Hatini ◽  
S O Huh ◽  
D Herzlinger ◽  
V C Soares ◽  
E Lai
Keyword(s):  
Transcription Factor ◽  
Essential Role ◽  
Targeted Disruption ◽  
Winged Helix ◽  
Winged Helix Transcription Factor ◽  
Kidney Morphogenesis

XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm

Development ◽  
1998 ◽  
Vol 125 (24) ◽  
pp. 4889-4900 ◽  
Author(s):  
C. Bourguignon ◽  
J. Li ◽  
N. Papalopulu
Keyword(s):  
Transcription Factor ◽  
Neuronal Differentiation ◽  
Neural Plate ◽  
High Dose ◽  
Expression Domain ◽  
Dual Effect ◽  
Winged Helix ◽  
Winged Helix Transcription Factor ◽  
Anterior Neural Plate

Neuronal differentiation in the vertebrate nervous system is temporally and spatially controlled by mechanisms which are largely unknown. Here we investigate the role of XBF-1, an anterior neural plate-specific winged helix transcription factor, in controlling the pattern of neurogenesis in Xenopus ectoderm. We show that, in the anterior neural plate of normal embryos, prospective neurogenesis is positioned at the anterior boundary of the XBF-1 expression domain. By misexpressing XBF-1 in the posterior neural plate we show that a high dose of XBF-1 has a dual effect; it suppresses endogenous neuronal differentiation in high expressing cells and induces ectopic neuronal differentiation in adjacent cells. In contrast, a low dose of XBF-1 does not suppress but instead, expands the domain of neuronal differentiation in the lateral and ventral sides of the embryo. XBF-1 regulates the expression of XSox3, X-ngnr-1, X-Myt-1 and X-Δ-1 suggesting that it acts early in the cascade leading to neuronal differentiation. A fusion of XBF-1 to a strong repressor domain (EnR) mimics most of the XBF-1 effects suggesting that the wild type XBF-1 is a transcriptional repressor. However, fusion of XBF-1 to a strong activation domain (E1A) specifically suppresses neuronal differentiation suggesting that XBF-1 may also work as a transcriptional activator. Based on these findings, we propose that XBF-1 is involved in positioning neuronal differentiation by virtue of its concentration dependent, dual activity, as a suppressor and an activator of neurogenesis.

Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus

Development ◽  
2000 ◽  
Vol 127 (5) ◽  
pp. 1029-1038 ◽  
Author(s):  
G. Alvarez-Bolado ◽  
X. Zhou ◽  
A.K. Voss ◽  
T. Thomas ◽  
P. Gruss
Keyword(s):  
Transcription Factor ◽  
Transcriptional Activity ◽  
Wild Type ◽  
Winged Helix ◽  
Targeted Mutation ◽  
Ventricular Cells ◽  
Winged Helix Transcription Factor ◽  
Mutant Cells ◽  
Correct Expression

Our aim was to study the mechanisms of brain histogenesis. As a model, we have used the role of winged helix transcription factor gene Foxb1 in the emergence of a very specific morphological trait of the diencephalon, the mammillary axonal complex. Foxb1 is expressed in a large hypothalamic neuronal group (the mammillary body), which gives origin to a major axonal bundle with branches to thalamus, tectum and tegmentum. We have generated mice carrying a targeted mutation of Foxb1 plus the tau-lacZ reporter. In these mutants, a subpopulation of dorsal thalamic ventricular cells “thalamic palisade” show abnormal persistence of Foxb1 transcriptional activity; the thalamic branch of the mammillary axonal complex is not able to grow past these cells and enter the thalamus. The other two branches of the mammillary axonal complex (to tectum and tegmentum) are unaffected by the mutation. Most of the neurons that originate the mammillothalamic axons suffer apoptosis after navigational failure. Analysis of chimeric brains with wild-type and Foxb1 mutant cells suggests that correct expression of Foxb1 in the thalamic palisade is sufficient to rescue the normal phenotype. Our results indicate that Foxb1 is essential for diencephalic histogenesis and that it exerts its effects by controlling access to the target by one particular axonal branch.

scholarly journals Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4

Development ◽  
2003 ◽  
Vol 130 (19) ◽  
pp. 4539-4552 ◽  
Author(s):  
Perry J. Blackshear ◽  
Joan P. Graves ◽  
Deborah J. Stumpo ◽  
Inma Cobos ◽  
John L. R. Rubenstein ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcript Variant ◽  
Winged Helix ◽  
Specific Transcript ◽  
Phenotypic Response ◽  
Winged Helix Transcription Factor

scholarly journals The Winged Helix Transcription Factor Foxa3 Regulates Adipocyte Differentiation and Depot-Selective Fat Tissue Expansion

2013 ◽  
Vol 33 (17) ◽  
pp. 3392-3399 ◽  
Author(s):  
Lingyan Xu ◽  
Valentine Panel ◽  
Xinran Ma ◽  
Chen Du ◽  
Lynne Hugendubler ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Adipocyte Differentiation ◽  
Tissue Expansion ◽  
Fat Tissue ◽  
Winged Helix ◽  
Winged Helix Transcription Factor

scholarly journals Nucleosome positioning by the winged helix transcription factor HNF3

1998 ◽  
Vol 12 (1) ◽  
pp. 5-10 ◽  
Author(s):  
E. Y. Shim ◽  
C. Woodcock ◽  
K. S. Zaret
Keyword(s):  
Transcription Factor ◽  
Nucleosome Positioning ◽  
Winged Helix ◽  
Winged Helix Transcription Factor

scholarly journals Crystal Structure of the Virulence Gene Activator AphA fromVibrio choleraeReveals It Is a Novel Member of the Winged Helix Transcription Factor Superfamily

2005 ◽  
Vol 280 (14) ◽  
pp. 13779-13783 ◽  
Author(s):  
Rukman S. De Silva ◽  
Gabriela Kovacikova ◽  
Wei Lin ◽  
Ronald K. Taylor ◽  
Karen Skorupski ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Transcription Factor ◽  
Virulence Gene ◽  
Winged Helix ◽  
Winged Helix Transcription Factor

scholarly journals Essential Role of the Transcription Factor Ets-2 inXenopusEarly Development

2002 ◽  
Vol 278 (7) ◽  
pp. 5473-5477 ◽  
Author(s):  
Kaoru Kawachi ◽  
Norihisa Masuyama ◽  
Eisuke Nishida
Keyword(s):  
Transcription Factor ◽  
Essential Role
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