Localization of pp60src within Normal Rat Kidney Cells Infected with Temperature-sensitive Mutants (T-class) of Rous Sarcoma Virus

1980 ◽  
Vol 44 (0) ◽  
pp. 1013-1022
Author(s):  
L. R. Rohrschneider
Keyword(s):  
Rous Sarcoma Virus ◽  
Rat Kidney ◽  
Temperature Sensitive ◽  
Kidney Cells ◽  
Temperature Sensitive Mutants ◽  
Rous Sarcoma ◽  
Normal Rat ◽  
Sarcoma Virus

scholarly journals Differential sensitivity of RSVts (temperature-sensitive Rous-sarcoma virus)-infected rat kidney cells to nucleoside antibiotics at permissive and non-permissive temperatures

1985 ◽  
Vol 232 (3) ◽  
pp. 825-831 ◽  
Author(s):  
Y Uehara ◽  
M Hasegawa ◽  
M Hori ◽  
H Umezawa
Keyword(s):  
Transport System ◽  
Rous Sarcoma Virus ◽  
Rat Kidney ◽  
Temperature Sensitive ◽  
Kidney Cells ◽  
Permissive Temperature ◽  
Nucleoside Antibiotics ◽  
Rous Sarcoma ◽  
Sarcoma Virus ◽  
Thymidine Transport

Among a variety of anti-tumour agents tested, oxanosine and 5-azacytidine were found to be significantly more effective in inhibiting growth of rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus at a permissive temperature (33 degrees C) than at a non-permissive temperature (39 degrees C). These two nucleoside antibiotics were antagonistic to each other in cytotoxicity. They seem to share the same carrier-mediated membrane-transport system, because dipyridamole, a potent inhibitor of nucleoside transport, protected cells from the cytotoxicity of both drugs. Thymidine transport, which is twice as fast in cells at 33 degrees C as at 39 degrees C, was competitively inhibited by both drugs. Thus the differential toxicity of oxanosine and 5-azacytidine at the two temperatures is thought to be due to their increased transport via the thymidine-transport system, which is somehow under the influence of the active src-gene product.

Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells

FEBS Letters ◽  
1991 ◽  
Vol 279 (1) ◽  
pp. 132-136 ◽  
Author(s):  
Kazuo Umezawa ◽  
Karo Tanaka ◽  
Takashi Hori ◽  
Satoko Abe ◽  
Ryuichi Sekizawa ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Morphological Change ◽  
Tyrosine Kinase Inhibitors ◽  
Rous Sarcoma Virus ◽  
Kinase Inhibitors ◽  
Rat Kidney ◽  
Kidney Cells ◽  
Rous Sarcoma ◽  
Sarcoma Virus
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