Exploring the Mechanism of the Peptidyl Transfer Reaction by Chemical Footprinting

2001 ◽  
Vol 66 (0) ◽  
pp. 109-118
Author(s):  
S.A. STROBEL ◽  
G.W. MUTH ◽  
L. CHEN
Keyword(s):  
Transfer Reaction ◽  
Peptidyl Transfer

scholarly journals An Uncharged Amine in the Transition State of the Ribosomal Peptidyl Transfer Reaction

2008 ◽  
Vol 15 (5) ◽  
pp. 493-500 ◽  
Author(s):  
David A. Kingery ◽  
Emmanuel Pfund ◽  
Rebecca M. Voorhees ◽  
Kensuke Okuda ◽  
Ingo Wohlgemuth ◽  
...  
Keyword(s):  
Transition State ◽  
Transfer Reaction ◽  
Peptidyl Transfer

Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

2014 ◽  
Vol 5 (7) ◽  
pp. 2850-2854 ◽  
Author(s):  
O. Vázquez ◽  
O. Seitz
Keyword(s):  
Transfer Reaction ◽  
Peptidyl Transfer ◽  
Cytotoxic Peptide

A RNA triggered chemical peptidyl transfer reaction leads to a cytotoxic peptide conjugate that requires turnover in RNA for bioactivity.

Sulfamides Direct Radical-Mediated Chlorination of Aliphatic C–H Bonds

2019 ◽  
Author(s):  
Melanie Short ◽  
Mina Shehata ◽  
Matthew Sanders ◽  
Jennifer Roizen
Keyword(s):  
Hydrogen Atom ◽  
Transfer Reaction ◽  
Hydrogen Atom Transfer ◽  
Chain Propagation ◽  
Propagation Mechanism ◽  
Atom Transfer ◽  
Radical Chain ◽  
Radical Intermediates ◽  
Transfer Processes ◽  
Unusual Position

Sulfamides guide intermolecular chlorine transfer to gamma-C(sp<sup>3</sup>) centers. This unusual position-selectivity arises because accessed sulfamidyl radical intermediates engage in otherwise rare 1,6-hydrogen-atom transfer processes. The disclosed chlorine-transfer reaction relies on a light-initiated radical chain-propagation mechanism to oxidize C(sp<sup>3</sup>)-H bonds.

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