The proton microscopic optical potential (MOP) based on Skyrme interaction has been achieved by the Green function method in the nuclear matter, and given by the local density approximation (LDA) for finite nuclei. The reaction cross-sections, elastic scattering angular distributions, analyzing powers, and spin-rotation functions are predicted by the obtained proton MOP with Skyrme interaction SkC in the mass range of target nuclei 24[Formula: see text][Formula: see text][Formula: see text]A[Formula: see text][Formula: see text][Formula: see text]209 with incident proton energy below 100[Formula: see text]MeV. These observables are further predicted for some light nuclei and actinide nuclei below 100[Formula: see text]MeV. The prediction is compared with existing experimental data. It is revealed that the obtained proton MOP based on Skyrme interaction SkC can satisfactorily describe the proton–nucleus elastic scattering.