Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor
2016 ◽
Vol 72
(5)
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pp. 692-695
Keyword(s):
In crystal structure of the title compound, C12H21N3O5S3[systematic name: (R)-4-ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide], there exist three kinds of hydrogen-bonding interactions. The sulfonamide group is involved in hydrogen bonding with the secondary amine and the methoxy O atom, resulting in the formation of layers parallel to thebcplane. The layers are linked by an N—H...O hydrogen bond involving a sulfonamide O atom as acceptor and the secondary amine H atom as donor, which gives rise to the formation of a unique bilayer structure. The absolute structure of the molecule in the crystal was determined by resonant scattering [Flack parameter = 0.01 (4)].
2017 ◽
Vol 73
(11)
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pp. 1603-1606
Keyword(s):
2014 ◽
Vol 70
(6)
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pp. o629-o630
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2017 ◽
Vol 73
(7)
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pp. 1070-1072
2006 ◽
Vol 62
(7)
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pp. o2765-o2767
Keyword(s):
2017 ◽
Vol 73
(8)
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pp. 1189-1191
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Keyword(s):
2014 ◽
Vol 70
(11)
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pp. o1183-o1184
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Keyword(s):
2020 ◽
Vol 76
(10)
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pp. 1653-1656
2016 ◽
Vol 72
(5)
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pp. 747-750
Keyword(s):
2018 ◽
Vol 74
(11)
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pp. 1605-1608