Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering

2015 ◽  
Vol 21 (4) ◽  
pp. 386-392 ◽  
Author(s):  
Alida Mazzoli ◽  
C Ferretti ◽  
A Gigante ◽  
E Salvolini ◽  
M Mattioli-Belmonte
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Design Methodology ◽  
Selective Laser Sintering ◽  
Human Mesenchymal Stem Cells ◽  
Laser Sintering ◽  
Porous Scaffolds ◽  
Content Type ◽  
Skeletal Defects

Purpose – The purpose of this study is to show how selective laser sintering (SLS) manufacturing of bioresorbable scaffolds is used for applications in bone tissue engineering. Design/methodology/approach – Polycaprolactone (PCL) scaffolds were computationally designed and then fabricated via SLS for applications in bone and cartilage repair. Findings – Preliminary biocompatibility data were acquired using human mesenchymal stem cells (hMSCs) assuring a satisfactory scaffold colonization by hMSCs. Originality/value – A promising procedure for producing porous scaffolds for the repair of skeletal defects, in tissue engineering applications, was developed.

Selective laser sintering of bioactive composite matrices for bone tissue engineering

2015 ◽  
Vol 6 (2) ◽  
pp. 171-178 ◽  
Author(s):  
E. N. Antonov ◽  
S. M. Barinov ◽  
I. V. Vakhrushev ◽  
V. S. Komlev ◽  
V. K. Popov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Selective Laser Sintering ◽  
Laser Sintering

Fabrication of 13-93 bioactive glass scaffolds for bone tissue engineering using indirect selective laser sintering

2011 ◽  
Vol 3 (2) ◽  
pp. 025004 ◽  
Author(s):  
Krishna C R Kolan ◽  
Ming C Leu ◽  
Gregory E Hilmas ◽  
Roger F Brown ◽  
Mariano Velez
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Selective Laser Sintering ◽  
Laser Sintering

Conceptual design of three-dimensional scaffolds of powder-based materials for bone tissue engineering applications

2015 ◽  
Vol 21 (6) ◽  
pp. 716-724 ◽  
Author(s):  
Ramakrishna Vasireddi ◽  
Bikramjit Basu
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Pore Size ◽  
Bone Tissue ◽  
Bone Repair ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Content Type ◽  
Pore Sizes ◽  
Pore Size Distributions

Purpose – The purpose of this paper is to investigate the possibility to construct tissue-engineered bone repair scaffolds with pore size distributions using rapid prototyping techniques. Design/methodology/approach – The fabrication of porous scaffolds with complex porous architectures represents a major challenge in tissue engineering and the design aspects to mimic complex pore shape as well as spatial distribution of pore sizes of natural hard tissue remain unexplored. In this context, this work aims to evaluate the three-dimensional printing process to study its potential for scaffold fabrication as well as some innovative design of homogeneously porous or gradient porous scaffolds is described and such design has wider implication in the field of bone tissue engineering. Findings – The present work discusses biomedically relevant various design strategies with spatial/radial gradient in pore sizes as well as with different pore sizes and with different pore geometries. Originality/value – One of the important implications of the proposed novel design scheme would be the development of porous bioactive/biodegradable composites with gradient pore size, porosity, composition and with spatially distributed biochemical stimuli so that stem cells loaded into scaffolds would develop into complex tissues such as those at the bone–cartilage interface.

Selective Laser Sintering Process Optimization for Layered Manufacturing of CAPA® 6501 Polycaprolactone Bone Tissue Engineering Scaffolds

2005 ◽  
Vol 128 (2) ◽  
pp. 531-540 ◽  
Author(s):  
Brock Partee ◽  
Scott J. Hollister ◽  
Suman Das
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Layered Manufacturing ◽  
Tissue Engineering Scaffolds ◽  
Porous Architecture ◽  
Manufacturing Methods ◽  
Regenerate Tissue

Tissue engineering combines principles of the life sciences and engineering to replace and repair damaged human tissue. Present tissue engineering methods generally require the use of porous, bioresorbable scaffolds to serve as temporary three-dimensional templates to guide cell attachment, differentiation, proliferation, and subsequent regenerate tissue formation. Such scaffolds are anticipated to play an important role in allowing physicians to simultaneously reconstruct and regenerate damaged human tissues such as bone, cartilage, ligament, and tendon. Recent research strongly suggests that the choice of scaffold material and its internal porous architecture significantly influence regenerate tissue structure and function. However, a lack of versatile biomaterials processing and manufacturing methods capable of meeting the complex geometric and compositional requirements of tissue engineering scaffolds has slowed progress towards fully testing these promising findings. It is widely accepted that layered manufacturing methods such as selective laser sintering (SLS) have the potential to address these requirements. We have investigated SLS as a technique to fabricate tissue engineering scaffolds composed of polycaprolactone (PCL), one of the most widely investigated biocompatible, bioresorbable materials for tissue engineering applications. In this article, we report on our development of optimal SLS processing parameters for CAPA® 6501 PCL powder using systematic factorial design of experiments. Using the optimal parameters, we manufactured test scaffolds with designed porous channels and achieved dimensional accuracy to within 3%–8% of design specifications and densities approximately 94% relative to full density. Finally, using the optimal SLS process parameters, we demonstrated the successful fabrication of bone tissue engineering scaffolds based on actual minipig and human condyle scaffold designs.

Fabrication of porous polyvinyl alcohol scaffold for bone tissue engineering via selective laser sintering

2013 ◽  
Vol 5 (1) ◽  
pp. 015014 ◽  
Author(s):  
Cijun Shuai ◽  
Zhongzheng Mao ◽  
Haibo Lu ◽  
Yi Nie ◽  
Huanlong Hu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polyvinyl Alcohol ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Selective Laser Sintering ◽  
Laser Sintering
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