Prediction of labor for pregnant women using high-resolution mass spectrometry data

2006 ◽  
Author(s):  
Jung Oh ◽  
Animesh Nandi ◽  
Prem Gurnani ◽  
Peter Bryant-Greenwood ◽  
Kevin Rosenblatt ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Pregnant Women ◽  
High Resolution Mass Spectrometry ◽  
Mass Spectrometry Data ◽  
High Resolution Mass ◽  
Resolution Mass

Signal Detection in High-Resolution Mass Spectrometry Data

2008 ◽  
Vol 7 (1) ◽  
pp. 276-285 ◽  
Author(s):  
Dale F. McLerran ◽  
Ziding Feng ◽  
O. John Semmes ◽  
Lisa Cazares ◽  
Timothy W. Randolph
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Signal Detection ◽  
High Resolution Mass Spectrometry ◽  
Mass Spectrometry Data ◽  
High Resolution Mass ◽  
Resolution Mass

The high-resolution mass spectrometry study of the protein composition of amyloid-like urine aggregates associated with preeclampsia

2019 ◽  
Vol 26 (2) ◽  
pp. 158-161 ◽  
Author(s):  
Victoria A Sergeeva ◽  
Natalia V Zakharova ◽  
Anna E Bugrova ◽  
Natalia L Starodubtseva ◽  
Maria I Indeykina ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Pregnant Women ◽  
Congo Red ◽  
Molecular Mechanisms ◽  
High Resolution Mass Spectrometry ◽  
Protein Composition ◽  
High Resolution Mass ◽  
Proteomic Approach ◽  
Resolution Mass

The study of protein misfolding and post-translational processing abnormalities is a promising diagnostic approach for socially significant pathologies associated with the accumulation of abnormal forms of proteins. Recently, it was shown that amyloid-like aggregates can be observed in the urine of pregnant women with preeclampsia, which is the most severe hypertensive complication that can lead to fateful outcomes. The protein composition of urine aggregates may clarify the molecular mechanisms underlying the pathology and has not yet been studied in detail. Using a proteomic approach based on high-resolution mass spectrometry, we studied the protein composition of amyloid-like structures that aggregate in the presence of Congo red azo-dye in the urine of pregnant women with preeclampsia. Fragments of β-sheets of α-1-antitrypsin, complement 3, haptoglobin, ceruloplasmin, and trypstatin were identified as most likely targets for Congo red binding.

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