Experimental study of enhanced therapeutic effect of combining mesenchymal stem cell transplantation with erythropoietin in a myocardial infarction model

2011 ◽  
Author(s):  
Fang Huang ◽  
Zhenya Shen ◽  
Jun Wang ◽  
Michun He ◽  
Xiaomei Teng ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Experimental Study ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Effect ◽  
Mesenchymal Stem Cell Transplantation

Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats

2008 ◽  
Vol 44 (4) ◽  
pp. 662-671 ◽  
Author(s):  
Yukiko Imanishi ◽  
Atsuhiro Saito ◽  
Hiroshi Komoda ◽  
Satoru Kitagawa-Sakakida ◽  
Shigeru Miyagawa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Effect ◽  
Mesenchymal Stem Cell Transplantation

scholarly journals Mesenchymal stem cell transplantation in the reperfused or nonreperfused myocardial infarction scar tissues

2002 ◽  
Vol 39 ◽  
pp. 192
Author(s):  
Tae-Jin Youn ◽  
Bo-Ra Sohn ◽  
Hainan Piao ◽  
Jin-Sook Kwon ◽  
So-Young Choi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation

scholarly journals Optimal time for mesenchymal stem cell transplantation in rats with myocardial infarction

2008 ◽  
Vol 9 (8) ◽  
pp. 630-637 ◽  
Author(s):  
Chen-yang Jiang ◽  
Chun Gui ◽  
Ai-na He ◽  
Xin-yang Hu ◽  
Jie Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Optimal Time ◽  
Mesenchymal Stem Cell Transplantation

The Effect of Age on the Efficacy of Human Mesenchymal Stem Cell Transplantation after a Myocardial Infarction

2010 ◽  
Vol 13 (4) ◽  
pp. 429-438 ◽  
Author(s):  
Ming Fan ◽  
Wei Chen ◽  
Wei Liu ◽  
Guo-Qing Du ◽  
Shu-Lin Jiang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Human Mesenchymal Stem Cell ◽  
Mesenchymal Stem Cell Transplantation ◽  
Effect Of Age

Mesenchymal Stem Cell Transplantation Mitigates Electrophysiological Remodeling in a Rat Model of Myocardial Infarction

2013 ◽  
Vol 24 (7) ◽  
pp. 813-821 ◽  
Author(s):  
PATRICK F.H. LAI ◽  
BRIAN K. PANAMA ◽  
STÉPHANE MASSÉ ◽  
GUANGMING LI ◽  
YAOGUANG ZHANG ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Rat Model ◽  
Mesenchymal Stem Cell Transplantation

scholarly journals Mitochondrial Transfer through Pericardium Contributes to Functional Recovery in Ischemic Cardiomyopathy

2020 ◽  
Author(s):  
Daisuke MORI ◽  
Shigeru MIYAGAWA ◽  
Takuji KAWAMURA ◽  
Daisuke YOSHIOKA ◽  
Hiroki HATA ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Ischemic Cardiomyopathy ◽  
Rat Cardiomyocytes ◽  
Mesenchymal Stem Cell Transplantation ◽  
Mitochondrial Transfer

Abstract Although mesenchymal stem cell transplantation has been efficacious in the treatment of ischemic cardiomyopathy, the underlying mechanisms remain unclear. Herein, we investigated whether mitochondrial transfer could explain the success of cell therapy in ischemic cardiomyopathy. Mitochondrial transfer was examined in co-cultures of human adipose-derived mesenchymal stem cells and rat cardiomyocytes under hypoxic conditions. Functional recovery was monitored in a rat model of myocardial infarction following human adipose-derived mesenchymal stem cell transplantation. In vitro, we observed mitochondrial transfer, which required formation of cell-to-cell contacts and synergistically enhanced energy metabolism. Rat cexhibited mitochondrial transfer three days following human adipose-derived mesenchymal stem cell transplantation to the ischemic heart surface post myocardial infarction. We detected donor mitochondrial DNA in the recipient myocardium concomitant with a significant improvement in cardiac function. In conclusion, mitochondrial transfer is vital for successful cell transplantation therapies and promotes improved treatment outcomes in ischemic cardiomyopathy.

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