A New Computational Tool for the Post Session Analysis of the Prepulse Inhibition Test in Neural Science

This study investigated whether young children with specific expressive language impairment (SELI) learn to combine words according to general positional rules or specific, grammatic relation rules. The language of 20 children with SELI (4 females, 16 males, mean age of 33 months, mean MLU of 1.34) was sampled weekly for 9 weeks. Sixteen of these children also received treatment for two-word combinations (agent+action or possessor+possession). Two different metrics were used to determine the productivity of combinatorial utterances. One metric assessed productivity based on positional consistency alone; another assessed productivity based on positional and semantic consistency. Data were analyzed session-by-session as well as cumulatively. The results suggest that these children learned to combine words according to grammatic relation rules. Results of the session-by-session analysis were less informative than those of the cumulative analysis. For children with SELI ready to make the transition to multiword utterances, these findings support a cumulative method of data collection and a treatment approach that targets specific grammatic relation rules rather than general word combinations.

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SR141716 Ameliorates Ketamine-Induced Prepulse Inhibition Deficits

PsycEXTRA Dataset ◽

10.1037/e413792005-086 ◽

2000 ◽

Author(s):

Janel L. Baer ◽

Sara M. Damrow ◽

Richard A. Deyo ◽

Richard E. Musty

Keyword(s):

Prepulse Inhibition

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Sensorimotor Gating (Prepulse Inhibition of Startle) in Children Exposed to a Single Traumatic Event

PsycEXTRA Dataset ◽

10.1037/e517292011-256 ◽

2009 ◽

Author(s):

Robert Pynoos ◽

Edward Ornitz

Keyword(s):

Prepulse Inhibition ◽

Traumatic Event ◽

Sensorimotor Gating

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Age-Dependent Effects of Modafinil on Acoustic Startle and Prepulse Inhibition

PsycEXTRA Dataset ◽

10.1037/e617962012-197 ◽

2008 ◽

Author(s):

Sandra L. McFadden ◽

Amanda L. Zulas

Keyword(s):

Prepulse Inhibition ◽

Acoustic Startle ◽

Age Dependent

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Hypercoagulability Syndrome Due to Heparin Co-Factor Deficiency

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654844 ◽

1964 ◽

Vol 11 (02) ◽

pp. 485-496 ◽

Cited By ~ 4

Author(s):

B. J Koszewski ◽

H Vahabzadeh

Keyword(s):

Dynamic Process ◽

Blood Clotting ◽

Complete Recovery ◽

Inhibition Test ◽

Factor Deficiency ◽

Heparin Resistance ◽

Fever Therapy ◽

Intensive Course ◽

Plasma Infusions

SummaryA case of hypercoagulability syndrome in a 35 years old male is reported. An abnormal heparin resistance was found which could be defined by means of a heparin clot-inhibition test as a deficiency in heparin co-factor. The required anticoagulant doses of heparin were forty times as high as in cases with intact heparin co-factor. The factor seemed to be used up in the process of coagulation, as plasma, but not serum, was able to correct the deficiency in vitro. Plasma infusions were helpful for four days, but a complete recovery was achieved only after an intensive course of fever therapy.The phenomenon of blood clotting should be regarded as a dynamic process which is facilitated by an array of clot promoting factors and opposed by a system of natural anticoagulants.

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The Lupus Inhibitor: A Study of Its Heterogeneity

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653464 ◽

1981 ◽

Vol 46 (04) ◽

pp. 734-739 ◽

Cited By ~ 10

Author(s):

M C Coots ◽

M A Miller ◽

H I Glueck

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Inhibitory Activity ◽

Inhibition Test ◽

Clotting Factor ◽

Factor Xii ◽

Factor V ◽

Systemic Lupus ◽

Factor Xi ◽

Factor Specificity

SummaryThe plasmas of six patients with prolonged activated partial thromboplastin times were studied in detail. In five of the six, the Russell’s viper venom and prothrombin times were likewise prolonged. Five of the patients had documented systemic lupus erythematosus; one lacked the necessary criteria for this diagnosis. On quantitation, factor XI was decreased in all six; factors X and XII were diminished in five of the six. When tested for inhibitory activity, plasma from each of the patients prolonged the celite eluate inhibition test for factor XII and/or XI inhibition. In the formation of the Xa-V-phospholipid-Ca2+ complex (prothrombinase), factors X and Xa were inhibited to a greater degree than factor V or the phospholipid. Finally, each plasma was isofocused, the inhibitory fractions were identified and the clotting factor specificity of each inhibitory peak was determined.Fractions inhibitory against factors XI and XII isofocused with the IgG in each patient’s plasma. Based on the data presented from these six patients, the “lupus inhibitor” is in fact a heterogeneous collection of inhibitors directed against factors XII, XI and X rather than a homogeneous entity.

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