Quantifying the short-term effects of deep brain stimulation surgery on bradykinesia in Parkinson's disease patients

Author(s):  
Mehdi Delrobaei ◽  
Andrew Parrent ◽  
Mandar Jog ◽  
Stephanie Tran ◽  
Kristina Ognjanovic ◽  
...  





Basal Ganglia ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. 56
Author(s):  
S. Johannes ◽  
A. Keßler ◽  
P. Fricke ◽  
R.-I. Ernestus ◽  
F. Steigerwald ◽  
...  


2014 ◽  
Vol 27 (3) ◽  
pp. 372 ◽  
Author(s):  
Maria Inês Couto ◽  
Ana Monteiro ◽  
Ana Oliveira ◽  
Nuno Lunet ◽  
João Massano

<p><strong>Introduction:</strong> Deep brain stimulation (DBS) is effective in advanced Parkinson’s disease (PD), improving motor symptoms, fluctuations and quality of life. However, adverse psychiatric outcomes have been reported, albeit variably and in an unstandardized fashion. We aimed to summarize the published evidence on the outcomes of anxiety and depressive symptoms in Parkinson’s disease patients following DBS, through systematic review and meta-analysis.<br /><strong>Material and Methods:</strong> PubMed was searched until May 2012 to identify studies assessing anxiety and depressive symptoms in PD patients who underwent bilateral DBS of the subthalamic nucleus (STN) or globus pallidus internus (GPi). Random effects metaanalyses were conducted for groups of at least three studies that were homogeneous regarding the design and the instruments used.<br /><strong>Results:</strong> 63 references were selected; 98.4% provided data on depression, and 38.1% on anxiety assessment scales. Two studies did not discriminate the target; from the remaining 61 references, short-term evaluation was performed in 37 (60.7%), mid-term in 36 (59.0%) and long-term in 5 (8.2%). Data on pre to postop variation was available in 57 (93.4%) reports and 16 (26.2%) presented STNDBS versus different comparison groups: GPi-DBS (n = 4 studies, 25.0%), eligible for surgery (n = 6, 37.5%), and medical treatment (n = 7, 43.8%).<br /><strong>Discussion:</strong> Improvement of depression and anxiety is apparent after DBS, more pronounced in the short-term, an effect that seems to wane in later assessments. Concerning depression, STN-DBS shows superiority against medical treatment, but not when compared to eligible for surgery control groups. The opposite is apparent for anxiety, as results favor medical treatment over STN-DBS, and STNDBS over eligible for surgery control group. Superiority of one target over the other is not evident from the results, but data slightly favors GPi for both outcomes.<br /><strong>Conclusion:</strong> The pattern and course of depressive symptoms and anxiety following DBS in PD is not clear, although both seem to improve in the short-term, especially depression following STN-DBS. Results are highly heterogeneous. Efforts should be carried out to standardize assessment procedures across centers.<br /><strong>Keywords:</strong> Parkinson’s Disease; Deep Brain Stimulation; Anxiety; Depression; Meta-Analysis.</p>



2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Benzi M. Kluger ◽  
Veronica Parra ◽  
Charles Jacobson ◽  
Cynthia W. Garvan ◽  
Ramon L. Rodriguez ◽  
...  

Fatigue is a common and disabling nonmotor symptom seen in Parkinson’s disease (PD). While deep brain stimulation surgery (DBS) improves motor symptoms, it has also been associated with non-motor side effects. To date no study has utilized standardized instruments to evaluate fatigue following DBS surgery. Our objective was to determine the prevalence of fatigue following DBS surgery in PD its impact on quality of life and explore predictive factors. We recruited 44 PD subjects. At least one year following DBS placement, we administered the Fatigue Severity Scale (FSS), the Parkinson’s Disease Questionnaire (PDQ-39), the Beck Depression Inventory, the Beck Anxiety Inventory, the UPDRS, and a neuropsychological battery. Fifty-eight percent of subjects had moderate to severe fatigue. Fatigue was significantly associated with quality of life, depression, and anxiety. Depression preoperatively was the only predictive factor of fatigue. Fatigue is common following DBS surgery and significantly impacts quality of life.



2014 ◽  
Vol 21 (7) ◽  
pp. 1192-1195 ◽  
Author(s):  
Jonathan D. Carlson ◽  
Joshua J. Neumiller ◽  
Lindy D.W. Swain ◽  
Jamie Mark ◽  
Pam McLeod ◽  
...  


2010 ◽  
Vol 31 (4) ◽  
pp. 449-457 ◽  
Author(s):  
Sara Marceglia ◽  
Simona Mrakic-Sposta ◽  
Giorgio Tommasi ◽  
Luigi Bartolomei ◽  
Camillo Foresti ◽  
...  


2010 ◽  
Vol 88 (6) ◽  
pp. 367-373 ◽  
Author(s):  
Frank Schneider ◽  
Martina Reske ◽  
Andreas Finkelmeyer ◽  
Lars Wojtecki ◽  
Lars Timmermann ◽  
...  


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