Analysis of road crashes at the local level is necessary for targeting and implementing effective countermeasures. This chapter presents a contribution to this task. It describes the research carried out in Piedmont, Italy, where an exploratory approach has been used to link road crash data with information about the spatial characteristics of urban settlements. The analytic strategy is developed in three steps. First, fine-grained spatial data for road crashes, land use, traffic counts, and population distribution are linked by GIS methods. Second, a selection of the data is implemented at the municipality level and processed through a cluster analysis to identify territorial accident profiles. Finally, to show their analytic potential, one case study is discussed that considers road segments as main observation units.