FallbackWalk: A Random Walk Based Fallback for Heterogeneous Information Network

Author(s):  
Zhengjun Liu ◽  
Ying Liang ◽  
Xiaojie Xie ◽  
Zisen Wang ◽  
Yongkang Du
Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3668
Author(s):  
Baofang Hu ◽  
Hong Wang ◽  
Zhenmei Yu

Drug side-effects have become a major public health concern as they are the underlying cause of over a million serious injuries and deaths each year. Therefore, it is of critical importance to detect side-effects as early as possible. Existing computational methods mainly utilize the drug chemical profile and the drug biological profile to predict the side-effects of a drug. In the utilized drug biological profile information, they only focus on drug–target interactions and neglect the modes of action of drugs on target proteins. In this paper, we develop a new method for predicting potential side-effects of drugs based on more comprehensive drug information in which the modes of action of drugs on target proteins are integrated. Drug information of multiple types is modeled as a signed heterogeneous information network. We propose a signed heterogeneous information network embedding framework for learning drug embeddings and predicting side-effects of drugs. We use two bias random walk procedures to obtain drug sequences and train a Skip-gram model to learn drug embeddings. We experimentally demonstrate the performance of the proposed method by comparison with state-of-the-art methods. Furthermore, the results of a case study support our hypothesis that modes of action of drugs on target proteins are meaningful in side-effect prediction.


2021 ◽  
Vol 25 (3) ◽  
pp. 711-738
Author(s):  
Phu Pham ◽  
Phuc Do

Link prediction on heterogeneous information network (HIN) is considered as a challenge problem due to the complexity and diversity in types of nodes and links. Currently, there are remained challenges of meta-path-based link prediction in HIN. Previous works of link prediction in HIN via network embedding approach are mainly focused on exploiting features of node rather than existing relations in forms of meta-paths between nodes. In fact, predicting the existence of new links between non-linked nodes is absolutely inconvincible. Moreover, recent HIN-based embedding models also lack of thorough evaluations on the topic similarity between text-based nodes along given meta-paths. To tackle these challenges, in this paper, we proposed a novel approach of topic-driven multiple meta-path-based HIN representation learning framework, namely W-MMP2Vec. Our model leverages the quality of node representations by combining multiple meta-paths as well as calculating the topic similarity weight for each meta-path during the processes of network embedding learning in content-based HINs. To validate our approach, we apply W-TMP2Vec model in solving several link prediction tasks in both content-based and non-content-based HINs (DBLP, IMDB and BlogCatalog). The experimental outputs demonstrate the effectiveness of proposed model which outperforms recent state-of-the-art HIN representation learning models.


Electronics ◽  
2021 ◽  
Vol 10 (14) ◽  
pp. 1671
Author(s):  
Jibing Gong ◽  
Cheng Wang ◽  
Zhiyong Zhao ◽  
Xinghao Zhang

In MOOCs, generally speaking, curriculum designing, course selection, and knowledge concept recommendation are the three major steps that systematically instruct users to learn. This paper focuses on the knowledge concept recommendation in MOOCs, which recommends related topics to users to facilitate their online study. The existing approaches only consider the historical behaviors of users, but ignore various kinds of auxiliary information, which are also critical for user embedding. In addition, traditional recommendation models only consider the immediate user response to the recommended items, and do not explicitly consider the long-term interests of users. To deal with the above issues, this paper proposes AGMKRec, a novel reinforced concept recommendation model with a heterogeneous information network. We first clarify the concept recommendation in MOOCs as a reinforcement learning problem to offer a personalized and dynamic knowledge concept label list to users. To consider more auxiliary information of users, we construct a heterogeneous information network among users, courses, and concepts, and use a meta-path-based method which can automatically identify useful meta-paths and multi-hop connections to learn a new graph structure for learning effective node representations on a graph. Comprehensive experiments and analyses on a real-world dataset collected from XuetangX show that our proposed model outperforms some state-of-the-art methods.


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