Data acquisition is the basic means of access to information; it is an important pillar of the information science, a comprehensive application technology associated with the sensor, signal measuring and processing, computer technology as the foundation. USB has the characteristics of easy to use, high speed and supporting to cut in or pull out on-line, it becomes a trend in data acquisition technology. To introduce the hardware and software design, selecting DSP for microprocessor control chip and Philip Corporations ISP1582 for USB receiver/transfer control chip. In this paper, the segmented band-pass filtering is adopted to filter the collected data, the problems in system debugging are analyzed and summarized, and the measures for improvement are finally put forward. Thus, combining USB and DSP is an effective solution to data acquisition with high speed as well as processing and transmitting.