4D Simulator Using Evolving Cellular Automata for Computer Aided Macrophage Behavior Analysis

Author(s):  
Yuichi Ishibashi ◽  
Manabu Nii ◽  
Daiki Komori ◽  
Takuya Iwamoto ◽  
Tomoharu Nakashima ◽  
...  
1998 ◽  
Vol 24 (2) ◽  
pp. 154-156 ◽  
Author(s):  
S. G. Psakh’e ◽  
D. D. Moiseenko ◽  
A. I. Dmitriev ◽  
E. V. Shil’ko ◽  
S. Yu. Korostelev ◽  
...  

Author(s):  
Nisha V M ◽  
L Jeganathan

Computer aided diagnosis (CAD) is an advancing technology in medical imaging. CAD acts as an additional computing power for doctors to interpret the medical images which leads to a more accurate diagnosis of the disease.CAD system increases the chances of detection of brain lesions by assisting the physicians in decreasing the observational oversight in the early stage of diseases.This paper focuses on the development of a cellular automata based model to find the anomaly prone areas in human brains.Because of the bilateral symmetric nature of human brain, a symmetry based cellular automata model is proposed.An algorithm is designed based on the proposed model to detect the anomaly prone areas in brain images. The proposed model can be a standalone model or it can be incorporated to a sophisticated computer aided diagnosis system. By incorporating asymmetry information into a computer aided diagnosis system, enhances its performance in identifying the anomalies exists in bilaterally symmetrical brain images.


Author(s):  
Mark Ellisman ◽  
Maryann Martone ◽  
Gabriel Soto ◽  
Eleizer Masliah ◽  
David Hessler ◽  
...  

Structurally-oriented biologists examine cells, tissues, organelles and macromolecules in order to gain insight into cellular and molecular physiology by relating structure to function. The understanding of these structures can be greatly enhanced by the use of techniques for the visualization and quantitative analysis of three-dimensional structure. Three projects from current research activities will be presented in order to illustrate both the present capabilities of computer aided techniques as well as their limitations and future possibilities.The first project concerns the three-dimensional reconstruction of the neuritic plaques found in the brains of patients with Alzheimer's disease. We have developed a software package “Synu” for investigation of 3D data sets which has been used in conjunction with laser confocal light microscopy to study the structure of the neuritic plaque. Tissue sections of autopsy samples from patients with Alzheimer's disease were double-labeled for tau, a cytoskeletal marker for abnormal neurites, and synaptophysin, a marker of presynaptic terminals.


Author(s):  
Greg V. Martin ◽  
Ann L. Hubbard

The microtubule (MT) cytoskeleton is necessary for many of the polarized functions of hepatocytes. Among the functions dependent on the MT-based cytoskeleton are polarized secretion of proteins, delivery of endocytosed material to lysosomes, and transcytosis of integral plasma membrane (PM) proteins. Although microtubules have been shown to be crucial to the establishment and maintenance of functional and structural polarization in the hepatocyte, little is known about the architecture of the hepatocyte MT cytoskeleton in vivo, particularly with regard to its relationship to PM domains and membranous organelles. Using an in situ extraction technique that preserves both microtubules and cellular membranes, we have developed a protocol for immunofluorescent co-localization of cytoskeletal elements and integral membrane proteins within 20 µm cryosections of fixed rat liver. Computer-aided 3D reconstruction of multi-spectral confocal microscope images was used to visualize the spatial relationships among the MT cytoskeleton, PM domains and intracellular organelles.


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