The supply chain management theory is advanced by a joint investigation of the mediating role of (a) supply chain responsiveness (SCR) (e.g., operation, logistic and supplier network responsiveness) in linking supply chain management practices (SCMP) with product development (PD) and (b) the moderating role of organization structure (OS) and research and development (R&D) in influencing the mediation. Using K. J. Preacher, D. D. Rucker and A. F. Hayes’s [Addressing moderated mediation hypotheses: Theory, methods, and prescriptions, Multivariate Behavioral Research 42(1) (2007) 185–227] moderated mediation framework, the authors tested the model with survey data from 210 White-collars of national and multinational fast moving consumer goods companies operating in Pakistan. Results showed that SCR mediated the relationship between supply chain management practices with product development. Moderated mediation analyses further revealed that organization structure moderated the mediation for supply chain management practices with supply chain responsiveness, whereas research and development moderated the mediation for supply chain responsiveness and product development. Additionally, theoretical and practical implications are discussed.