Andrés-Felipe Villamizar-Mogotocoro
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Andrés-Felipe León-Rojas
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Juan-Manuel Urbina-González
The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as γ- butenolides or appropriately as Δα,β-butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, Δα,β-butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the Δα,β-butenolide ring formation, along with selected examples of compounds with relevant biological activities of these promising pharmaceutical entities is presented.
Multicellular Ring Formation in Dictyostelium discoieum