Bias voltages at microelectrodes change neural interface properties in vivo

2005 ◽  
Author(s):  
M.D. Johnson ◽  
K.J. Otto ◽  
J.C. Williams ◽  
D.R. Kipke
Keyword(s):  
Neural Interface ◽  
Interface Properties

Insulating Biomaterials Research for Implantable Microelectronic Devices

2003 ◽  
Vol 773 ◽  
Author(s):  
David J. Edell
Keyword(s):  
Chemical Resistance ◽  
Chemical Vapor ◽  
Film Coating ◽  
Neural Interface ◽  
Thin Film Coating ◽  
Accelerated Degradation ◽  
Microelectronic Devices ◽  
Chemical Vapor Deposited

AbstractDevelopments in the field of BioMEMS share many of the same issues encountered in the development of neural interface technology that has been underway for many decades. In addition to issues of function, other issues such as biocompatibility and bioresistance have also presented great challenges. The focus of this paper is on the development and testing of electrically insulating biomaterials for micro-devices that can be implanted in biological systems. A variety of accelerated degradation and accelerated detection of degradation techniques have been developed and are used to screen candidate materials. Direct tests of mechanical properties, adhesion, and chemical resistance are used for further assessment. Promising materials indicate what chemistry might be suitable for development of a Chemical Vapor Deposited (CVD) thin film coating. CVD coatings are under development that may be useful for insulation of very small, micromachined elements of an implantable device while only increasing the size of the device by a few micrometers. Materials passing in-vitro testing are then considered for in-vivo testing. Novel instrumentation for testing devices in-vivo has been developed.

scholarly journals Chitosan‐Based, Biocompatible, Solution Processable Films for In Vivo Localization of Neural Interface Devices

2019 ◽  
Vol 5 (3) ◽  
pp. 1900663 ◽  
Author(s):  
Onni J. Rauhala ◽  
Soledad Dominguez ◽  
George D. Spyropoulos ◽  
Jose Javier Ferrero ◽  
Talia R. Boyers ◽  
...  
Keyword(s):  
Neural Interface ◽  
Solution Processable ◽  
Interface Devices

A Study on the Mechanical Properties of Acellular Dermal Matrices and Their Interface Properties After Implantation in an Acute Abdominal Wall Defect in a Primate

2013 ◽  
Author(s):  
P. G. De Deyne ◽  
T. Diab ◽  
M. Sandor
Keyword(s):  
Mechanical Properties ◽  
Abdominal Wall Defect ◽  
Interface Strength ◽  
Interface Properties ◽  
Wall Defect ◽  
Acellular Tissue ◽  
Dermal Matrices ◽  
Tissue Matrix ◽  
Acellular Dermal

Within Regenerative Medicine, non-cell-based approaches such as biologically-derived materials have been commercially successful and represent an important proportion of medically-used biomaterials1. Several acellular matrices are commercially available, to be used as a reinforcement of soft tissue where weakness exists. The goal of this study was to determine whether out-of-package mechanical properties of an acellular tissue matrix was predictive of its in vivo interface strength and whether the in vivo interface strength was associated with a particular histological response. We chose to test three porcine dermis-derived acellular matrices and one bovine pericardium derived matrix.

scholarly journals A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yoo Na Kang ◽  
Namsun Chou ◽  
Jae-Won Jang ◽  
Han Kyoung Choe ◽  
Sohee Kim
Keyword(s):  
Microelectrode Array ◽  
Neurological Diseases ◽  
Three Dimensional ◽  
Critical Issue ◽  
Neural Interface ◽  
Neural Interfaces ◽  
Dimensional Structure ◽  
Microfluidic Channels ◽  
Before And After

AbstractThe demand for multifunctional neural interfaces has grown due to the need to provide a better understanding of biological mechanisms related to neurological diseases and neural networks. Direct intracerebral drug injection using microfluidic neural interfaces is an effective way to deliver drugs to the brain, and it expands the utility of drugs by bypassing the blood–brain barrier (BBB). In addition, uses of implantable neural interfacing devices have been challenging due to inevitable acute and chronic tissue responses around the electrodes, pointing to a critical issue still to be overcome. Although neural interfaces comprised of a collection of microneedles in an array have been used for various applications, it has been challenging to integrate microfluidic channels with them due to their characteristic three-dimensional structures, which differ from two-dimensionally fabricated shank-type neural probes. Here we present a method to provide such three-dimensional needle-type arrays with chemical delivery functionality. We fabricated a microfluidic interconnection cable (µFIC) and integrated it with a flexible penetrating microelectrode array (FPMA) that has a 3-dimensional structure comprised of silicon microneedle electrodes supported by a flexible array base. We successfully demonstrated chemical delivery through the developed device by recording neural signals acutely from in vivo brains before and after KCl injection. This suggests the potential of the developed microfluidic neural interface to contribute to neuroscience research by providing simultaneous signal recording and chemical delivery capabilities.

scholarly journals Preliminary Minimum Reporting Requirements for Reporting In-Vivo Neural Interface Research: I. Implantable Neural Interfaces

2020 ◽  
Author(s):  
Calvin D. Eiber ◽  
Jean Delbeke ◽  
Jorge Cardoso ◽  
Martijn de Neeling ◽  
Sam E. John ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Reporting Guidelines ◽  
Neural Interface ◽  
Reporting Standard ◽  
Full Spectrum ◽  
Open Collaboration ◽  
Reporting Requirements ◽  
Number Of Publications ◽  
Design Freedom

AbstractThe pace of research and development in neuroscience, neurotechnology, and neurorehabilitation is rapidly accelerating, with the number of publications doubling every 4.2 years. Maintaining this progress requires technological standards and scientific reporting guidelines to provide frameworks for communication and interoperability. The present lack of such standards for neurotechnologies limits the transparency, reproducibility, and meta-analysis of this growing body of research, posing an ongoing barrier to research, clinical, and commercial objectives.Continued neurotechnological innovation requires the development of some minimal standards to promote integration between this broad spectrum of technologies and therapies. To preserve design freedom and accelerate the translation of research into safe and effective technologies with maximal user benefit, such standards must be collaboratively co-developed by a full spectrum of neuroscience and neurotechnology stakeholders. This paper summarizes the preliminary recommendations of IEEE Working Group P2794, developing a Reporting Standard for in-vivo Neural Interface Research (RSNIR).Impact StatementThis work provides a preliminary set of reporting guidelines for implantable neural interface research, developed by IEEE WG P2794 in open collaboration between a range of stakeholders to accelerate the research, development, and integration of innovative neurotechnologies.

Transparent neural interface for in vivo interrogation of human organoids

2021 ◽  
Author(s):  
Madison Wilson ◽  
Martin Thunemann ◽  
Francesca Puppo ◽  
Abed Mansour ◽  
Alysson R. Muotri ◽  
...  
Keyword(s):  
Neural Interface
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