The hippocampus has been firmly established as playing a crucial role in flexible navigation. Recent evidence suggests that dorsal striatum may also play an important role in such goal-directed behaviour in both rodents and humans. Across recent studies, activity in the caudate nucleus has been linked to forward planning and adaptation to changes in the environment. In particular, several human neuroimaging studies have found the caudate nucleus tracks information traditionally associated with that by the hippocampus. In this brief review, we examine this evidence and argue the dorsal striatum encodes the transition structure of the environment during flexible, goal-directed behaviour. We highlight that future research should explore the following: (1) Investigate neural responses during spatial navigation via a biophysically plausible framework explained by reinforcement learning models and (2) Observe the interaction between cortical areas and both the dorsal striatum and hippocampus during flexible navigation.
Striatal and hippocampal contributions to flexible navigation in rats and humans