This paper presents a predictive control strategy for seismic protection of a benchmark cable-stayed bridge with consideration of multiple-support excitations. In this active control strategy, a multi-step predictive model is built to estimate the seismic dynamics of cable-stayed bridge and the effects of some complicated factors such as time-varying, model mismatching, disturbances and uncertainty of controlled system, are taken into account by the prediction error feedback in the multi-step predictive model. The prediction error is that the actual system output is compared to the model prediction at each time step. Numerical simulation is carried out for analyzing the seismic responses of the controlled cable-stayed bridge and the results show that the developed predictive control strategy can reduce the seismic response of benchmark cable-stayed bridge efficiently.