Web 2.0 has been adopted by many as the best way for forming a collaborative framework e.g., sharing resources, experiences, information, knowledge and feedback. A collaborative framework for application to e-health is necessary to provide patients with the awareness that assists in improving their health. Moreover, collaborative framework can be used by physician to exchange experiences and discuss challenge cases. However, the use of Web 2.0 with healthcare applications is not simple as the use of Web 20 with other enterprise applications according to the privacy of healthcare applications, which requires high quality and security of data, availability of resources, maintainability of services, system security, and Quality of Services (QoS). To offer the required requirements, grid computing is proposed here. Grid computing supporting enterprise applications through offering massive resources through resources collaborative framework that is offering power computing, storage devices, and services. The use of grid computing by Web 2.0 requires robust model that is able to deploy, discover, invoke, and integrate resources in open standard format. Therefore, Service Oriented Architecture (SOA) is adopted as a model for managing the mixing between Web 2.0 and grid computing technologies. SOA for Web 2.0 and Grid Computing (SOAW2G) are used throughout this work to offer a fabric for e-health applications.