Noncollocated passive control of a flexible link manipulator

Author(s):  
C. Trautman ◽  
D. Wang
1992 ◽  
Vol 11 (6) ◽  
pp. 572-578 ◽  
Author(s):  
David Wang ◽  
M. Vidyasagar

1989 ◽  
Author(s):  
John D. Charlton ◽  
James J. Brickley

Author(s):  
Guilherme Silva Prado ◽  
Heinsten Frederich Leal dos Santos

Author(s):  
Y Madhusudan Rao ◽  
Gayatri P ◽  
Ajitha M ◽  
P. Pavan Kumar ◽  
Kiran kumar

Present investigation comprises the study of ex-vivo skin flux and in-vivo pharmacokinetics of Thiocolchicoside (THC) from transdermal films. The films were fabricated by solvent casting technique employing combination of hydrophilic and hydrophobic polymers. A flux of 18.08 µg/cm2h and 13.37µg/cm2h was achieved for optimized formulations containing 1, 8-cineole and oleic acid respectively as permeation enhancers. The observed flux values were higher when compared to passive control (8.66 µg/cm2h). Highest skin permeation was observed when 1,8-cineole was used as chemical permeation enhancer and it considerably (2-2.5 fold) improved the THC transport across the rat skin. In vivo studies were performed in rabbits and samples were analysed by LC-MS-MS. The mean area under the curve (AUC) values of transdermal film showed about 2.35 times statistically significant (p<0.05) improvement in bioavailability when compared with the oral administration of THC solution. The developed transdermal therapeutic systems using chemical permeation enhancers were suitable for drugs like THC in effective management of muscular pain.    


2014 ◽  
Vol 757 ◽  
pp. 908-942 ◽  
Author(s):  
K. Matsuura ◽  
M. Nakano

AbstractThis study investigates the suppression of the sound produced when a jet, issued from a circular nozzle or hole in a plate, goes through a similar hole in a second plate. The sound, known as a hole tone, is encountered in many practical engineering situations. The mean velocity of the air jet $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}u_0$ was $6\text {--}12\ \mathrm{m}\ {\mathrm{s}}^{-1}$. The nozzle and the end plate hole both had a diameter of 51 mm, and the impingement length $L_{im}$ between the nozzle and the end plate was 50–90 mm. We propose a novel passive control method of suppressing the tone with an axisymmetric obstacle on the end plate. We find that the effect of the obstacle is well described by the combination ($W/L_{im}$, $h$) where $W$ is the distance from the edge of the end plate hole to the inner wall of the obstacle, and $h$ is the obstacle height. The tone is suppressed when backflows from the obstacle affect the jet shear layers near the nozzle exit. We do a direct sound computation for a typical case where the tone is successfully suppressed. Axisymmetric uniformity observed in the uncontrolled case is broken almost completely in the controlled case. The destruction is maintained by the process in which three-dimensional vortices in the jet shear layers convect downstream, interact with the obstacle and recursively disturb the jet flow from the nozzle exit. While regions near the edge of the end plate hole are responsible for producing the sound in the controlled case as well as in the uncontrolled case, acoustic power in the controlled case is much lower than in the uncontrolled case because of the disorganized state.


Sign in / Sign up

Export Citation Format

Share Document