GREEN: A Global Optimization Scheme for Transportation Efficiency by Mining Taxi Mobility

Author(s):  
Huigui Rong ◽  
Shengxu Huo ◽  
Qun Zhang ◽  
Hui Zheng ◽  
Chang Yang
2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Ali Jalali ◽  
Allan F. Simpao ◽  
Jorge A. Gálvez ◽  
Robert A. Berg ◽  
Vinay M. Nadkarni ◽  
...  

Introduction. The quality of cardiopulmonary resuscitation (CPR) has been shown to impact patient outcomes. However, post-CPR morbidity and mortality remain high, and CPR optimization is an area of active research. One approach to optimizing CPR involves establishing reliable CPR performance measures and then modifying CPR parameters, such as compressions and ventilator breaths, to enhance these measures. We aimed to define a reliable CPR performance measure, optimize the CPR performance based on the defined measure and design a dynamically optimized scheme that varies CPR parameters to optimize CPR performance. Materials and Methods. We selected total blood gas delivery (systemic oxygen delivery and carbon dioxide delivery to the lungs) as an objective function for maximization. CPR parameters were divided into three categories: rescuer dependent, patient dependent, and constant parameters. Two optimization schemes were developed using simulated annealing method: a global optimization scheme and a sequential optimization scheme. Results and Discussion. Variations of CPR parameters over CPR sequences (cycles) were analyzed. Across all patient groups, the sequential optimization scheme resulted in significant enhancement in the effectiveness of the CPR procedure when compared to the global optimization scheme. Conclusions. Our study illustrates the potential benefit of considering dynamic changes in rescuer-dependent parameters during CPR in order to improve performance. The advantage of the sequential optimization technique stemmed from its dynamically adapting effect. Our CPR optimization findings suggest that as CPR progresses, the compression to ventilation ratio should decrease, and the sequential optimization technique can potentially improve CPR performance. Validation in vivo is needed before implementing these changes in actual practice.


2008 ◽  
Vol 07 (02) ◽  
pp. 177-187 ◽  
Author(s):  
YUGUANG MU ◽  
YE YANG ◽  
WEIXIN XU

A global optimization scheme which utilizes the framework of replica-exchange simulation and replaces the system exchange probability for jumping between different temperature replicas with the kernel exchange probability is brought out. The kernel exchange probability is calculated by taking into account the kernel part interaction, including protein–protein interactions only, with protein–solvent and solvent–solvent interactions approximated by a continuum solvation model. All the configurations are sampled with potential energies explicitly considering water molecules during the simulation while the energies obtained from continuum solvation model play as a scoring function to rank the conformation during the exchange process. It is shown that this method gives nearly identical total potential energy distribution in the solvated alanine dipeptide system compared with the results of the standard replica-exchange simulation in which much more number of replicas has to be employed. This optimization method is highly demonstrated in successfully folding a β-hairpin peptide, C-terminus (residue 41-56) of protein G, from the extended structure to native conformation.


Geophysics ◽  
2012 ◽  
Vol 77 (4) ◽  
pp. T125-T135 ◽  
Author(s):  
Jin-Hai Zhang ◽  
Zhen-Xing Yao

Implicit finite-difference (FD) migration is unconditionally stable and is popular in handling strong velocity variations, but its extension to strongly transversely anisotropic media with vertical symmetric axis media is difficult. Traditional local optimizations generate the optimized coefficients for each pair of Thomsen anisotropy parameters independently, which can degrade results substantially for large anisotropy variations and lead to a huge table. We developed an implicit FD method using the analytic Taylor-series expansion and used a global optimization scheme to improve its accuracy for wide phase angles. We first extended the number of the constant coefficients; then we relaxed the coefficient of the time-delay extrapolation term by tuning a small factor such that error is less than 0.1%. Finally, we optimized the constant coefficients using a simulated annealing algorithm by constraining that all the error functions on a fine grid of the whole anisotropic region did not exceed 0.5% simultaneously. The extended number of the constant coefficients and the relaxed coefficient greatly enhanced the flexibility of matching the dispersion relation and significantly improved the ability of handling strong anisotropy over a much wider range. Compared with traditional local optimization, our scheme does not need any table and table lookup. For each order of the FD method, only one group of optimized coefficients is enough to handle strong variations in velocity and anisotropy. More importantly, our global optimization scheme guarantees the accuracy for various possible ranges of anisotropy parameters, no matter how strong the anisotropy is. For the globally optimized second-order FD method, the accurate phase angle is up to 58°, and the increase is about 18°–22°. For the globally optimized fourth-order FD method, the accurate phase angle is up to 77°, and the increase is about 22°–27°.


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