scholarly journals Convective-Dispersion Modeling in 3D Contrast-Ultrasound Imaging for the Localization of Prostate Cancer

2018 ◽  
Vol 37 (12) ◽  
pp. 2593-2602 ◽  
Author(s):  
R. R. Wildeboer ◽  
R. J. G. Van Sloun ◽  
S. G. Schalk ◽  
C. K. Mannaerts ◽  
J. C. Van Der Linden ◽  
...  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu Wang ◽  
Al Christopher De Leon ◽  
Reshani Perera ◽  
Eric Abenojar ◽  
Ramamurthy Gopalakrishnan ◽  
...  

AbstractUltrasound imaging is routinely used to guide prostate biopsies, yet delineation of tumors within the prostate gland is extremely challenging, even with microbubble (MB) contrast. A more effective ultrasound protocol is needed that can effectively localize malignancies for targeted biopsy or aid in patient selection and treatment planning for organ-sparing focal therapy. This study focused on evaluating the application of a novel nanobubble ultrasound contrast agent targeted to the prostate specific membrane antigen (PSMA-targeted NBs) in ultrasound imaging of prostate cancer (PCa) in vivo using a clinically relevant orthotopic tumor model in nude mice. Our results demonstrated that PSMA-targeted NBs had increased extravasation and retention in PSMA-expressing orthotopic mouse tumors. These processes are reflected in significantly different time intensity curve (TIC) and several kinetic parameters for targeted versus non-targeted NBs or LUMASON MBs. These, may in turn, lead to improved image-based detection and diagnosis of PCa in the future.


2021 ◽  
Author(s):  
Derek Y. Chan ◽  
D. Cody Morris ◽  
Theresa Lye ◽  
Thomas J. Polascik ◽  
Mark L. Palmeri ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Saskia M. Camps ◽  
Davide Fontanarosa ◽  
Peter H. N. de With ◽  
Frank Verhaegen ◽  
Ben G. L. Vanneste

External beam radiotherapy (EBRT) is one of the curative treatment options for prostate cancer patients. The aim of this treatment option is to irradiate tumor tissue, while sparing normal tissue as much as possible. Frequent imaging during the course of the treatment (image guided radiotherapy) allows for determination of the location and shape of the prostate (target) and of the organs at risk. This information is used to increase accuracy in radiation dose delivery resulting in better tumor control and lower toxicity. Ultrasound imaging is harmless for the patient, it is cost-effective, and it allows for real-time volumetric organ tracking. For these reasons, it is an ideal technique for image guidance during EBRT workflows. Review papers have been published in which the use of ultrasound imaging in EBRT workflows for different cancer sites (prostate, breast, etc.) was extensively covered. This new review paper aims at providing the readers with an update on the current status for prostate cancer ultrasound guided EBRT treatments.


2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Mohamed Eltemamy ◽  
Michael Leapman ◽  
Janet Cowan ◽  
Katsuto Shinohara ◽  
Antonio Westphalen ◽  
...  

2015 ◽  
Vol 34 (6) ◽  
pp. 1115-1122 ◽  
Author(s):  
Brendon W. Smith ◽  
Douglas G. Simpson ◽  
Sandhya Sarwate ◽  
Rita J. Miller ◽  
John W. Erdman ◽  
...  

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