Bioelectric signals are distorted by unwanted electric noise interference. This paper focuses on techniques that can be applied to surface electromyographic systems design to improve the signal-to-noise ratio. Three case studies are presented in this manuscript: Effects of the front-end instrumentation amplifier gain, use of dc-dc converters for single-supply operation, and dedicated hardware for 60 Hz power line noise rejection. Results show that the quality of the signal is highly improved when the suggested techniques are applied.