Based on stochastic time-delay system stability criterion and a homogeneous domination approach, the output-feedback stabilization problem for a class of more general stochastic upper-triangular systems with state and input time-delays has been solved in this paper. Firstly, the initial system is changed into an equivalent one with a designed scalar by introducing a set of coordinate transformations. After that, by designing an implementable homogeneous reduced-order observer, and tactfully selecting a suitable Lyapunov–Krasoviskii functional and a low gain scale, a delay-independent output-feedback controller is explicitly constructed. Finally, the globally asymptotically stability in probability of the closed-loop system is ensured by rigorous proof. The simulation results demonstrate the efficiency of the proposed design scheme.