Choosing data sets that optimize the determinant of the Fisher information matrix

2002 ◽  
Author(s):  
W.L. Poston ◽  
J.L. Solka
Keyword(s):  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Data Sets

scholarly journals Generalized Truncation Positive Normal Distribution

Symmetry ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1361
Author(s):  
Héctor J. Gómez ◽  
Diego I. Gallardo ◽  
Osvaldo Venegas
Keyword(s):  
Maximum Likelihood ◽  
Normal Distribution ◽  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Maximum Likelihood Estimators ◽  
Real Data ◽  
Data Sets ◽  
New Model ◽  
Positive Support

In this article we study the properties, inference, and statistical applications to a parametric generalization of the truncation positive normal distribution, introducing a new parameter so as to increase the flexibility of the new model. For certain combinations of parameters, the model includes both symmetric and asymmetric shapes. We study the model’s basic properties, maximum likelihood estimators and Fisher information matrix. Finally, we apply it to two real data sets to show the model’s good performance compared to other models with positive support: the first, related to the height of the drum of the roller and the second, related to daily cholesterol consumption.

scholarly journals Optimal design for population pk/pd models

2012 ◽  
Vol 51 (1) ◽  
pp. 115-130
Author(s):  
Sergei Leonov ◽  
Alexander Aliev
Keyword(s):  
Optimal Design ◽  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Optimal Sampling ◽  
Design Algorithm ◽  
Sampling Schemes ◽  
Population Pk ◽  
Different Types

ABSTRACT We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

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