Nitric oxide modulates μ‐opioid receptor function in vitro

2019 ◽  
Vol 46 (7) ◽  
pp. 676-685 ◽  
Author(s):  
Lillian Huang ◽  
Bruce D. Wyse ◽  
Craig M. Williams ◽  
Maree T. Smith
Keyword(s):  
Nitric Oxide ◽  
Opioid Receptor ◽  
Receptor Function ◽  
Μ Opioid Receptor

scholarly journals Dexamethasone-induced selective inhibition of the central μ opioid receptor: functional in vivo and in vitro evidence in rodents

1994 ◽  
Vol 113 (4) ◽  
pp. 1416-1422 ◽  
Author(s):  
S. Pieretti ◽  
A. Giannuario ◽  
M.R. Domenici ◽  
S. Sagratella ◽  
A. Capasso ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Selective Inhibition ◽  
Μ Opioid Receptor

scholarly journals In vivo and in vitro inhibition of human liver cancer progress by downregulation of the μ-opioid receptor and relevant mechanisms

2013 ◽  
Vol 30 (4) ◽  
pp. 1731-1738 ◽  
Author(s):  
JIN LU ◽  
ZEFENG LIU ◽  
LINGLING ZHAO ◽  
HUIMIN TIAN ◽  
XIUHUA LIU ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Opioid Receptor ◽  
Human Liver ◽  
Human Liver Cancer ◽  
Μ Opioid Receptor ◽  
In Vitro Inhibition

Emerging pharmacologic mechanisms of buprenorphine to explain experience of analgesia versus adverse effects

2021 ◽  
Vol 17 (7) ◽  
pp. 21-31
Author(s):  
Jeffrey Bettinger, PharmD ◽  
Himayapsill Batista Quevedo, PharmD ◽  
Jacqueline Cleary, PharmD, BCACP
Keyword(s):  
Adverse Effects ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Partial Agonist ◽  
Clinical Trial Data ◽  
Receptor Activation ◽  
Cellular Mechanisms ◽  
Μ Opioid Receptor ◽  
Addictive Potential

Buprenorphine’s unique pharmacologic mechanisms of action lend itself to a higher level of complexity than its typical characterization as a partial agonist at μ-opioid receptors. It is well-documented that its additional activity at Δ- and κ-opioid receptors, and opioid receptor ligand 1 may be associated with varying degrees of analgesia and usual opioid-related adverse effects. However, novel downstream molecular and cellular mechanisms from μ-opioid receptor activation contain potential new insights into its overall unique effects. These include buprenorphine’s peculiar ability to induce analgesia at escalating doses, while exhibiting a plateaued effect on respiratory depression, euphoria, gastrointestinal (GI) motility, depression, anxiety, and addictive potential. Thus, this review aims to discuss several of these emerging mechanisms to gain a better understanding of these curious actions, as well as support much of this in vitro evidence with various human clinical trial data to further support buprenorphine’s place on the analgesic ladder.

μ-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic Mechanism In Vitro and in the Mammalian Brain

1998 ◽  
Vol 53 (3) ◽  
pp. 377-384 ◽  
Author(s):  
Duane E. Keith ◽  
Benito Anton ◽  
Stephen R. Murray ◽  
Paulette A. Zaki ◽  
Peter C. Chu ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Internalization ◽  
Mammalian Brain ◽  
Differential Effects ◽  
Opiate Drugs ◽  
Μ Opioid Receptor
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