The impact of metformin on hypothalamic‐pituitary‐thyroid axis activity in postmenopausal women with untreated non‐autoimmune subclinical hypothyroidism

2021 ◽  
Author(s):  
Robert Krysiak ◽  
Karolina Kowalcze ◽  
Bogusław Okopień
Keyword(s):  
Postmenopausal Women ◽  
Subclinical Hypothyroidism ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
The Impact

Mild hyperthyroidism with inappropriate secretion of TSH in postmenopausal women

1986 ◽  
Vol 111 (2) ◽  
pp. 204-208 ◽  
Author(s):  
N. Custro ◽  
V. Scafidi
Keyword(s):  
Thyroid Hormones ◽  
Postmenopausal Women ◽  
Present Report ◽  
Serum Levels ◽  
Suppressive Effect ◽  
Pituitary Thyroid Axis ◽  
Tsh Secretion ◽  
Thyroid Axis ◽  
Suppression Test ◽  
Inappropriate Tsh Secretion

Abstract. In a previous study on the function of the hypothalamus - pituitary - thyroid axis, about 10% of postmenopausal women with the climacteric syndrome were found to have borderline high values of T3 and T4 and signs of pituitary decreased sensitivity to the suppressive effect of increased thyroid hormones. The present report concerns 5 women in the first phase of their menopause who showed a mild hyperthyroidism under basal conditions and after suppression test with liothyronine. Each patient had borderline increased levels of serum total and free T4 and T3 and a marked TSH responsiveness to exogenous TRH. After liothyronine, the serum levels of T4, FT4, TSH and the responsiveness to TRH-test clearly decreased. These data suggest an inappropriate TSH secretion with a decreased pituitary sentitivity to thyroid hormones. These cases could represent a modification of the hypothalamus-pituitary-thyroid axis associated with that of the gonadal axis, secondary to the absence of rapid adaptation of neurotransmitters.

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