Sodium Lauryl Sulphate for Irritant Patch Testing- A Dose-Response Study Using Bioengineering Methods for Determination of Skin Irritation

Abstract Interlaboratory variability in certain acute, toxicological procedures was discussed. Three collaborative studies have been performed. One study concerned a determination of acute peroral toxicity and 2 collaborative studies have involved eye and/or skin irritation. All have indicated that, while the majority of the laboratories produced relatively consistent results, some were definitely outliers and others were quite variable. Recommendations were made to counteract and correct this interlaboratory variability; it was suggested that these be accomplished before standardization of techniques be promulgated. A brief discussion was presented on the faulty conclusions that can result from improperly planned and executed repeated-dose toxicological studies. Furthermore, the estimation of risk at the low-response end of a doseresponse curve was discussed. The relative variability of the measurement of the slope of such a curve was compared to the variability of the measurement of the midpoint. The danger of extrapolation of animal dose-response results, using a constant slope, was deprecated.

Download Full-text

Determination of clinical and luteolytic effectiveness of a prostaglandin analog in mares by a dose response study

Theriogenology ◽

10.1016/0093-691x(81)90077-7 ◽

1981 ◽

Vol 16 (4) ◽

pp. 447-457 ◽

Cited By ~ 3

Author(s):

D. Hamm ◽

D.M. Witherspoon ◽

J.R. Buell ◽

C.L. Chen ◽

W. Jöchle

Keyword(s):

Dose Response ◽

Prostaglandin Analog ◽

Dose Response Study

Download Full-text

Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans

Diabetes ◽

10.2337/diabetes.37.10.1351 ◽

1988 ◽

Vol 37 (10) ◽

pp. 1351-1357 ◽

Cited By ~ 11

Author(s):

H. Tillil ◽

E. T. Shapiro ◽

A. H. Rubenstein ◽

J. A. Galloway ◽

K. S. Polonsky

Keyword(s):

Dose Response ◽

Insulin Clearance ◽

Hyperglycemic Clamp ◽

Normal Humans ◽

Dose Response Study

Download Full-text

Faculty Opinions recommendation of Hypobaric spinal anesthesia with ropivacaine plus sufentanil for traumatic femoral neck surgery in the elderly: a dose-response study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718001346.793476939 ◽

2013 ◽

Author(s):

Jan Jakobsson

Keyword(s):

Femoral Neck ◽

Spinal Anesthesia ◽

Dose Response ◽

The Elderly ◽

Neck Surgery ◽

Surgery In The Elderly ◽

Dose Response Study

Download Full-text

Faculty Opinions recommendation of Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727235926.793527815 ◽

2017 ◽

Author(s):

Juan Ferrando ◽

José M Mir-Bonafé

Keyword(s):

Hair Loss ◽

Dose Response ◽

Female Pattern Hair Loss ◽

Topical Minoxidil ◽

Dose Response Study

Download Full-text

Archiving of Food Samples from Restaurants and Caterers—Quantitative Profiling of Outbreaks of Foodborne Salmonellosis in Japan

Journal of Food Protection ◽

10.4315/0362-028x-67.9.2024 ◽

2004 ◽

Vol 67 (9) ◽

pp. 2024-2032 ◽

Cited By ~ 10

Author(s):

FUMIKO KASUGA ◽

MASAMITSU HIROTA ◽

MASAMICHI WADA ◽

TOSHIHIKO YUNOKAWA ◽

HAJIME TOYOFUKU ◽

...

Keyword(s):

Dose Response ◽

Storage System ◽

Epidemiological Data ◽

Food Samples ◽

Food Storage ◽

Disease Rate ◽

Data Sets ◽

Response Data ◽

Quantitative Profiling

The Ministry of Health, Labor and Welfare (former MHW) of Japan issued a Directive in 1997 advising restaurants and caterers to freeze portions of both raw food and cooked dishes for at least 2 weeks. This system has been useful for determining vehicle foods at outbreaks. Enumeration of bacteria in samples of stored food provide data about pathogen concentrations in the implicated food. Data on Salmonella concentrations in vehicle foods associated with salmonellosis outbreaks were collected in Japan between 1989 and 1998. The 39 outbreaks that occurred during this period were categorized by the settings where the outbreaks took place, and epidemiological data from each outbreak were summarized. Characteristics of outbreak groups were analyzed and compared. The effect of new food-storage system on determination of bacterial concentration was evaluated. Freezing and nonfreezing conditions prior to microbial examination were compared in the dose-response relationship. Data from outbreaks in which implicated foods had been kept frozen suggested apparent correlation between the Salmonella dose ingested and the disease rate. Combined with results of epidemiological investigation, quantitative data from the ingested pathogen could provide complete dose-response data sets.

Download Full-text