Serine protease inhibitor Kazal type 1 (SPINK 1 ) downregulates E-cadherin and induces EMT of hepatoma cells to promote hepatocellular carcinoma metastasis via the MEK/ERK signaling pathway

2017 ◽  
Vol 18 (6) ◽  
pp. 349-358 ◽  
Author(s):  
Hai Yan Ying ◽  
Chao Jie Gong ◽  
Yi Feng ◽  
Da Dao Jing ◽  
Lun Gen Lu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Signaling Pathway ◽  
Serine Protease Inhibitor ◽  
Hepatoma Cells ◽  
Erk Signaling ◽  
Carcinoma Metastasis ◽  
Spink 1

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

10.1038/76088 ◽  
2000 ◽  
Vol 25 (2) ◽  
pp. 213-216 ◽  
Author(s):  
Heiko Witt ◽  
Werner Luck ◽  
Hans Christian Hennies ◽  
Martin Claßen ◽  
Andreas Kage ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Protease Inhibitor ◽  
Serine Protease ◽  
Serine Protease Inhibitor ◽  
Gene Encoding

THE [−215G>A; IVS3+2T>C] MUTATION IN THE SERINE PROTEASE INHIBITOR KAZAL TYPE 1 (SPINK1) GENE IS FREQUENT IN JAPANESE PATIENTS WITH PANCREATITIS.

Pancreas ◽  
2004 ◽  
Vol 29 (4) ◽  
pp. 347-348
Author(s):  
K. Kume ◽  
A. Masamune ◽  
H. Mizutamari ◽  
K. Kaneko ◽  
K. Kikuta ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Serine Protease ◽  
Japanese Patients ◽  
Serine Protease Inhibitor

Chronic Hereditary Pancreatitis in a Girl With a Serine Protease Inhibitor Kazal Type I (SPINK-1) Gene Mutation and a Coxsackie Type B5 Infection

2009 ◽  
Vol 28 (2) ◽  
pp. 169-170 ◽  
Author(s):  
Michael Groeneweg ◽  
Jan W. Poley ◽  
Marlies Dansen ◽  
Jan G. Brinkman ◽  
Johanna C. Escher ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Serine Protease ◽  
Gene Mutation ◽  
Serine Protease Inhibitor ◽  
Type I ◽  
Hereditary Pancreatitis ◽  
Spink 1

Interleukin-6 increases expression of serine protease inhibitor Kazal type 1 through STAT3 in colorectal adenocarcinoma

2015 ◽  
Vol 55 (12) ◽  
pp. 2010-2023 ◽  
Author(s):  
Kati Räsänen ◽  
Elina Lehtinen ◽  
Kristiina Nokelainen ◽  
Teijo Kuopio ◽  
Laura Hautala ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Serine Protease ◽  
Interleukin 6 ◽  
Colorectal Adenocarcinoma ◽  
Serine Protease Inhibitor
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