Assessment of venous wall thickness with Doppler ultrasonography may be a diagnostic tool for Behçet’s disease

Abstract Objectives Diagnosing Behçet’s disease (BD) is a challenge, especially in countries with a low prevalence. Recently, venous wall thickness (VWT) in lower extremities has been shown to be increased in BD patients. In this study, we aimed to investigate the diagnostic performance of common femoral vein (CFV) thickness measurement in BD and whether it can be used as a diagnostic tool. Methods . Patients with BD (n = 152), ankylosing spondylitis (n = 27), systemic vasculitides (n = 23), venous insufficiency (n = 29), antiphospholipid syndrome (APS; n = 43), deep vein thrombosis due to non-inflammatory causes (n = 25) and healthy controls (n = 51) were included in the study. Bilateral CFV thickness was measured with ultrasonography by a radiologist blinded to cases. Results Bilateral CFV thickness was significantly increased in BD compared with all control groups (P < 0.001 for all). The area under the receiver operating characteristic curve for bilateral CFV thicknesses in all comparator groups was >0.95 for the cut-off value (0.5 mm). This cut-off value also performed well against all control groups with sensitivity rates >90%. The specificity rate was also >80% in all comparator groups except APS (positive predictive value: 79.2–76.5%, negative predictive value: 92–91.8% for right and left CFV, respectively). Conclusion Increased CFV thickness is a distinctive feature of BD and is rarely present in healthy and diseased controls, except APS. Our results suggest that CFV thickness measurement with ultrasonography, a non-invasive radiological modality, can be a diagnostic tool for BD with sensitivity and the specificity rates higher than 80% for the cut-off value ≥0.5 mm.

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AB0474 CAROTID CONTRAST ENHANCED ULTRASOUND IN CASES OF TAKAYASU ARTERITIS COMPLICATED WITH BEHCET’S DISEASE

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.3417 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1535.1-1535

Author(s):

W. Fan ◽

J. Zhu ◽

P. Yu ◽

L. Yu ◽

X. Wang ◽

...

Keyword(s):

Behçet’S Disease ◽

Clinical Data ◽

Wall Thickness ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Contrast Enhanced Ultrasound ◽

Artery Wall ◽

Behcet's Disease ◽

Contrast Enhanced ◽

Carotid Wall

Background:Carotid contrast enhanced ultrasound (CEUS) is used for diagnosis and activity determination of patients with Takayasu’s arteritis (TA). However, very little is known about the carotid CEUS features of TA complicated with Behcet’s disease (BD).Objectives:This study reports the carotid CEUS features in cases of TA complicated with BD (TBD).Methods:A total of 10 carotid CEUS examinations were performed on 4 patients of TBD. 10 TA patients complicated with no rheumatoid disease were included as control group. For each carotid artery lesion, the carotid CEUS features was graded as follows: Grade 0, artery wall shows no microbubbles, Grade 1, artery wall shows limited or moderate microbubbles, Grade 2, artery wall shows severe microbubbles.Results:2/10 patients in TBD group has oral ulcer during the CEUS examination, while all the other patients included in our study showed no clinical symptoms related to active TA or BD. The carotid wall thickness was greater of CEUS grade 2 than grade 1 in both group(TBD: 2.62±0.74mm vs 1.66±0.22mm,p=0.001; TA:1.84±0.31mm vs 1.53±0.5mm,p=0.136). The carotid wall thickness was significantly greater in TBD group than TA group, but there was no significant differences between the two groups in clinical data and CEUS grade (table 1).Table 1.Clinical data and carotid CEUS features of both groupsTBDTApAge (year)32.5±3.4430.5±9.20.487Male320.605ESR (mm/h)4(2, 10)7(3.5, 11)0.406CRP (mg/L)6.42(0.55, 15.38)0.58(0.44, 5.05)0.168Wall thickness (mm)2.10±0.701.67±0.440.030CEUS grade 29120.527Conclusion:This study first shows carotid CEUS features in cases of TA complicated with BD, which may help with the comprehensive treatments of the disease.Disclosure of Interests: :None declared

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