Current evidence supports use of lipid rescue therapy in local anaesthetic systemic toxicity

2017 ◽  
Vol 61 (4) ◽  
pp. 365-368 ◽  
Author(s):  
G. Weinberg
Keyword(s):  
Local Anaesthetic ◽  
Rescue Therapy ◽  
Systemic Toxicity ◽  
Current Evidence ◽  
Lipid Rescue

Guidelines and the adoption of ‘lipid rescue’ therapy for local anaesthetic toxicity

Anaesthesia ◽  
2009 ◽  
Vol 64 (2) ◽  
pp. 122-125 ◽  
Author(s):  
J. Picard ◽  
S. C. Ward ◽  
R. Zumpe ◽  
T. Meek ◽  
J. Barlow ◽  
...  
Keyword(s):  
Local Anaesthetic ◽  
Rescue Therapy ◽  
Lipid Rescue

Updates in our understanding of local anaesthetic systemic toxicity: a narrative review

Anaesthesia ◽  
2021 ◽  
Vol 76 (S1) ◽  
pp. 27-39
Author(s):  
A. J. R. Macfarlane ◽  
M. Gitman ◽  
K. J. Bornstein ◽  
K. El‐Boghdadly ◽  
G. Weinberg
Keyword(s):  
Local Anaesthetic ◽  
Systemic Toxicity ◽  
Narrative Review

The Effect of Anaesthetic Agents on Platelet Function

1991 ◽  
Vol 19 (4) ◽  
pp. 495-505 ◽  
Author(s):  
N. M. Gibbs
Keyword(s):  
Platelet Aggregation ◽  
Platelet Function ◽  
Local Anaesthetic ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Muscle Relaxants ◽  
Current Evidence ◽  
Inhibit Platelet Aggregation ◽  
Anaesthetic Agents ◽  
Thrombotic Complications

This paper reviews studies which have investigated the effect of anaesthetic agents on platelet function The results of these studies suggest that halothane is the only agent in current use which inhibits platelet function in concentrations used clinically. Nitrous oxide appears to cause only a modest inhibition, while enflurane and isoflurane appear to have minimal or negligible effects. There is no current evidence that intravenous induction agents opiates, or muscle relaxants affect platelet function. Reports indicate that local anaesthetic agents inhibit platelet aggregation, but only at concentrations far greater than peak plasma concentrations found during clinical use. Epidural anaesthesia may be associated with a reduction in platelet aggregation through a mechanism unrelated to direct local anaesthetic inhibition. The clinical significance of the effect of halothane on platelet function is not known. However, it is possible that halothane may affect bleeding or thrombotic complications in a similar manner to other ‘anti-platelet’ drugs.

Lipid “Rescue” Therapy

2018 ◽  
pp. 831-834
Author(s):  
Kathryn Benavides ◽  
Jonathan Babyak
Keyword(s):  
Rescue Therapy ◽  
Lipid Rescue
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