scholarly journals The Effects of Varenicline on Alcohol Seeking and Self-Administration in Baboons

2013 ◽  
Vol 38 (2) ◽  
pp. 376-383 ◽  
Author(s):  
Barbara J. Kaminski ◽  
Elise M. Weerts
Keyword(s):  
Self Administration ◽  
Alcohol Seeking

scholarly journals Stress vulnerability promotes an alcohol prone phenotype in a preclinical model of sustained depression

2018 ◽  
Author(s):  
Danai Riga ◽  
Leanne JM Schmitz ◽  
Yvar van Mourik ◽  
Witte JG Hoogendijk ◽  
Taco J De Vries ◽  
...  
Keyword(s):  
Social Defeat ◽  
Preclinical Model ◽  
Self Administration ◽  
Depression Vulnerability ◽  
Stress Vulnerability ◽  
The Social ◽  
Depression Proneness ◽  
Male Wistar Rats ◽  
Alcohol Seeking

AbstractMajor depression and alcohol-related disorders frequently co-occur. Depression severity weighs on the magnitude and persistence of comorbid alcohol use disorder (AUD), with severe implications for disease prognosis. Here, we investigated whether depression vulnerability drives propensity to AUD at the preclinical level. We used the social defeat-induced persistent stress (SDPS) model of chronic depression in combination with operant alcohol self-administration (SA). Male Wistar rats were subjected to social defeat (5 episodes) and prolonged social isolation (~12 weeks) and subsequently classified as SDPS-prone or SDPS-resilient based on their affective and cognitive performance. Using an operant alcohol SA paradigm, acquisition, motivation, extinction and cue-induced reinstatement of alcohol-seeking were examined in the two subpopulations. SDPS-prone animals showed increased alcohol SA, excessive motivation to acquire alcohol, persistent alcohol-seeking despite alcohol unavailability, extinction resistance and increased cue-induced relapse; the latter could be blocked by the α2 adrenoreceptor agonist guanfacine. In SDPS-resilient rats, prior exposure to social defeat increased alcohol SA without affecting any other measures of alcohol-seeking and -taking. Our data revealed that depression proneness confers vulnerability to alcohol, emulating patterns of alcohol dependence seen in human addicts, and that depression resilience to a large extent protects from the development of AUD-like phenotypes. Furthermore, our data suggest that stress exposure alone, independently of depressive symptoms, alters alcohol intake in the long-term.

scholarly journals The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats

2017 ◽  
Vol 42 (9) ◽  
pp. 1789-1799 ◽  
Author(s):  
Eric Augier ◽  
Russell S Dulman ◽  
Ruslan Damadzic ◽  
Andrew Pilling ◽  
J Paul Hamilton ◽  
...  
Keyword(s):  
Allosteric Modulator ◽  
Self Administration ◽  
Positive Allosteric Modulator ◽  
Alcohol Seeking

Effects of Ethanol Exposure on Subsequent Acquisition and Extinction of Ethanol Self-Administration and Expression of Alcohol-Seeking Behavior in Adult Alcohol-Preferring (P) Rats: II. Adult Exposure

2002 ◽  
Vol 26 (11) ◽  
pp. 1642-1652 ◽  
Author(s):  
Zachary A. Rodd-Henricks ◽  
Richard L. Bell ◽  
Kelly A. Kuc ◽  
James M. Murphy ◽  
William J. McBride ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Self Administration ◽  
Seeking Behavior ◽  
Adult Exposure ◽  
Alcohol Seeking

scholarly journals Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

2019 ◽  
Author(s):  
Koral Goltseker ◽  
Hen Handrus ◽  
Segev Barak
Keyword(s):  
Memory Retrieval ◽  
Lever Press ◽  
Water Flooding ◽  
Memory Reconsolidation ◽  
Place Conditioning ◽  
Self Administration ◽  
Conditioning Paradigm ◽  
Cocaine Seeking ◽  
Lever Pressing ◽  
Alcohol Seeking

AbstractRelapse to alcohol abuse is often caused by exposure to potent alcohol-associated cues. Therefore, disruption of the cue-alcohol memory can prevent relapse. It is believed that memories destabilize and become prone for updating upon their reactivation through retrieval, and then re-stabilize within 6 h during a “reconsolidation” process. We recently showed that relapse to cocaine seeking could be prevented by counterconditioning the cocaine-cues with aversive outcomes following cocaine-memory retrieval, in a place conditioning paradigm. However, to better model addiction-related behaviors, self-administration models are necessary. Here, we demonstrate that relapse to alcohol seeking can be prevented by aversive counterconditioning conducted during alcohol-memory reconsolidation, in conditioned place preference (CPP) and operant self-administration paradigms, in mice and rats, respectively. We found that the reinstatement of alcohol-CPP was abolished only when aversive counterconditioning with water-flooding was given shortly after alcohol-memory retrieval. Furthermore, rats trained to lever-press for alcohol showed decreased context-induced renewal of alcohol-seeking responding when the lever-pressing was counterconditioned with foot-shocks, shortly, but not 6 h, after memory retrieval. These results 0suggest that aversive counterconditioning can prevent relapse to alcohol seeking only when performed during alcohol-memory reconsolidation, presumably by updating, or replacing, the alcohol memory with aversive information. Also, we found that aversive counterconditioning preceded by alcohol-memory retrieval was characterized by upregulation of brain-derived neurotrophic factor (Bdnf) mRNA expression in the medial prefrontal cortex, suggesting that Bdnf plays a role in the memory updating process.

scholarly journals Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons

2012 ◽  
Vol 227 (1) ◽  
pp. 127-136 ◽  
Author(s):  
Barbara J. Kaminski ◽  
Michael L. Van Linn ◽  
James M. Cook ◽  
Wenyuan Yin ◽  
Elise M. Weerts
Keyword(s):  
Self Administration ◽  
Alcohol Seeking

Evidence for the role of dopamine D3receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in mice

2007 ◽  
Vol 12 (1) ◽  
pp. 35-50 ◽  
Author(s):  
Christian A. Heidbreder ◽  
Michela Andreoli ◽  
Cristina Marcon ◽  
Daniel M. Hutcheson ◽  
Eliot L. Gardner ◽  
...  
Keyword(s):  
Self Administration ◽  
Seeking Behavior ◽  
Alcohol Seeking

scholarly journals Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self‐administration paradigms

2021 ◽  
Author(s):  
Melissa A. Cyders ◽  
Martin H. Plawecki ◽  
Zachary T. Whitt ◽  
Ann E.K. Kosobud ◽  
David A. Kareken ◽  
...  
Keyword(s):  
Preclinical Models ◽  
Self Administration ◽  
Human Laboratory ◽  
Alcohol Seeking

scholarly journals The Novel Positive Allosteric Modulator of the GABAB Receptor, KK-92A, Suppresses Alcohol Self-Administration and Cue-Induced Reinstatement of Alcohol Seeking in Rats

2021 ◽  
Vol 9 ◽  
Author(s):  
Paola Maccioni ◽  
Katarzyna Kaczanowska ◽  
Harshani Lawrence ◽  
Sang Yun ◽  
Jessica Bratzu ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Drugs Of Abuse ◽  
Gabab Receptor ◽  
Fixed Ratio ◽  
Progressive Ratio ◽  
Spontaneous Locomotor Activity ◽  
Schedules Of Reinforcement ◽  
Self Administration ◽  
Motivated Behaviors ◽  
Alcohol Seeking

Positive allosteric modulators (PAMs) of the GABAB receptor (GABAB PAMs) are of interest in the addiction field due to their ability to suppress several behaviors motivated by drugs of abuse. KK-92A is a novel GABAB PAM found to attenuate intravenous self-administration of nicotine and reinstatement of nicotine seeking in rats. This present study was aimed at extending to alcohol the anti-addictive properties of KK-92A. To this end, Sardinian alcohol-preferring rats were trained to lever-respond for oral alcohol (15% v/v) or sucrose (0.7% w/v) under the fixed ratio (FR) 5 (FR5) schedule of reinforcement. Once lever-responding behavior had stabilized, rats were exposed to tests with acutely administered KK-92A under FR5 and progressive ratio schedules of reinforcement and cue-induced reinstatement of previously extinguished alcohol seeking. KK-92A effect on spontaneous locomotor activity was also evaluated. Treatment with 10 and 20 mg/kg KK-92A suppressed lever-responding for alcohol, amount of self-administered alcohol, and breakpoint for alcohol. Treatment with 20 mg/kg KK-92A reduced sucrose self-administration. Combination of per se ineffective doses of KK-92A (2.5 mg/kg) and the GABAB receptor agonist, baclofen (1 mg/kg), reduced alcohol self-administration. Treatment with 5, 10, and 20 mg/kg KK-92A suppressed reinstatement of alcohol seeking. Only treatment with 80 mg/kg KK-92A affected spontaneous locomotor activity. These results demonstrate the ability of KK-92A to inhibit alcohol-motivated behaviors in rodents and confirm that these effects are common to the entire class of GABAB PAMs. The remarkable efficacy of KK-92A is discussed in terms of its ago-allosteric properties.

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