scholarly journals Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self‐administration paradigms

2021 ◽  
Author(s):  
Melissa A. Cyders ◽  
Martin H. Plawecki ◽  
Zachary T. Whitt ◽  
Ann E.K. Kosobud ◽  
David A. Kareken ◽  
...  
Keyword(s):  
Preclinical Models ◽  
Self Administration ◽  
Human Laboratory ◽  
Alcohol Seeking

scholarly journals A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation

2018 ◽  
Author(s):  
Mehdi Farokhnia ◽  
Sara L. Deschaine ◽  
Armin Sadighi ◽  
Lisa A. Farinelli ◽  
Mary R. Lee ◽  
...  
Keyword(s):  
Laboratory Investigation ◽  
Lessons Learned ◽  
Insight Into ◽  
Human Laboratory ◽  
Alcohol Seeking

scholarly journals Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies.

2020 ◽  
Vol 28 (4) ◽  
pp. 417-425
Author(s):  
Carolina L. Haass-Koffler ◽  
Nazzareno Cannella ◽  
Roberto Ciccocioppo
Keyword(s):  
Alcohol Tolerance ◽  
Laboratory Studies ◽  
Preclinical Models ◽  
Human Laboratory

scholarly journals Stress vulnerability promotes an alcohol prone phenotype in a preclinical model of sustained depression

2018 ◽  
Author(s):  
Danai Riga ◽  
Leanne JM Schmitz ◽  
Yvar van Mourik ◽  
Witte JG Hoogendijk ◽  
Taco J De Vries ◽  
...  
Keyword(s):  
Social Defeat ◽  
Preclinical Model ◽  
Self Administration ◽  
Depression Vulnerability ◽  
Stress Vulnerability ◽  
The Social ◽  
Depression Proneness ◽  
Male Wistar Rats ◽  
Alcohol Seeking

AbstractMajor depression and alcohol-related disorders frequently co-occur. Depression severity weighs on the magnitude and persistence of comorbid alcohol use disorder (AUD), with severe implications for disease prognosis. Here, we investigated whether depression vulnerability drives propensity to AUD at the preclinical level. We used the social defeat-induced persistent stress (SDPS) model of chronic depression in combination with operant alcohol self-administration (SA). Male Wistar rats were subjected to social defeat (5 episodes) and prolonged social isolation (~12 weeks) and subsequently classified as SDPS-prone or SDPS-resilient based on their affective and cognitive performance. Using an operant alcohol SA paradigm, acquisition, motivation, extinction and cue-induced reinstatement of alcohol-seeking were examined in the two subpopulations. SDPS-prone animals showed increased alcohol SA, excessive motivation to acquire alcohol, persistent alcohol-seeking despite alcohol unavailability, extinction resistance and increased cue-induced relapse; the latter could be blocked by the α2 adrenoreceptor agonist guanfacine. In SDPS-resilient rats, prior exposure to social defeat increased alcohol SA without affecting any other measures of alcohol-seeking and -taking. Our data revealed that depression proneness confers vulnerability to alcohol, emulating patterns of alcohol dependence seen in human addicts, and that depression resilience to a large extent protects from the development of AUD-like phenotypes. Furthermore, our data suggest that stress exposure alone, independently of depressive symptoms, alters alcohol intake in the long-term.

scholarly journals The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats

2017 ◽  
Vol 42 (9) ◽  
pp. 1789-1799 ◽  
Author(s):  
Eric Augier ◽  
Russell S Dulman ◽  
Ruslan Damadzic ◽  
Andrew Pilling ◽  
J Paul Hamilton ◽  
...  
Keyword(s):  
Allosteric Modulator ◽  
Self Administration ◽  
Positive Allosteric Modulator ◽  
Alcohol Seeking

Effects of Ethanol Exposure on Subsequent Acquisition and Extinction of Ethanol Self-Administration and Expression of Alcohol-Seeking Behavior in Adult Alcohol-Preferring (P) Rats: II. Adult Exposure

2002 ◽  
Vol 26 (11) ◽  
pp. 1642-1652 ◽  
Author(s):  
Zachary A. Rodd-Henricks ◽  
Richard L. Bell ◽  
Kelly A. Kuc ◽  
James M. Murphy ◽  
William J. McBride ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Self Administration ◽  
Seeking Behavior ◽  
Adult Exposure ◽  
Alcohol Seeking

scholarly journals Establishing Preclinical Withdrawal Syndrome Symptomatology Following Heroin Self-Administration in Male and Female Rats

2020 ◽  
Author(s):  
Cassandra D. Gipson ◽  
Kelly E. Dunn ◽  
Amanda Bull ◽  
Hanaa Ulangkaya ◽  
Aronee Hossain
Keyword(s):  
Phase 1 ◽  
Opioid Withdrawal ◽  
Female Rats ◽  
Preclinical Models ◽  
Self Administration ◽  
Male And Female ◽  
Somatic Signs ◽  
Male And Female Rats ◽  
Opioid Administration ◽  
Abrupt Discontinuation

AbstractOpioid use disorder (OUD) is a significant health problem, and understanding mechanisms of various aspects of OUD including drug use and withdrawal is important. Preclinical models provide an ideal opportunity to evaluate mechanisms underlying opioid withdrawal. Current models are limited by their reliance upon forced opioid administration, focus on the acute (and not protracted) syndrome, and exclusion of females. In this study, male and female rats self-administered heroin (maintenance dose of 12.5 μg/kg/infusion) opioid withdrawal following abrupt discontinuation was measured. In Phase 1, acute withdrawal symptoms were rated in male and female rats at 0, 16, 48, and 72 hrs following the last self-administration session. Total somatic signs increased until 48 hrs (predominantly in females), and heroin intake positively correlated with total somatic signs at the 48 and 72 hr timepoints. Measures of hyperactivity and anxiety-like behavior increased by 16 and 48 hrs, respectively. In Phase 2, symptoms were assessed at baseline, acute, and protracted (168 and 312 hrs after self-administration) timepoints in a subset of male and female rats from Phase 1. The total number of somatic signs did not differ across timepoints, though females displayed significantly higher body temperature at all timepoints compared to males, indicating sex-specific protracted withdrawal symptomatology. These data provide a thorough characterization of rodent opioid withdrawal symptomatology following self-administration and abrupt discontinuation that serve as a foundation for future studies designed to mimic the human experience, and demonstrate the importance of characterizing acute and protracted withdrawal with sex-specificity in preclinical models of opioid self-administration.

scholarly journals Disruption of relapse to alcohol seeking by aversive counterconditioning following memory retrieval

2019 ◽  
Author(s):  
Koral Goltseker ◽  
Hen Handrus ◽  
Segev Barak
Keyword(s):  
Memory Retrieval ◽  
Lever Press ◽  
Water Flooding ◽  
Memory Reconsolidation ◽  
Place Conditioning ◽  
Self Administration ◽  
Conditioning Paradigm ◽  
Cocaine Seeking ◽  
Lever Pressing ◽  
Alcohol Seeking

AbstractRelapse to alcohol abuse is often caused by exposure to potent alcohol-associated cues. Therefore, disruption of the cue-alcohol memory can prevent relapse. It is believed that memories destabilize and become prone for updating upon their reactivation through retrieval, and then re-stabilize within 6 h during a “reconsolidation” process. We recently showed that relapse to cocaine seeking could be prevented by counterconditioning the cocaine-cues with aversive outcomes following cocaine-memory retrieval, in a place conditioning paradigm. However, to better model addiction-related behaviors, self-administration models are necessary. Here, we demonstrate that relapse to alcohol seeking can be prevented by aversive counterconditioning conducted during alcohol-memory reconsolidation, in conditioned place preference (CPP) and operant self-administration paradigms, in mice and rats, respectively. We found that the reinstatement of alcohol-CPP was abolished only when aversive counterconditioning with water-flooding was given shortly after alcohol-memory retrieval. Furthermore, rats trained to lever-press for alcohol showed decreased context-induced renewal of alcohol-seeking responding when the lever-pressing was counterconditioned with foot-shocks, shortly, but not 6 h, after memory retrieval. These results 0suggest that aversive counterconditioning can prevent relapse to alcohol seeking only when performed during alcohol-memory reconsolidation, presumably by updating, or replacing, the alcohol memory with aversive information. Also, we found that aversive counterconditioning preceded by alcohol-memory retrieval was characterized by upregulation of brain-derived neurotrophic factor (Bdnf) mRNA expression in the medial prefrontal cortex, suggesting that Bdnf plays a role in the memory updating process.

scholarly journals The Effects of Varenicline on Alcohol Seeking and Self-Administration in Baboons

2013 ◽  
Vol 38 (2) ◽  
pp. 376-383 ◽  
Author(s):  
Barbara J. Kaminski ◽  
Elise M. Weerts
Keyword(s):  
Self Administration ◽  
Alcohol Seeking
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