Hearing loss in association with topical imiquimod use for squamous cell carcinoma in situ (Bowen disease)

Cutaneous squamous cell carcinoma in situ of the eyelid and periorbital skin malignancies is common and its management is demanding. Surgical excision is considered the first-line treatment, but these techniques have limitations. Topical photodynamic therapy is currently approved for the treatment of squamous cell carcinoma in situ in other areas, but the reports of its use in this sensitive anatomic location area are scarce. Herein we report the case of a 61-year-old-man with extensive periocular Bowen disease that was treated successfully with photodynamic therapy. Photodynamic therapy may be an option as neoadjuvant or curative therapy in selected cases, especially in sensitive anatomic locations where surgery might lead to distortion of the structures or where techniques as micrographically controlled surgery are not available.

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PAGETOID SQUAMOUS CELL CARCINOMA IN SITU/PAGETOID BOWEN DISEASE: A RARE CASE

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2021.03.076 ◽

2021 ◽

Vol 132 (1) ◽

pp. e18

Author(s):

M Gormez ◽

E Cetin ◽

A Arici ◽

RD Koseoglu

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Carcinoma In Situ ◽

Rare Case ◽

Bowen Disease

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Extramammary Paget Disease of the Scrotum With Features of Bowen Disease

Archives of Pathology & Laboratory Medicine ◽

10.5858/2004-128-84-epdots ◽

2004 ◽

Vol 128 (1) ◽

pp. 84-86 ◽

Cited By ~ 1

Author(s):

Adam M. Quinn ◽

Anna Sienko ◽

Zane Basrawala ◽

Steve C. Campbell

Keyword(s):

Molecular Weight ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Carcinoma In Situ ◽

Low Molecular Weight ◽

Paget Disease ◽

Bowen Disease ◽

Erythematous Patch

Abstract The scrotum is an uncommon site for the presentation of extramammary Paget disease (EMPD). We describe a case of EMPD that was discovered in a patient who had been previously diagnosed and treated for squamous cell carcinoma in situ of the scrotum 3 years earlier. Pathologic examination of the current scrotectomy specimen revealed an erythematous patch with areas of pale induration. Microscopic examination revealed areas with the characteristic histology of Paget disease adjacent to areas characteristic of Bowen disease. Immunohistochemical findings demonstrated a strong expression of carcinoembryonic antigen, cytokeratin 7, and low-molecular-weight cytokeratins (CAM 5.2) in both of these areas, giving support to the overall diagnosis of EMPD. High-molecular-weight cytokeratins (34βE12) were uncharacteristically expressed in the cytoplasm of the Paget cells with equal or greater strength than in the surrounding keratinocytes, suggesting some degree of squamous differentiation. Very few publications have reported the coexistence of EMPD with squamous cell carcinoma in situ, occurring mostly in the vulva. To our knowledge, our case is the first report of scrotal EMPD with features of Bowen disease. Our findings support the theory that primary EMPD arises multifocally from multipotential epidermal cells.

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