Expression of programmed cell death ligand 1 (PD‐L1) at in situ and invasive extramammary Paget’s disease and literature review

2021 ◽  
Author(s):  
Junji Kato ◽  
Shintaro Sugita ◽  
Kohei Horimoto ◽  
Sayuri. Sato ◽  
Daisuke Yoneta ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Literature Review ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

scholarly journals Extramammary Paget's disease of the oral tissues—literature review and a rare case report

2016 ◽  
Vol 2016 (9) ◽  
pp. rjw152 ◽  
Author(s):  
Hana Kennedy ◽  
Jayanth Kunjur ◽  
Kavita Amarasinghe ◽  
Graham Smith
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Rare Case ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Rare Case Report ◽  
Extramammary Paget's Disease

Extramammary Paget's disease : a report of 69 cases with literature review

Skin Cancer ◽  
2013 ◽  
Vol 28 (1) ◽  
pp. 63-67
Author(s):  
Akinori YOKOMI ◽  
Atsushi TANEMURA ◽  
Aya TANAKA ◽  
Mamoru TANI ◽  
Ichiro KATAYAMA ◽  
...  
Keyword(s):  
Literature Review ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

scholarly journals Ectopic Extramammary Paget’s Disease: Case Report and Literature Review

2010 ◽  
Vol 90 (5) ◽  
pp. 502-505 ◽  
Author(s):  
Y Sawada ◽  
T Bito ◽  
R Kabashima ◽  
R Yoshiki ◽  
R Hino ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Disease Case ◽  
Extramammary Paget's Disease

scholarly journals Extramammary Paget’s Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments

2021 ◽  
Vol 28 (4) ◽  
pp. 2969-2986
Author(s):  
Shoichiro Ishizuki ◽  
Yoshiyuki Nakamura
Keyword(s):  
Paget’S Disease ◽  
Treatment Strategies ◽  
Distant Metastases ◽  
Disease Diagnosis ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
High Incidence ◽  
Recent Developments ◽  
Extramammary Paget's Disease

Extramammary Paget’s disease (EMPD) is a rare neoplasm that usually develops in apocrine gland-bearing areas, such as the vulva, scrotum, and penis. EMPD may present with a focal, multifocal, or an ectopic lesion. Clinically, EMPD lesions often exhibit infiltrative erythema, which is sometimes similar to other skin disorders such as eczema. While primary EMPD arises as intraepithelial neoplasm of the epidermis, EMPD-like lesions may occur from epidermotropic spread of malignant cells or direct extension from an underlying internal neoplasm, known as secondary EMPD. Because treatment strategies differ for primary EMPD and secondary EMPD, accurate diagnosis based on detailed histopathological evaluation is required. In the early stages, EMPD usually shows indolent growth, and most cases are diagnosed as carcinoma in situ. However, invasive lesions may result in metastases, and deep invasion is associated with high incidence of metastases. Conventional chemotherapies have been used for EMPD treatment in patients with distant metastases, but the efficacy is not satisfactory, and the prognosis for such patients remains poor. Recent studies have provided various insights into the molecular pathogenesis of the development and advancement of EMPD, which may lead to novel treatment approaches for metastatic EMPD. This review addresses the diagnosis, pathogenesis, and treatment of EMPD with focus on recent progress in understanding this disease.

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