P80: Efficacy of lymphocyte immunotherapy in the treatment of recurrent pregnancy loss: A systematic review and meta‐analysis

2021 ◽  
Vol 85 (S1) ◽  
pp. 100-101
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ka Ying Bonnie Ng ◽  
George Cherian ◽  
Alexandra J. Kermack ◽  
Sarah Bailey ◽  
Nick Macklon ◽  
...  

AbstractIt is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the context of BMI, smoking, alcohol and caffeine intake were included. The primary and secondary outcomes were odds of having RPL in the general population and odds of further miscarriage, respectively. Underweight and women with BMI > 25 are at higher odds of RPL in the general population (OR 1.2, 95% CI 1.12–1.28 and OR 1.21, 95% CI 1.06–1.38, respectively). In women with RPL, having BMI > 30 and BMI > 25 has increased odds of further miscarriages (OR 1.77, 95% CI 1.25–2.50 and OR 1.35, 95% CI 1.07–1.72, respectively). The quality of the evidence for our findings was low or very low. Being underweight and BMI > 25 contributes significantly to increased risk of RPL (general population). BMI > 25 or BMI > 30 increases the risk of further miscarriages (RPL population). Larger studies addressing the effects of alcohol, cigarette smoking and caffeine on the risk of RPL with optimisation of BMI in this cohort of women are now needed.


2020 ◽  
Vol 113 (3) ◽  
pp. 587-600.e1 ◽  
Author(s):  
Allan C. Dong ◽  
Jessica Morgan ◽  
Monica Kane ◽  
Alex Stagnaro-Green ◽  
Mary D. Stephenson

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Mohammad Masoud Eslami ◽  
Majid khalili ◽  
Mina Soufizomorrod ◽  
Saeid Abroun ◽  
Bahman Razi

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169891 ◽  
Author(s):  
Meixiang Zhang ◽  
Jiawei Xu ◽  
Xiao Bao ◽  
Wenbin Niu ◽  
Linlin Wang ◽  
...  

2020 ◽  
Vol 113 (4) ◽  
pp. 818-827.e3 ◽  
Author(s):  
Sarah J. Bunnewell ◽  
Emma R. Honess ◽  
Amar M. Karia ◽  
Stephen D. Keay ◽  
Bassel H. Al Wattar ◽  
...  

2018 ◽  
Vol 110 (6) ◽  
pp. 1089-1100 ◽  
Author(s):  
Chiara Achilli ◽  
Montserrat Duran-Retamal ◽  
Wael Saab ◽  
Paul Serhal ◽  
Srividya Seshadri

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