scholarly journals Comprehensive Bio-Imaging Using Myocardial Perfusion Reserve Index During Cardiac Magnetic Resonance Imaging and High-Sensitive Troponin T for the Prediction of Outcomes in Heart Transplant Recipients

2014 ◽  
Vol 14 (11) ◽  
pp. 2607-2616 ◽  
Author(s):  
N. P. Hofmann ◽  
C. Steuer ◽  
A. Voss ◽  
C. Erbel ◽  
S. Celik ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Troponin T ◽  
Myocardial Perfusion Reserve ◽  
Transplant Recipients ◽  
Resonance Imaging ◽  
Perfusion Reserve ◽  
Myocardial Perfusion Reserve Index ◽  
Bio Imaging ◽  
Heart Transplant Recipients ◽  
High Sensitive Troponin

Cardiac magnetic resonance imaging myocardial perfusion reserve index in heart transplant patients

2020 ◽  
Vol 62 (6) ◽  
pp. 493-501
Author(s):  
J.M. Jiménez Jaso ◽  
A. Ezponda ◽  
J. Muñiz Sáenz-Diez ◽  
M. Caballeros ◽  
G. Rábago ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Myocardial Perfusion Reserve ◽  
Resonance Imaging ◽  
Transplant Patients ◽  
Perfusion Reserve ◽  
Myocardial Perfusion Reserve Index ◽  
Imaging Myocardial Perfusion

scholarly journals A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging

1999 ◽  
Vol 33 (5) ◽  
pp. 1386-1394 ◽  
Author(s):  
J.H.S. Cullen ◽  
M.A. Horsfield ◽  
C.R. Reek ◽  
G.R. Cherryman ◽  
D.B. Barnett ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Myocardial Perfusion Reserve ◽  
Resonance Imaging ◽  
Perfusion Reserve ◽  
Myocardial Perfusion Reserve Index ◽  
Contrast Enhanced ◽  
First Pass

scholarly journals Molecular Mechanisms of Adenosine Stress T1 Mapping

2021 ◽  
Author(s):  
Soham A. Shah ◽  
Claire E. Reagan ◽  
Brent A. French ◽  
Frederick H. Epstein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Rate ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
T1 Mapping ◽  
Myocardial Perfusion Reserve ◽  
Adenosine Stress ◽  
Resonance Imaging ◽  
Perfusion Reserve

Background: Adenosine stress T1 mapping is an emerging magnetic resonance imaging method to investigate coronary vascular function and myocardial ischemia without application of a contrast agent. Using gene-modified mice and 2 vasodilators, we elucidated and compared the mechanisms of adenosine myocardial perfusion imaging and adenosine T1 mapping. Methods: Wild-type (WT), A 2A AR −/− (adenosine A 2A receptor knockout), A 2B AR −/− (adenosine A 2B receptor knockout), A 3 AR −/− (adenosine A 3 receptor knockout), and eNOS −/− (endothelial nitric oxide synthase knockout) mice underwent rest and stress perfusion magnetic resonance imaging (n=8) and T1 mapping (n=10) using either adenosine, regadenoson (a selective A 2A AR agonist), or saline. Myocardial blood flow and T1 were computed from perfusion imaging and T1 mapping, respectively, at rest and stress to assess myocardial perfusion reserve and T1 reactivity (ΔT1). Changes in heart rate for each stress agent were also calculated. Two-way ANOVA was used to detect differences in each parameter between the different groups of mice. Results: Myocardial perfusion reserve was significantly reduced only in A 2A AR −/− compared to WT mice using adenosine (1.06±0.16 versus 2.03±0.52, P <0.05) and regadenoson (0.98±026 versus 2.13±0.75, P <0.05). In contrast, adenosine ΔT1 was reduced compared with WT mice (3.88±1.58) in both A 2A AR −/− (1.63±1.32, P <0.05) and A 2B AR −/− (1.55±1.35, P <0.05). Furthermore, adenosine ΔT1 was halved in eNOS −/− (1.76±1.46, P <0.05) versus WT mice. Regadenoson ΔT1 was approximately half of adenosine ΔT1 in WT mice (1.97±1.50, P <0.05), and additionally, it was significantly reduced in eNOS −/− mice (−0.22±1.46, P <0.05). Lastly, changes in heart rate was 2× greater using regadenoson versus adenosine in all groups except A 2A AR −/− , where heart rate remained constant. Conclusions: The major findings are that (1) although adenosine myocardial perfusion reserve is mediated through the A 2A receptor, adenosine ΔT1 is mediated through the A 2A and A 2B receptors, (2) adenosine myocardial perfusion reserve is endothelial independent while adenosine ΔT1 is partially endothelial dependent, and (3) ΔT1 mediated through the A 2A receptor is endothelial dependent while ΔT1 mediated through the A 2B receptor is endothelial independent.

scholarly journals Allograft morphology and function in heart transplant recipients surviving more than 15 years by magnetic resonance imaging and dual-source computed tomography

2011 ◽  
Vol 40 (1) ◽  
pp. e62-e66 ◽  
Author(s):  
Stefano Mastrobuoni ◽  
Angelo Maria Dell’Aquila ◽  
Maria Arraiza ◽  
Gorka Bastarrika ◽  
Pedro Maria Azcarate ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Heart Transplant ◽  
Transplant Recipients ◽  
Resonance Imaging ◽  
Dual Source ◽  
Heart Transplant Recipients ◽  
And Function ◽  
Dual Source Computed Tomography

Safety and hemodynamic response of regadenoson stress cardiovascular magnetic resonance imaging in heart transplant recipients

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J Muniz Saenz Diez ◽  
M Luque Gonzalez ◽  
A Martinez Leon ◽  
J Ibero Valencia ◽  
E Iglesias Colino ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiovascular Magnetic Resonance ◽  
Heart Transplant ◽  
Cardiovascular Magnetic Resonance Imaging ◽  
Hemodynamic Response ◽  
Transplant Recipients ◽  
Resonance Imaging ◽  
Heart Transplant Recipients ◽  
Stress Cmr ◽  
Stress Cardiovascular Magnetic Resonance

Abstract Background The non-invasive detection of coronary allograft vasculopathy remains a challenge, and there is no consensus about which technique should be used. The hypersensitivity to vasodilator drugs (such as adenosine) of heart transplant recipients may have limited the use of stress cardiovascular magnetic resonance imaging (stress-CMR) in this group of patients. Regadenoson is a more specific agonist of adenosine receptors. There is still little data on its safety profile and the hemodynamic response it causes in these patients. Purpose We aimed to observe safety and hemodynamic response to regadenoson in heart transplant recipients. Methods We studied 505 consecutive patients (22 transplanted and 483 non-transplanted) who underwent stress-CMR between 06/06/2017 and 10/10/2019. We compared the hemodynamic response (blood pressure and heart rate) and the adverse effects and symptoms caused by regadenoson in both groups. Student t test and χ2 were used to compare the continuous and the qualitative variables between both groups, respectively. Results In transplant patients there were no events requiring finalization of the test (e.g. atrioventricular block, symptomatic arterial hypotension or poor tolerance to the symptomatic response to regadenoson). There were no differences in the incidence of symptoms after drug administration in transplanted versus non-transplanted patients (50% vs. 50.4%, p=0.97), and all of those symptoms were transient and well tolerated. Transplant recipients presented an attenuated hemodynamic response compared to non-transplanted patients (Table 1). Conclusions Stress-CMR with regadenoson is a safe and well tolerated technique in heart transplant recipients. In this group of patients, the hemodynamic response is blunted compared to non-transplanted patients. This lower response has been previously described in obese and diabetic patients, and it does not appear to affect the performance of the test. Further studies should confirm these findings. Funding Acknowledgement Type of funding source: None

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