Interleukin‐7 receptor blockade by an anti‐ CD 127 monoclonal antibody in nonhuman primate kidney transplantation

2019 ◽  
Vol 20 (1) ◽  
pp. 101-111 ◽  
Author(s):  
Hoa Le Mai ◽  
Thi Van Ha Nguyen ◽  
Julien Branchereau ◽  
Nicolas Poirier ◽  
Karine Renaudin ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplantation ◽  
Nonhuman Primate ◽  
Receptor Blockade ◽  
Interleukin 7

A Novel Fully Human Anti-CD40 Monoclonal Antibody, 4D11, for Kidney Transplantation in Cynomolgus Monkeys

2007 ◽  
Vol 84 (8) ◽  
pp. 1020-1028 ◽  
Author(s):  
Atsushi Imai ◽  
Tomomi Suzuki ◽  
Atsushi Sugitani ◽  
Tomoo Itoh ◽  
Shinya Ueki ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplantation ◽  
Cynomolgus Monkeys

C5a receptor blockade as a new therapeutic concept in kidney transplantation

2007 ◽  
Vol 44 (16) ◽  
pp. 3914-3915
Author(s):  
Alfor G. Lewis ◽  
Gabriele Köhl ◽  
Qing Ma ◽  
Prasad Devarajan ◽  
Jörg Köhl
Keyword(s):  
Kidney Transplantation ◽  
Receptor Blockade ◽  
C5a Receptor ◽  
Therapeutic Concept

scholarly journals Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation

2020 ◽  
Vol 20 (6) ◽  
pp. 1513-1526 ◽  
Author(s):  
Juan S. Danobeitia ◽  
Tiffany J. Zens ◽  
Peter J. Chlebeck ◽  
Laura J. Zitur ◽  
Jose A. Reyes ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Brain Death ◽  
Nonhuman Primate ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Nonhuman Primate Model ◽  
Primate Model

Selective Targeting of Activated LFA-1 Using a Novel Antibody, AL-579, in Nonhuman Primate Kidney Transplantation.

2014 ◽  
Vol 98 ◽  
pp. 26
Author(s):  
D. Lo ◽  
D. Anderson ◽  
M. Song ◽  
F. Leopardi ◽  
E. Strobert ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Nonhuman Primate ◽  
Selective Targeting

scholarly journals BLOCKING COMPLEMENT C3 IN A SENSITIZED NONHUMAN PRIMATE MODEL OF KIDNEY TRANSPLANTATION

2020 ◽  
Vol 104 (S3) ◽  
pp. S121-S121
Author(s):  
Robin Schmitz ◽  
Paul M. Schroder ◽  
Zachary W. Fitch ◽  
Ashley Y. Choi ◽  
Miriam Manook ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Nonhuman Primate ◽  
Complement C3 ◽  
Nonhuman Primate Model ◽  
Primate Model

scholarly journals Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 ◽  
Vol 178 (1) ◽  
pp. 257-264 ◽  
Author(s):  
K H Grabstein ◽  
T J Waldschmidt ◽  
F D Finkelman ◽  
B W Hess ◽  
A R Alpert ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
B Cells ◽  
B Cell ◽  
Culture Methods ◽  
Cell Stage ◽  
Interleukin 7 ◽  
Slow Turnover

The effects of interleukin 7 (IL-7) on the growth and differentiation of murine B cell progenitors has been well characterized using in vitro culture methods. We have investigated the role of IL-7 in vivo using a monoclonal antibody that neutralizes IL-7. We find that treatment of mice with this antibody completely inhibits the development of B cell progenitors from the pro-B cell stage forward. We also provide evidence that all peripheral B cells, including those of the B-1 and conventional lineages, are derived from IL-7-dependent precursors. The results are consistent with the rapid turnover of B cell progenitors in the marrow, but a slow turnover of mature B cells in the periphery. In addition to effects on B cell development, anti-IL-7 treatment substantially reduced thymus cellularity, affecting all major thymic subpopulations.

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