The natural killer cell activating receptor, NKG2D, is critical to antibody‐dependent chronic rejection in heart transplantation

2021 ◽  
Author(s):  
Christine M. Lin ◽  
Ronald G. Gill ◽  
Borna Mehrad
Keyword(s):  
Natural Killer Cell ◽  
Heart Transplantation ◽  
Natural Killer ◽  
Chronic Rejection ◽  
Killer Cell ◽  
Activating Receptor

scholarly journals Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30

2014 ◽  
Vol 74 (13) ◽  
pp. 3429-3440 ◽  
Author(s):  
Eva Schlecker ◽  
Nathalie Fiegler ◽  
Annette Arnold ◽  
Peter Altevogt ◽  
Stefan Rose-John ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Tumor Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Shedding ◽  
Activating Receptor

Abstract 875: Genetic variation in the natural killer cell activating receptor NKG2D and its ligands in relation to glioma risk and outcome

2011 ◽  
Author(s):  
James E. Browning ◽  
Reid C. Thompson ◽  
L. Burton Nabors ◽  
Jeffrey J. Olson ◽  
Melissa H. Madden ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Glioma Risk ◽  
Activating Receptor

scholarly journals Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112

2010 ◽  
Vol 91 (8) ◽  
pp. 2034-2039 ◽  
Author(s):  
Virginie Prod'homme ◽  
Daniel M. Sugrue ◽  
Richard J. Stanton ◽  
Akio Nomoto ◽  
James Davies ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Cell Surface ◽  
Natural Killer ◽  
Human Cytomegalovirus ◽  
Killer Cell ◽  
Surface Expression ◽  
Productive Infection ◽  
Cell Surface Expression ◽  
Poliovirus Receptor ◽  
Activating Receptor

Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like molecule 5; poliovirus receptor), a ligand for the activating receptor DNAM-1 (CD226). However, DNAM-1 is also recognized to bind a second ligand, CD112 (nectin-2). We now show that HCMV targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 from the cell surface during productive infection. Significantly, cell surface expression of both CD112 and CD155 was restored when UL141 was deleted from the HCMV genome. While gpUL141 alone is sufficient to mediate retention of CD155 in the endoplasmic reticulum, UL141 requires assistance from additional HCMV-encoded functions to suppress expression of CD112.

scholarly journals Complement factor P is a ligand for the natural killer cell–activating receptor NKp46

2017 ◽  
Vol 2 (10) ◽  
pp. eaam9628 ◽  
Author(s):  
Emilie Narni-Mancinelli ◽  
Laurent Gauthier ◽  
Myriam Baratin ◽  
Sophie Guia ◽  
Aurore Fenis ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Complement Factor ◽  
Activating Receptor

scholarly journals Effects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts

2015 ◽  
Vol 4 (1) ◽  
pp. 15-17
Author(s):  
Régis T. Costello ◽  
Amélie Leclercq ◽  
Thérèse Le Treut ◽  
Carole Sanchez ◽  
Delphine Mercier ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Receptor Expression ◽  
Refractory Anemia ◽  
Activating Receptor
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