scholarly journals Skin tests in urticaria/angioedema and flushing to Pfizer‐BioNTech SARS‐CoV‐2 vaccine: Limits of intradermal testing

Allergy ◽  
2021 ◽  
Author(s):  
Leonardo Bianchi ◽  
Filippo Biondi ◽  
Katharina Hansel ◽  
Nicola Murgia ◽  
Marta Tramontana ◽  
...  
Keyword(s):  
Skin Tests ◽  
Intradermal Testing

Skin testing in allergy

2019 ◽  
Vol 40 (6) ◽  
pp. 366-368
Author(s):  
Gayatri Patel ◽  
Carol Saltoun
Keyword(s):  
Skin Test ◽  
Immunoglobulin E ◽  
Clinical Symptoms ◽  
Skin Testing ◽  
Smooth Muscle Contraction ◽  
Skin Tests ◽  
Test Reaction ◽  
Positive Skin ◽  
Intradermal Testing ◽  
Clinical Sensitivity

Skin tests are used in addition to a directed history and physical examination to exclude or confirm immunoglobulin E (IgE) mediated diseases, such as allergic rhinitis, asthma, and anaphylaxis, to aeroallergens, foods, insect venoms, and certain drugs. There are two types of skin testing used in clinical practice: percutaneous testing (prick or puncture) and intracutaneous testing (intradermal). Prick testing involves introducing a needle into the upper layers of the skin through a drop of allergen extract that has been placed on the skin and gently lifting the epidermis up. Various devices are available for prick testing. Intracutaneous (intradermal) testing involves injecting a small amount of allergen into the dermis. The release of preformed histamine from mast cells causes increased vascular permeability via smooth-muscle contraction and development of a wheal; inflammatory mediators initiate a neural reflex, which causes vasodilatation, which leads to erythema (the flare). Prick testing methods are the initial technique for detecting the presence of IgE. These may correlate better with clinical sensitivity and are more specific but less sensitive than intradermal testing. Sites of skin testing include the back and the volar aspect of the arm. By skin testing on the arm, the patient can witness the emergence and often sense the pruritus of the skin test reaction. Because more patients are sensitized (have IgE antibodies and positive skin test reactions) than have corresponding symptoms, the diagnosis of allergy can be made only by correlating skin testing results with the presence of clinical symptoms.

scholarly journals Intradermal Drug Testing following Anaphylactoid Reactions during Anaesthesia

1981 ◽  
Vol 9 (4) ◽  
pp. 381-386 ◽  
Author(s):  
David Sage
Keyword(s):  
Drug Testing ◽  
False Negative ◽  
Skin Tests ◽  
Positive Information ◽  
Positive Skin ◽  
Intradermal Testing ◽  
Negative Results ◽  
False Negative Results ◽  
Intravenous Anaesthetic ◽  
Anaphylactoid Reactions

Intradermal testing of intravenous anaesthetic drugs was performed on 34 patients following acute anaphylactoid reactions during anaesthesia. Twenty-three patients had positive skin tests and 18 of these were positive for a single drug. Muscle relaxants were the drugs implicated most commonly. Intradermal testing is safe and provides useful and often specific positive information, but false-negative results probably occur.

scholarly journals Skin tests in adverse reactions to Pfizer-BioNTech SARS-CoV-2 vaccine: limits of intradermal testing

2021 ◽  
Author(s):  
Leonardo Bianchi ◽  
Filippo Biondi ◽  
Katharina Hansel ◽  
Nicola Murgia ◽  
Marta Tramontana ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Skin Tests ◽  
Intradermal Testing

scholarly journals Modified Oral Metronidazole Desensitization Protocol

2014 ◽  
Vol 5 (2) ◽  
pp. ar.2014.5.0080 ◽  
Author(s):  
Samantha R. Gendelman ◽  
Lily C. Pien ◽  
Ravi C. Gutta ◽  
Susan R. Abouhassan
Keyword(s):  
Nasal Congestion ◽  
Skin Tests ◽  
Positive Skin ◽  
Intradermal Testing ◽  
History Of ◽  
Desensitization Protocol ◽  
Ige Mediated ◽  
Systemic Symptoms ◽  
Oral Metronidazole ◽  
Oral Desensitization

The Center for Disease Control guidelines recommend desensitization to metronidazole in patients with trichomoniasis and hypersensitivity to metronidazole. There is only one published oral metronidazole desensitization protocol. The purpose of this study was to design a new, more gradual oral desensitization protocol to decrease systemic reactions that may occur when using the previously published protocol. We present two patients with presumed IgE-mediated allergy to metronidazole who underwent oral desensitization using our modified protocol. Case 1 was a 65-year-old woman with trichomoniasis who presented for metronidazole desensitization with a history of intraoperative anaphylaxis and positive skin tests to metronidazole. The patient tolerated six doses of the modified desensitization but developed systemic symptoms of nasal congestion and diffuse pruritus after the 25- and 100-mg doses. Both reactions were treated with intravenous (i.v.) antihistamines. Because of gastrointestinal irritation, the desensitization was completed at a dose of 250 mg orally every 6 hours. Case 2 was a 42-year-old woman with trichomoniasis and a history of hives immediately after administration of i.v. metronidazole who presented for desensitization. The patient had negative skin-prick and intradermal testing to metronidazole. She developed lip tingling and pruritus on her arms 15 minutes after the 10-mg dose. Fexofenadine at 180 mg was given orally and symptoms resolved. She tolerated the rest of the protocol without reaction and received a total dose of 2 g of metronidazole. Our oral metronidazole desensitization for presumed IgE-mediated reactions offers a second option for physicians wishing to use a more gradual escalation in dose.

Ability of caregivers to read delayed hypersensitivity skin tests in children exposed to and infected by HIV*1

2000 ◽  
Vol 14 (2) ◽  
pp. 50-55
Author(s):  
FORTHEPEDIATRICPULMONARYANDCA ◽  
H COHEN ◽  
X CHEN ◽  
S SUNKLE ◽  
L DAVIS ◽  
...  
Keyword(s):  
Delayed Hypersensitivity ◽  
Skin Tests ◽  
Hypersensitivity Skin ◽  
Hiv 1

7 Cases of Drug Eruptions, in which Generalized Rashes were Induced by Intradermal Testing.

1991 ◽  
Vol 53 (4) ◽  
pp. 705-712
Author(s):  
Sumi SAITO ◽  
Zenro IKEZAWA ◽  
Junko OSAWA ◽  
Shizuo NAITO ◽  
Michiko AIHARA ◽  
...  
Keyword(s):  
Intradermal Testing ◽  
Drug Eruptions

Studies on Su-DP skin tests. Histopathological and electron microscopic studies.

1988 ◽  
Vol 50 (4) ◽  
pp. 739-742
Author(s):  
Tomoko MIZUTANI ◽  
Yasuo NAKAMURA ◽  
Masayuki SHIMIZU
Keyword(s):  
Skin Tests ◽  
Electron Microscopic ◽  
Microscopic Studies
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