Thrombin cleaves IL‐33 and modulates IL‐33‐activated allergic lung inflammation

Allergy ◽  
2022 ◽  
Author(s):  
Yuying Huang ◽  
Xuezhen Li ◽  
Lin Zhu ◽  
Chunrong Huang ◽  
Wen Chen ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Allergic Lung Inflammation

scholarly journals Endogenous Attenuation of Allergic Lung Inflammation by Syndecan-1

2005 ◽  
Vol 174 (9) ◽  
pp. 5758-5765 ◽  
Author(s):  
Jie Xu ◽  
Pyong Woo Park ◽  
Farrah Kheradmand ◽  
David B. Corry
Keyword(s):  
Lung Inflammation ◽  
Allergic Lung Inflammation

Enhanced Infiltration of Central Memory T Cells to the Lung Tissue during Allergic Lung Inflammation

2021 ◽  
pp. 1-15
Author(s):  
Mashael Alabed ◽  
Asma Sultana Shaik ◽  
Narjes Saheb Sharif-Askari ◽  
Fatemeh Saheb Sharif-Askari ◽  
Shirin Hafezi ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Lung Tissue ◽  
Lung Inflammation ◽  
Inflammatory Responses ◽  
Memory T Cells ◽  
Central Memory ◽  
Effector Memory ◽  
Differential Distribution ◽  
Allergic Lung Inflammation

Memory T cells play a central role in regulating inflammatory responses during asthma. However, tissue distribution of effector memory (T<sub>EM</sub>) and central memory (T<sub>CM</sub>) T-cell subtypes, their differentiation, and their contribution to the persistence of lung tissue inflammation during asthma are not well understood. Interestingly, an increase in survival and persistence of memory T cells was reported in asthmatic lungs, which may suggest a shift toward the more persistent T<sub>CM</sub> phenotype. In this report, we investigated the differential distribution of memory T-cell subtypes during allergic lung inflammation and the mechanism regulating that. Using an OVA-sensitized asthma mouse model, we observed a significant increase in the frequency of T<sub>CM</sub> cells in inflamed lungs compared to healthy controls. Interestingly, adoptive transfer techniques confirmed substantial infiltration of T<sub>CM</sub> cells to lung tissues during allergic airway inflammation. Expression levels of T<sub>CM</sub> homing receptors, CD34 and GlyCAM-1, were also significantly upregulated in the lung tissues of OVA-sensitized mice, which may facilitate the increased T<sub>CM</sub> infiltration into inflamed lungs. Moreover, a substantial increase in the relative expression of T<sub>CM</sub> profile-associated genes (EOMES, BCL-6, ID3, TCF-7, BCL-2, BIM, and BMI-1) was noted for T<sub>EM</sub> cells during lung inflammation, suggesting a shift for T<sub>EM</sub> into the T<sub>CM</sub> state. To our knowledge, this is the first study to report an increased infiltration of T<sub>CM</sub> cells into inflamed lung tissues and to suggest differentiation of T<sub>EM</sub> to T<sub>CM</sub> cells in these tissues. Therapeutic interference at T<sub>CM</sub> infiltration or differentiations could constitute an alternative treatment approach for lung inflammation.

scholarly journals Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation

2009 ◽  
Vol 42 (4) ◽  
pp. 339-345 ◽  
Author(s):  
J.L.Q. Durigan ◽  
S.M. Peviani ◽  
T.L. Russo ◽  
A.C.D. Silva ◽  
R.P. Vieira ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Lung Inflammation ◽  
Allergic Lung Inflammation

The Effects of Microbial Materials Adhered to Asian Sand Dust on Allergic Lung Inflammation

2008 ◽  
Vol 55 (3) ◽  
pp. 348-357 ◽  
Author(s):  
T. Ichinose ◽  
S. Yoshida ◽  
K. Hiyoshi ◽  
K. Sadakane ◽  
H. Takano ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Allergic Lung Inflammation ◽  
Asian Sand Dust ◽  
Sand Dust

Melatonin modulates allergic lung inflammation

2001 ◽  
Vol 31 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Eivor Martins ◽  
Ana Paula Ligeiro de Oliveira ◽  
Ana Maria Fialho de Araujo ◽  
Wothan Tavares de Lima ◽  
José Cipolla-Neto ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Allergic Lung Inflammation

scholarly journals Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide

2020 ◽  
Vol 48 (2) ◽  
pp. 030006052090366
Author(s):  
Chang Doo Lee ◽  
Won Seok Choi ◽  
Yong Geon Choi ◽  
Hyun Sik Kang ◽  
Wang Tae Lee ◽  
...  
Keyword(s):  
Murine Model ◽  
Lung Inflammation ◽  
Allergic Lung Inflammation
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